DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sas and Ccn2

DIOPT Version :9

Sequence 1:	NP_001262337.1	Gene:	sas / 40861	FlyBaseID:	FBgn0002306	Length:	1693	Species:	Drosophila melanogaster
Sequence 2:	NP_071602.1	Gene:	Ccn2 / 64032	RGDID:	621392	Length:	347	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	83/404 - (20%)
Similarity:	120/404 - (29%)	Gaps:	152/404 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 RDCDERCTCNRGDWMCEPRCRGLSYPRGSQRSMANPNCLEKMVEEDECCRVMECSEPQLEPTVVA 613
            :||..:|.|..   ...|||     |.|.  |:....|        .||||  |::...|   :.
  Rat    25 QDCSAQCQCAA---EAAPRC-----PAGV--SLVLDGC--------GCCRV--CAKQLGE---LC 66

  Fly   614 TEG-------------AAPSTNGTGESAVTLPTTDDEATPKPRTDCHYNSGVYKFRERLEIGCEQ 665
            ||.             .:|:....|           ..|.|....|.:...||:..|..:..|:.
  Rat    67 TERDPCDPHKGLFCDFGSPANRKIG-----------VCTAKDGAPCVFGGSVYRSGESFQSSCKY 120

  Fly   666 ICHCAEGGV-------MDCR---PRCPERNHTRLDKCVYVKDPKDVCCQLELCDVTLDDHEQQPT 720
            .|.|.:|.|       ||.|   |.||.....:|         ...||:..:||        :|
  Rat   121 QCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKL---------PGKCCEEWVCD--------EP- 167

  Fly   721 PLQSNNNEDPEEIDPFRFQEQARDAGGAKPT-----CTFKGAEYDVGQQFRDGCDQLCICNEQGI 780
                   :|...:.|.....:..|..|..||     |..:..|:       ..|.:.|   ..||
  Rat   168 -------KDRTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEW-------SACSKTC---GMGI 215

  Fly   781 HCAKLECPSNFGLDVQDPHCIRWEPVPADFKPSPPNCCPESMRCVDNGTCSYQGVQIENWSPVPA 845
            ........:...|:.|...|: ..|..||.:.:    ..:..:|:.....:         .||..
  Rat   216 STRVTNDNTFCRLEKQSRLCM-VRPCEADLEEN----IKKGKKCIRTPKIA---------KPVKF 266

  Fly   846 NLTGCD-------QHC-YCENGRVECRAACPPVPALPPADLPCHPALARLLPI----PDDE---- 894
            .|:||.       :.| .|.:||      |            |.|.....||:    ||.|
  Rat   267 ELSGCTSVKTYRAKFCGVCTDGR------C------------CTPHRTTTLPVEFKCPDGEIMKK 313

  Fly   895 -------CCKHWMC 901
                   |..|:.|
  Rat   314 NMMFIKTCACHYNC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sas	NP_001262337.1	VWC	752..824	CDD:214564	12/71 (17%)
		fn3	1413..1479	CDD:278470
		FN3	1516..1605	CDD:238020
Ccn2	NP_071602.1	IGFBP	<39..80	CDD:395164	15/60 (25%)
		VWC	101..160	CDD:214564	17/67 (25%)
		TSP1_CCN	197..240	CDD:408805	9/53 (17%)
		Heparin-binding. /evidence=ECO:0000250\|UniProtKB:P29279	245..347		21/114 (18%)
		GHB_like	251..343	CDD:419725	21/104 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11348
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100