DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAGE and MAGED2

DIOPT Version :9

Sequence 1:NP_649702.2 Gene:MAGE / 40860 FlyBaseID:FBgn0037481 Length:232 Species:Drosophila melanogaster
Sequence 2:NP_055414.2 Gene:MAGED2 / 10916 HGNCID:16353 Length:606 Species:Homo sapiens


Alignment Length:238 Identity:69/238 - (28%)
Similarity:112/238 - (47%) Gaps:31/238 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RAARSQNAIPSQEAQQP----VDVVDAKVRAILNYILDHTAQKIPIKDKDLIAVAGDKSELKKRL 66
            |||:.|:   |||.:.|    |.::..:...::.|:|.....|||||..|::     |..:|:..
Human   258 RAAKLQS---SQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIKRSDML-----KDIIKEYT 314

  Fly    67 PLVTNL-------LAETFGIILTPLDATTKTFI--CTAEEPVASIHELTPAQRPQFTLLYIILMY 122
            .:...:       |.:.|||.|..:|.....:|  .|.|...|.|.. |....|:..||.::|..
Human   315 DVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILG-TTKDSPKLGLLMVLLSI 378

  Fly   123 IFLRGNRIEDSKLYVMLEMLNIYPDEEHGYFGPNLRKQIEETFVKQQYLKRER---SQLSAYDDS 184
            ||:.|||..::.::.:|..|.:.|...|..|| :::|.|.:.||||:||...|   |....|:  
Human   379 IFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFG-DVKKLITDEFVKQKYLDYARVPNSNPPEYE-- 440

  Fly   185 KTFFLWGPRAKAEFTFEQMVQFASKLLNQHPKVFGHHLSMAQE 227
               |.||.|:..|.:..::::||.|:..:.||.:......|.|
Human   441 ---FFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAME 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAGENP_649702.2 MAGE 36..201 CDD:279759 53/176 (30%)
MAGED2NP_055414.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..204
RNase_E_G <11..161 CDD:331378
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 248..275 8/19 (42%)
MAGE 286..454 CDD:307557 53/179 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..563
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151969
Domainoid 1 1.000 63 1.000 Domainoid score I10231
eggNOG 1 0.900 - - E1_KOG4562
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1195799at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105159
Panther 1 1.100 - - LDO PTHR11736
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.750

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