DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sas and ccn4b

DIOPT Version :9

Sequence 1:	NP_001262337.1	Gene:	sas / 40861	FlyBaseID:	FBgn0002306	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_001107100.1	Gene:	ccn4b / 792714	ZFINID:	ZDB-GENE-080220-16	Length:	356	Species:	Danio rerio

Alignment Length:	381	Identity:	72/381 - (18%)
Similarity:	116/381 - (30%)	Gaps:	148/381 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 RDCDERCTCNRGDWMCEPRCRGLSYPRGSQRSMANPNCLEKMVEEDECCRVMECSEPQLEPTVVA 613
            |.|...|.|.:...:|                   |:.:..:::..:||:.  |::.
Zfish    39 RYCKWPCKCPKSALVC-------------------PHGVSLLMDGCDCCKA--CAKQ-------- 74

  Fly   614 TEGAAPSTNGTGESAVTLPTTD-------DEATPKPR-----------TDCHYNSGVYKFRERLE 660
                      .||:.......|       |.:..|||           |.|.||..:|:..:..:
Zfish    75 ----------AGETCNERDICDYHKGLYCDYSADKPRYEKGVCAYVMGTGCEYNGVIYRNGQSFQ 129

  Fly   661 IGCEQICHCAEGGVMDCRPRCPERNHTRLDKCVYVKDPKDV-----CCQLELCDVTLDDHEQQPT 720
            ..|:..|.|..|.: .|.|.|.:    .|...|:.:.||.|     ||:..:|       |:...
Zfish   130 PNCKYRCLCVNGAI-GCVPLCTD----SLPPRVWCQSPKRVKIPGQCCEKWIC-------EESRK 182

  Fly   721 PLQSNNNEDPEEID--------------PFR----------------------FQEQARDAGGAK 749
            |.::|....|.|:.              |:.                      .::::|
Zfish   183 PRKTNPRHAPAEVSANDIWHNNCIAQTTPWSPCSKTCGRGISLRISNENAGCVMEKESR------ 241

  Fly   750 PTCTFKGAEYDVGQQFRDGCDQLCICNEQGIHCAKLECPSNFGLDVQDPHCIRWEPVPADFKPSP 814
             .|..:..|.|:.:.||.|...|.|..|...        .||.:.    .|:       ..||..
Zfish   242 -LCNLRPCEVDITKHFRPGKKCLNIYREPEF--------QNFTIS----GCV-------SKKPYW 286

  Fly   815 PNCCPESMRCVDNGTC-SYQG--VQIENWSPVPANLTG---CDQHCYCENGRVECR 864
            |..|..   |.|...| .|:.  :::|...|..|.||.   ....|:|   .:.||
Zfish   287 PKYCGV---CTDERCCIPYKSKTIEVEFECPDGALLTWKYMWINACFC---NLSCR 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sas	NP_001262337.1	VWC	752..824	CDD:214564	16/71 (23%)
		fn3	1413..1479	CDD:278470
		FN3	1516..1605	CDD:238020
ccn4b	NP_001107100.1	IGFBP	41..93	CDD:278641	11/90 (12%)
		VWC	115..174	CDD:214564	18/63 (29%)
		TSP1	208..249	CDD:214559	3/47 (6%)
		GHB_like	272..335	CDD:304424	18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11348
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100