DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sas-4 and Tcp10b

DIOPT Version :9

Sequence 1:	NP_649701.2	Gene:	Sas-4 / 40859	FlyBaseID:	FBgn0011020	Length:	901	Species:	Drosophila melanogaster
Sequence 2:	XP_008756981.1	Gene:	Tcp10b / 308169	RGDID:	1307454	Length:	515	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	130/512 - (25%)
Similarity:	209/512 - (40%)	Gaps:	135/512 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 ERRKFEQQMRLQKSNANSKEKK--EIAALKQEVEGLQLQLKQKEQAHVSAQARLRAQLRASEKEQ 568
            |::|.|     .|:.|..::.|  |:..|::::..|..:|.::......|...|::|:.|..||.
  Rat    15 EKKKME-----AKAQAPGEDSKTDEVVGLQKQISDLGTELTRQSSWWCVAHKDLQSQIDALIKEN 74

  Fly   569 RNYRDEIELLRKENKRLEQELVKIGRENNS------KMLQEI--NRNIARLAPKVLPSATMSDIL 625
            :..|.|::.|:|:    :.|..|....:.|      .::|:|  ...||......||.......:
  Rat    75 QEIRAELQTLKKQ----DSEAPKAPTASPSPPTATNTLVQQIFCITEIAAYEGCTLPCRHSLHWV 135

  Fly   626 DENG---------------------RRTQSLDGTAGKPAKQREAQNRRQSSGSAQVRSR------ 663
            ...|                     .:|.|.|.....|:...:..:...:.|:..:..|
  Rat   136 PREGLTIINHTELTPVYIRIEGMDSEKTTSWDERDDAPSGSPQNGSTMATGGTDSLEERLSFTSL 200

  Fly   664 --------SRSLSR--NKKTPYALDES-----------YASSSSVESEEVQ------------PP 695
                    |:.|.|  .:.:|..|.:|           ::|:......|:.            ||
  Rat   201 DEKVIHMSSKFLQRGFGRLSPEPLSDSTFLDTESPADIWSSNPDTSEGEILLQARASRVLPCFPP 265

  Fly   696 VTA------PKAATPPPAANSSSDFKREITN-------------ADGSKDIWYPNGNLKKISADG 741
            ...      .|:..|.....:|...|.:.|.             :||...|.:|||..|:||||.
  Rat   266 NAVWLQNIPAKSRVPKEVQQTSDTTKEDETQEKRHSNGKVERLLSDGRTIITFPNGTRKEISADK 330

  Fly   742 MNLRMLYFNKDIKETNIREGTVK---------------------------------YYYAETNTW 773
            ....:.:||.|:|:....:...:                                 ||||:..|.
  Rat   331 KTTVIKFFNGDMKKVKSDQRVEQHDQEYLGRKDFIWLTCPHHDIEGNHHHCRKLEIYYYADAQTT 395

  Fly   774 HTSYLDGLEILEFPNGQTEHRRKDGTVEIHFPNNSIKIVDPSDTEKLEEWRYADGTHLVQLRNGD 838
            ||:|.||:|:::|||..||....||:.|..||:.::|.:    .:..||..:.|||.:...||||
  Rat   396 HTTYPDGVEVVQFPNKWTEKFYPDGSKETVFPDGTVKQL----KDGCEETVFPDGTFVTVKRNGD 456

  Fly   839 KILNLPNGQKEIHTKLNKRREYPDGTVKLVYPDGSQETRYSNGRVRLKDKDGKLIMD 895
            |.:...||||||||...||||:||||.|.||.:|.|||:|::||:|:||:.|.:|:|
  Rat   457 KTIMFSNGQKEIHTARFKRREFPDGTTKTVYCNGCQETKYASGRIRVKDETGTVILD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas-4	NP_649701.2	DUF2570	<517..>587	CDD:305162	17/71 (24%)
Sas-4	NP_649701.2	Tcp10_C	717..895	CDD:284589	79/223 (35%)
Tcp10b	XP_008756981.1	Tcp10_C	306..513	CDD:284589	78/210 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353366
Domainoid	1	1.000	159	1.000	Domainoid score	I3989
eggNOG	1	0.900	-	-		E1_2CMKS
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009891
OrthoInspector	1	1.000	-	-		otm45848
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10331
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.800