Protein Alignment SMAD1 and Dad

DIOPT Version :10

• Sequence 1: NP_005891.1
• Gene: SMAD1 / 4086
• HGNCID: 6767
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 459
• Identity: 115/459 - (25%)
• Similarity: 185/459 - (40%)
• Gaps: 132/459 - (28%)

Human    35 DALVKKLKKK---------KGAMEELEKALSCPGQPS--------NCVTIPRSLDGRLQVSHRKG 82
            :||:|:||:|         |..::...|......:|:        .|:.||.......:
  Fly   222 EALMKQLKRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQTVWE------ 280

Human    83 LPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRV------ESPVLPPVLVP 141
             |||...|::.|.:|.:..|||.|..|  |.......:|.||.|:.|:      |||. ||.
  Fly   281 -PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETESPT-PPY--- 338

Human   142 RHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHS 206
                   |.|.:.:.::.               .|::.:.:....:..|::.....|.|:.|
  Fly   339 -------QRSKMLRLKDA---------------DFEEDSQNDAKSAALSTWSAESTSISNIY--- 378

Human   207 PTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHW 271
                            .|..|    :.:|.||.   |.|     :.|::               |
  Fly   379 ----------------KPALY----ESVTTDGK---DHN-----INSQV---------------W 400

Human   272 CSIVYYELNNRVGEAFHASSTSVLVDGFTD--PSNNKNRFCLGLLSNVNR--NSTIENTRRHIGK 332
            |.|.|:|:.:||||.|||.:.:|.:  :||  .::..:..||..|:....  :|.:...|..:|.
  Fly   401 CQIAYWEMAHRVGEFFHAKTNAVNI--YTDGIVASEVDSMCLRDLTPAGNQIHSVVPKARHTVGL 463

Human   333 GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPT------TVCKIPSGCSLKIFNNQEFAQL 391
            ||.|....|:|:.....:::|||.|          ||      .|||:..|..||.|.... |:|
  Fly   464 GVTLSLENGDVWIYNRGNTTIFVDS----------PTLSENLDRVCKVMPGYCLKAFETNR-AEL 517

Human   392 LAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMG 455
            |:.. :||...:..:... :|::||.||||.:|.|||:...|||:|:|. |...|:|  :|.:..
  Fly   518 LSMR-DHGHHPMGPVDYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSA 578

Human   456 SPHN 459
            .||:
  Fly   579 GPHS 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD1	NP_005891.1	MH1_SMAD_1_5_9	9..132	CDD:199814	29/119 (24%)
		PRK10263	<133..>244	CDD:236669	15/110 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..248		12/85 (14%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	66/206 (32%)
		L3 loop. /evidence=ECO:0000269|PubMed:11779505	418..428		6/9 (67%)
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	29/115 (25%)
		MH2_I-SMAD	400..565	CDD:199821	60/179 (34%)