Protein Alignment Sas-4 and Cpap

DIOPT Version :10

• Sequence 1: NP_649701.2
• Gene: Sas-4 / 40859
• FlyBaseID: FBgn0011020
• Length: 901
• Species: Drosophila melanogaster
• Sequence 2: NP_001014996.2
• Gene: Cpap / 219103
• MGIID: 2684927
• Length: 1344
• Species: Mus musculus
• Alignment Length: 1148
• Identity: 280/1148 - (24%)
• Similarity: 460/1148 - (40%)
• Gaps: 357/1148 - (31%)

  Fly    24 ALSRWQDEQKRLLQERQSN------HRVLLGLEQRNMYKMLGLLHQETESHENSVLEEWD-EEHS 81
            ||.||:.:..|..:.:..|      ...::.:::|   .:...:.::.::.|:.:.|:.. ||..
Mouse   279 ALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDER---PIKAAVREKQQTFEDYLEEQIQLEERE 340

  Fly    82 IQMPRLAADPDEHEPEISMADPQPAKPKRPFLRRGEGLKQRFKINPDQLRLENLPRYKFANAHPQ 146
            ::..:|   .:...|.::     ..|||:|||:|||||.                  :|.||..:
Mouse   341 LRQKQL---QEAEGPLLA-----KTKPKQPFLKRGEGLA------------------RFTNAKSK 379

  Fly   147 FRTPQMKKGILKKQVKSPPNPAPPPAPKPSAQLDDLNEQRFQQMLIGKNACSSTPDL-------- 203
            |     :||   |:.|.....: |...:|.:::|..:.|| :..||.|:.|:.||.:
Mouse   380 F-----QKG---KESKLASTQS-PSEDQPGSKVDRQHLQR-KTALINKDLCAETPTVKKDSKARP 434

  Fly   204 KSSYAS----------STTASSTSPRVRFVEQKSRAGQTTH-ADDEASSEAS----------PMT 247
            |:.:||          :...|.:.|.::....|.|.||..| ...|.::.||          |..
Mouse   435 KAGFASLRQKPKVTKTNMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWD 499

  Fly   248 GVC--WAKV--------------------------LDTQSIKPAQIQRRSAQI--RVEDDSNVSI 282
            ..|  |:|.                          .:|:|.....:|:: .:|  |.::..|:.:
Mouse   500 AGCKMWSKTQGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKK-LEIWEREKEKENLEL 563

  Fly   283 --FELLEQKATEGNIDMNSSCIRTFMARKDQRRRVAD----DSDHIVVTQQVRQMRLQP------ 335
              |..||:.|.|.:...|||.:...:.|..|   :.|    .|..:...||....:..|
Mouse   564 DEFLFLERAADEISFSSNSSFVLRILERDQQ---ICDGHRLSSTPVKAVQQREAQQADPRGQSNC 625

  Fly   336 --------------QVDQMLV--------------------------QELQE----------GDE 350
                          :.:.||:                          .|:|.          ..:
Mouse   626 SEIPRYGVAHENESECEAMLLSWGSGSPDGLRELSCKRSMKAFQTSTSEIQSQWDARDDGVANSD 690

  Fly   351 EDTEPSSDQTLTMTP-IQVGNTKVRVRFSDSNDTHEYSDA------------------------- 389
            ..||......:|:.| .:||:   || ||:..|:.:..||
Mouse   691 SSTESEEQHDITIKPSTEVGD---RV-FSNREDSPQVCDAKGPIRDTGAQEDKWRDADLDLSDKE 751

  Fly   390 ---------TSLND-------------GSNIQLFEQFKSALFQALEQ------------------ 414
                     .|||:             ||.|. |:..:|  :..||:
Mouse   752 CSSDESVIVESLNNKVLEPLRLPSSQAGSKID-FDDERS--WTDLEENPYEHGVIHREEAIYGTP 813

  Fly   415 -----------------KKKSSPSKESDE---------PITKDL--------------------Q 433
                             |:|.:|.|:.::         |...||                    :
Mouse   814 QTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSDLMVKFFPSLKPKPKLDSHLENE 878

