DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sas and CCN5

DIOPT Version :9

Sequence 1:	NP_001262337.1	Gene:	sas / 40861	FlyBaseID:	FBgn0002306	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001310299.1	Gene:	CCN5 / 8839	HGNCID:	12770	Length:	250	Species:	Homo sapiens

Alignment Length:	335	Identity:	69/335 - (20%)
Similarity:	97/335 - (28%)	Gaps:	137/335 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   654 KFRERLEIGCEQICHCAEGGVMDCRPRCPERNHTRLDKCVYVKDPKDVCCQLELCDVTLDDHEQQ 718
            |.|.:|   |...|.|...     .||||......||.|        .||:  :|
Human    20 KVRTQL---CPTPCTCPWP-----PPRCPLGVPLVLDGC--------GCCR--VC---------- 56

  Fly   719 PTPLQSNNNEDPEEIDPFRFQEQARDAGGAKPTCTFKGAEYDVGQQFRDGCDQLCICN-EQGIHC 782
                                   ||..|                    :.||||.:|: .||:.|
Human    57 -----------------------ARRLG--------------------EPCDQLHVCDASQGLVC 78

  Fly   783 AKLECPSNFGLDVQDPHCIRWEPVPADFKPSPPNCCPESMRCVDNGTCSYQGVQIENWSPVPANL 847
            .....|...|     ..|:..|               :...|..||....:|   |.:.|
Human    79 QPGAGPGGRG-----ALCLLAE---------------DDSSCEVNGRLYREG---ETFQP----- 115

  Fly   848 TGCDQHCYCENGRVECRAACPPVPALPPADLPCHPALARLLPIPDDECCKHWMCA---------- 902
             .|...|.||:|...|...|.....||..|.| ||....:|    .:||..|:|.
Human   116 -HCSIRCRCEDGGFTCVPLCSEDVRLPSWDCP-HPRRVEVL----GKCCPEWVCGQGGGLGTQPL 174

  Fly   903 -PQIPKIGGAGQDEETEATSTHSSIPANETTT------TTATANKSTSIPSKVPQIKKDEEKR-- 958
             .|.|:..|.       .:|....:|..|.:|      ||.....:|.:.::....:.:.::|
Human   175 PAQGPQFSGL-------VSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLC 232

  Fly   959 -----PPASG 963
                 ||:.|
Human   233 LSRPCPPSRG 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sas	NP_001262337.1	VWC	752..824	CDD:214564	12/72 (17%)
		fn3	1413..1479	CDD:278470
		FN3	1516..1605	CDD:238020
CCN5	NP_001310299.1	IGFBP	<44..78	CDD:306685	16/96 (17%)
CCN5	NP_001310299.1	VWC	100..160	CDD:327433	22/73 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11348
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100