Protein Alignment SMAD1 and Mad

DIOPT Version :10

• Sequence 1: NP_005891.1
• Gene: SMAD1 / 4086
• HGNCID: 6767
• Length: 465
• Species: Homo sapiens
• Sequence 2: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Alignment Length: 467
• Identity: 351/467 - (75%)
• Similarity: 383/467 - (82%)
• Gaps: 36/467 - (7%)

Human     5 SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPR 69
            |||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||||||||.||||||
  Fly    89 SLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPR 153

Human    70 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPV 134
            ||||||||||||||||||||||||||||||||||||||.|::||.:|||||||||||||||||||
  Fly   154 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPV 218

Human   135 LPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDS-FQQPNSHPFPHSPNSSYPNSPGS 198
            |||||||||||:.|.||:| ||.::.  ||.||.|.::.:| |   |||..             |
  Fly   219 LPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGF---NSHSL-------------S 264

Human   199 SSSTYPHSPTS--SDPGSPFQMPADTPPPAYLPPEDPMT---QDGSQPMDTNMMAPPLPSEINRG 258
            :|:|...||:|  |:|.||:...|.||||||.|.||..:   .||.|.:|..|           |
  Fly   265 TSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQM-----------G 318

Human   259 DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTI 323
            ||..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||.:|.|||.||||||||||
  Fly   319 DVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTI 383

Human   324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEF 388
            ||||||||||||||||.|||||||||||:||||||||||||||||:||||||.||||||||||||
  Fly   384 ENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEF 448

Human   389 AQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 453
            ||||:||||:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   449 AQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 513

Human   454 MGSPHNPISSVS 465
            ||||||.|||||
  Fly   514 MGSPHNAISSVS 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMAD1	NP_005891.1	MH1_SMAD_1_5_9	9..132	CDD:199814	111/122 (91%)
		PRK10263	<133..>244	CDD:236669	52/116 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..248		35/91 (38%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	174/199 (87%)
		L3 loop. /evidence=ECO:0000269|PubMed:11779505	418..428		9/9 (100%)
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	111/122 (91%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	174/199 (87%)