  Fly   434 EKANL---------------------VRTRLEELETEIATFKEQNAQLLRLRQQHELEKAKCTQD 477
            .|.||                     :|.::.|||:||..||.:|..|.:||.:.|....|..::
Mouse   879 SKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELESEIEKFKAENTSLAKLRIERESALEKLRKE 943

  Fly   478 HMEAMERVHDEKIQAEIYLHDERMKIEEERRKFEQQMRLQKSNANSKEKKEIAALKQEVEGLQLQ 542
            ..:..::...|..:.|.|..:|..|:::||:.||:.....::..:.||::||.||||::..||..
Mouse   944 IADFEQQKARELARIEEYRKEETRKLQKERKVFEKYTAAARTFPDKKEREEIQALKQQIADLQED 1008

  Fly   543 LKQKEQAHVSAQARLRAQLRASEKEQRNYRDEIELLRKENKRLEQELVKIGRENNSKMLQEINRN 607
            ||:||....|.|:|||:|:....||..:.|:||:::  |..||:........||:.|..|.:
Mouse  1009 LKRKETKWSSTQSRLRSQIEMLVKENTDLREEIKVM--ERFRLDAWKRAEAMENSPKACQYM--- 1068

  Fly   608 IARLAPKVLPSATMSDILDENGRRTQSLDGTAG-KPAKQREAQNRRQSSGSAQVRSR-SRSLSRN 670
                      .||..|....:..:.|....::| :..|.::.....|.:.|.:::|. .|.|..:
Mouse  1069 ----------MATKKDESMNSSFQFQKSHVSSGVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSS 1123

  Fly   671 KKTPYAL-----------DESYASSSSVESEEVQPPVTAPKAATPPPAANSSSDFKREITNADGS 724
            .|...||           |..|.:....| ||:|..::.|             |.|.|....:|.
Mouse  1124 DKGQAALPREPLQQVNFPDLEYKNKEEKE-EEIQGEISHP-------------DGKVEKIYKNGR 1174

  Fly   725 KDIWYPNGNLKKISADGMNLRMLYFNKDIKETNIREGTVKYYYAETNTWHTSYLDGLEILEFPNG 789
            :.:.:|||..|::||||.::.:.:||.|:|:. :.:..|.||||...|.||:|.:|||:|.|.:|
Mouse  1175 RVVLFPNGTRKEVSADGKSVTVTFFNGDVKQV-MPDERVVYYYAAAQTTHTTYPEGLEVLHFSSG 1238

  Fly   790 QTEHRRKDGTVEIHFPNNSIKIVDPSDTEKLEEWRYADGTHLVQLRNGDKILNLPNGQKEIHTKL 854
            |.|....||..||.||:.:||.:   ..:..||..:.|||.:...|:|:||:...|||:|:||..
Mouse  1239 QIEKHFPDGRKEITFPDQTIKTL---FADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQ 1300

  Fly   855 NKRREYPDGTVKLVYPDGSQETRYSNGRVRLKDKDGKLIMDTD 897
            .|||||||||||.||.:|.|||:|::||||:|||||.::|||:
Mouse  1301 FKRREYPDGTVKTVYANGHQETKYTSGRVRVKDKDGNVLMDTE 1343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sas-4	NP_649701.2	Smc	<435..>654	CDD:440809	64/240 (27%)
		YwqK	731..900	CDD:442097	81/167 (49%)
		Tcp10_C	821..850	CDD:462118	12/28 (43%)
		Tcp10_C	856..884	CDD:462118	20/27 (74%)
Cpap	NP_001014996.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..123
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..225
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..300		6/20 (30%)
		Alpha/beta-tubulin binding. /evidence=ECO:0000250|UniProtKB:Q9HC77	307..382		22/108 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	347..407		23/91 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..470		6/44 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..626		4/25 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..735		15/66 (23%)
		Interaction with STIL. /evidence=ECO:0000250|UniProtKB:Q9HC77	887..1344		162/490 (33%)
		COG4913	<901..>1046	CDD:443941	48/146 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1105..1133		8/27 (30%)
		Tcp10_C	1158..1186	CDD:462118	8/40 (20%)
		Tcp10_C	1231..1259	CDD:462118	12/27 (44%)
		Tcp10_C	1267..1295	CDD:462118	12/27 (44%)
		Tcp10_C	1302..1331	CDD:462118	21/28 (75%)