DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMAD1 and sma-2

DIOPT Version :9

Sequence 1:	NP_001003688.1	Gene:	SMAD1 / 4086	HGNCID:	6767	Length:	465	Species:	Homo sapiens
Sequence 2:	NP_001370321.1	Gene:	sma-2 / 176229	WormBaseID:	WBGene00004856	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	241/465 - (51%)
Similarity:	291/465 - (62%)	Gaps:	66/465 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    14 VKRL---LGWKQGDEEEKWAEKAVDALVKKL-KKKKGAMEELEKALSCPG-QPSNCVTIPRSLDG 73
            :|::   |.||||||:|.||:||:|.|:||| |..|.|:|.||.||.|.| |.:.||||||||||
Worm     7 IKKITERLKWKQGDEDENWAKKAIDNLMKKLIKHNKQALENLEFALRCQGQQKTECVTIPRSLDG 71

Human    74 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESP-VLPP 137
            |||:||||.|||||||||:||||||||||||.:|.|.|.:.|.||::||||||||||.:. ||||
Worm    72 RLQISHRKALPHVIYCRVYRWPDLQSHHELKAIEDCRFCYESGQKDICINPYHYKRVHATGVLPP 136

Human   138 VLVPRHSEYNPQH--SLLAQFRNLGQNEPHMPLNATFPD-SFQQPNSHPFPHSPNSSYPNSPGSS 199
            |||||:||..||.  ..||:|:.:..:...||.|....: :|.....|.:
Worm   137 VLVPRYSEKPPQEVPPTLAKFQLMEMSGSRMPQNVNMANVNFTANQFHQY--------------- 186

Human   200 SSTYPHSPTSSDPGSPFQMPADTPP--PAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQA 262
               .|:.....|....|    |.||  |..|.|.|.:
Worm   187 ---NPNGIEEMDTSQKF----DIPPGVPTCLVPFDKV---------------------------- 216

Human   263 VAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTR 327
              :|| :.|.::.|||||.||||....|||::.:||||||..|.::..|||.||||||:||||||
Worm   217 --WEE-QFWATVSYYELNTRVGEQVKVSSTTITIDGFTDPCINGSKISLGLFSNVNRNATIENTR 278

Human   328 RHIGKGVHLYYV--GGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQ 390
            ||||.||.|.||  .|.::|:|.|||:|||||.||||.:|||.|||.||.:.||||||:.:.|.|
Worm   279 RHIGNGVKLTYVRSNGSLFAQCESDSAIFVQSSNCNYINGFHSTTVVKIANKCSLKIFDMEIFRQ 343

Human   391 LLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455
            ||......||:..::|.||..|||||||||||||.||||||||||||||||.||.|||:||:.||
Worm   344 LLEDCSRRGFDASFDLQKMTFIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVLSTMG 408

Human   456 SPHNPISSVS 465
            ....||||:|
Worm   409 PTPRPISSIS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMAD1	NP_001003688.1	MH1_SMAD_1_5_9	9..132	CDD:199814	83/122 (68%)
		PRK10263	<133..>244	CDD:236669	31/116 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..248		15/88 (17%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	126/201 (63%)
		L3 loop. /evidence=ECO:0000269\|PubMed:11779505	418..428		8/9 (89%)
sma-2	NP_001370321.1	MH1	5..130	CDD:412134	83/122 (68%)
sma-2	NP_001370321.1	MH2_R-SMAD	222..405	CDD:199820	117/182 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I1526
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1050
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm15272
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910