Protein Alignment SMAD1 and smad1

DIOPT Version :9

• Sequence 1: NP_001003688.1
• Gene: SMAD1 / 4086
• HGNCID: 6767
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001007481.1
• Gene: smad1 / 493211
• XenbaseID: XB-GENE-1018193
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 465
• Identity: 446/465 - (95%)
• Similarity: 454/465 - (97%)
• Gaps: 1/465 - (0%)

Human     1 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCV 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCV 65

Human    66 TIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRV 130
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
 Frog    66 TIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEYPFGSKQKEVCINPYHYKRV 130

Human   131 ESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNS 195
            |||||||||||||||||||||||||||||..:|||||.|||||||||||||||||||||||||||
 Frog   131 ESPVLPPVLVPRHSEYNPQHSLLAQFRNLEPSEPHMPHNATFPDSFQQPNSHPFPHSPNSSYPNS 195

Human   196 PGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDV 260
            || |||||||||.|||||||||:|||||||||:||||.||||.|||||||||.|.:|.:|||.||
 Frog   196 PG-SSSTYPHSPASSDPGSPFQIPADTPPPAYMPPEDQMTQDNSQPMDTNMMVPNIPQDINRADV 259

Human   261 QAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIEN 325
            |||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||
 Frog   260 QAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNRNRFCLGLLSNVNRNSTIEN 324

Human   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQ 390
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||
 Frog   325 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSGCSLKIFNNQEFAQ 389

Human   391 LLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   390 LLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 454

Human   456 SPHNPISSVS 465
            ||||||||||
 Frog   455 SPHNPISSVS 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD1	NP_001003688.1	MH1_SMAD_1_5_9	9..132	CDD:199814	121/122 (99%)
		PRK10263	<133..>244	CDD:236669	100/110 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..248		77/85 (91%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	197/199 (99%)
		L3 loop. /evidence=ECO:0000269|PubMed:11779505	418..428		9/9 (100%)
smad1	NP_001007481.1	MH1_SMAD_1_5_9	9..132	CDD:199814	121/122 (99%)
		FAM70	<132..229	CDD:373433	89/97 (92%)
		MH2_SMAD_1_5_9	264..464	CDD:199822	197/199 (99%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I6822
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21196
Inparanoid	1	1.050	951	1.000	Inparanoid score	I3370
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D146758at32523
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		oto152598
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110