DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAGE and MAGEB16

DIOPT Version :9

Sequence 1:	NP_649702.2	Gene:	MAGE / 40860	FlyBaseID:	FBgn0037481	Length:	232	Species:	Drosophila melanogaster
Sequence 2:	NP_001093391.1	Gene:	MAGEB16 / 139604	HGNCID:	21188	Length:	324	Species:	Homo sapiens

Alignment Length:	244	Identity:	67/244 - (27%)
Similarity:	118/244 - (48%)	Gaps:	42/244 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STSRAARSQNAIPSQEAQQ--------------PVDVVDAKVRAILNYILDHTAQKIPIKDKDL- 52
            :|:.::.|..|..:||.:.              |.|.:|.||..::|::|.....|.||...|:
Human    76 TTTSSSESDEASSNQEEEDSPSSSEDTSDPRNVPADALDQKVAFLVNFMLHKCQMKKPITKADML 140

  Fly    53 -IAVAGDKSELKKRLPLVTNLLAETFGIILTPLDATTKTF------------ICTAEEPVASIHE 104
             |.:..|:|...:.|...:..|...||:.:..:|.||..:            :.:.|:.|
Human   141 KIIIKDDESHFSEILLRASEHLEMIFGLDVVEVDPTTHCYGLFIKLGLTYDGMLSGEKGV----- 200

  Fly   105 LTPAQRPQFTLLYIILMYIFLRGNRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQ 169
                  |:..||.|:|..||::|||..:.:::.:|.:..:|..::|..|| ..|..|.:.|||::
Human   201 ------PKTGLLIIVLGVIFMKGNRATEEEVWEVLNLTGVYSGKKHFIFG-EPRMLITKDFVKEK 258

  Fly   170 YLKRERSQLSAYDDSKTFFLWGPRAKAEFTFEQMVQFASKLLNQHPKVF 218
            ||  |..|::..|.::..||||||||||.:..::::|.:|:...:|..|
Human   259 YL--EYQQVANSDPARYEFLWGPRAKAETSKMKVLEFVAKVHGSYPHSF 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAGE	NP_649702.2	MAGE	36..201	CDD:279759	52/178 (29%)
MAGEB16	NP_001093391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		MAGE_N	5..90	CDD:315167	3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..108		5/31 (16%)
		MAGE	120..288	CDD:334545	53/181 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151980
Domainoid	1	1.000	63	1.000	Domainoid score	I10231
eggNOG	1	0.900	-	-		E1_KOG4562
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5087
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1195799at2759
OrthoFinder	1	1.000	-	-		FOG0000171
OrthoInspector	1	1.000	-	-		oto88564
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.900