DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sas-4 and Tcp10b

DIOPT Version :9

Sequence 1:	NP_649701.2	Gene:	Sas-4 / 40859	FlyBaseID:	FBgn0011020	Length:	901	Species:	Drosophila melanogaster
Sequence 2:	NP_033367.2	Gene:	Tcp10b / 21462	MGIID:	98542	Length:	438	Species:	Mus musculus

Alignment Length:	464	Identity:	123/464 - (26%)
Similarity:	211/464 - (45%)	Gaps:	115/464 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 ERRKFEQQMRLQKSNANSKEKKEIAALKQEVEGLQLQLKQKEQAHVSAQARLRAQLRASEKEQRN 570
            |:||.|...::.:.::   :..|:..|::::..|..:|.::......|...|::|:.|..||.:.
Mouse    14 EKRKMESTAQITEEDS---KLDEVVGLQKQICDLGTELTRQSSWWCVAHKDLQSQIDALIKENQE 75

  Fly   571 YRDEIELLRKEN-------------KRLEQEL---VKI--------------------------- 592
            .|.|::.|:|::             .|....|   |||
Mouse    76 IRAELKTLKKQDAEATKACIGSPTPARASNTLPVYVKIEGIDSERTTSWDERDELSGSPPNRSTM 140

  Fly   593 ---GRENNSKML--------------QEINRNIARLAPKVLPSATMSDILDENGRRTQSLDGTAG 640
               |.::..:||              :.:.|:..|::|:.|..:|..|        |:||
Mouse   141 ATGGTDSQDEMLSFTSVDEKVIHMSSKFLQRSFGRMSPEPLSDSTFLD--------TESL----- 192

  Fly   641 KPAKQREAQNRRQSSGSAQVRSRS--------------RSLSRNKKTPYALDESYASSSSVESEE 691
               ....:.|...|.|...:.:::              :::....:.|..:.::..::.:.|::|
Mouse   193 ---ADIWSSNPETSDGELLLHAQASRVIPCFSPNALWVQNIPTKSRAPKEIQQTSDTTKTDETKE 254

  Fly   692 VQPPVTAPKAATPPPAANSSSDFKREITNADGSKDIWYPNGNLKKISADGMNLRMLYFNKDIKET 756
            .:.|                 :.|.|...:||...|.:|||..|:||||.....:.:||.|:|:.
Mouse   255 KRHP-----------------NGKVERMLSDGRTIITFPNGTRKEISADKKTTLIRFFNGDMKKI 302

  Fly   757 NIREGTVKYYYAETNTWHTSYLDGLEILEFPNGQTEHRRKDGTVEIHFPNNSIKIVDPSDTEKLE 821
            . .:..|.||||:..|.||:|.||:|:::|||..||....||:.|..||:.::|.:    .:..|
Mouse   303 K-SDQKVIYYYADAQTMHTTYPDGVEVVQFPNKWTEKFYPDGSKETVFPDGTVKQL----KDGCE 362

  Fly   822 EWRYADGTHLVQLRNGDKILNLPNGQKEIHTKLNKRREYPDGTVKLVYPDGSQETRYSNGRVRLK 886
            |..:.|||.:...|||||.:...||:|||||...||:|:||||.|.||.:|.|||:|::||||:|
Mouse   363 ETVFPDGTFVTVKRNGDKTIMFSNGEKEIHTARFKRKEFPDGTTKTVYCNGCQETKYASGRVRVK 427

  Fly   887 DKDGKLIMD 895
            |:.|.:|:|
Mouse   428 DEKGTVILD 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas-4	NP_649701.2	DUF2570	<517..>587	CDD:305162	15/82 (18%)
Sas-4	NP_649701.2	Tcp10_C	717..895	CDD:284589	79/177 (45%)
Tcp10b	NP_033367.2	DUF4527	19..>103	CDD:291689	15/86 (17%)
Tcp10b	NP_033367.2	Tcp10_C	263..436	CDD:284589	79/177 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849708
Domainoid	1	1.000	165	1.000	Domainoid score	I3892
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009891
OrthoInspector	1	1.000	-	-		otm43766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10331
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.900