DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10098 and Scrn2

DIOPT Version :9

Sequence 1:	NP_649694.1	Gene:	CG10098 / 40851	FlyBaseID:	FBgn0037472	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_001012142.1	Gene:	Scrn2 / 360612	RGDID:	1307741	Length:	423	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	115/447 - (25%)
Similarity:	165/447 - (36%)	Gaps:	136/447 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DCFVVLPENCAEGTLIIGRNAE---DEKNVNVASEVCFYDATEVLEGKTDGGASAETGGDMLR-- 64
            ||||.:|...|...:|..:|::   ||     ..||.|..            |...|.|..|:
  Rat    13 DCFVSVPPASAIPAVIFAKNSDRPRDE-----VQEVVFIP------------AGTHTPGSRLQCT 60

  Fly    65 ------------VILQKPQPGLWGGDFGANERGVALG--LTWA---AGENEAKDSDSLLGTDIVR 112
                        |||.:|. .|||.:.||||.||.:|  ..|.   .||.||     |||.|::|
  Rat    61 YIEVEQVWKTHAVILSRPS-WLWGAEMGANELGVCIGNEAVWTKEPVGEGEA-----LLGMDLLR 119

  Fly   113 LTLAVAKDVDDAVDRIGALVASHGHDNS----------KLNFIACDAAAAWLVSCSGKVWAAEKL 167
            |.|..:.....||..|..|:..:|...|          ...|:..|...||::..:|::|||:::
  Rat   120 LALERSSTAQAAVHVIAGLLDRYGQGGSCREDPEPFCYHNTFLLADRTEAWVLETAGRLWAAQRI 184

  Fly   168 EASFLRLPSGGLAVTTVVNKSSEGLDDAASFAAAH-DAEAQAPAVDW------------------ 213
            :        ||  ...:.|:.|.|.|    .:|.| :..:.|.|..|
  Rat   185 Q--------GG--ARNISNQLSIGTD----ISAEHPELRSHAKAQGWWSGQGVFDFAEVFSLTQQ 235

  Fly   214 --------------CGPKPAGDGTYTQHDMFETLRSA-------SNASSSRAATVSVLSVKGIS- 256
                          |.......|:.|...|.:.||:.       |....:.|:.||||......
  Rat   236 PVRMEAAKARFRAGCEMLQRQQGSITAEVMMDILRNKESGICMDSGGFRTTASMVSVLPQDPTKP 300

  Fly   257 C-HWFTGTPNAAESVFKPFVF----------------APNP-RISPLTQVQAEADLTL------- 296
            | |:.|.||:.:.||||||:|                |.:| ||.|..|.|.:...:|
  Rat   301 CVHFLTATPDPSRSVFKPFIFEVGVSQPPQVLSPTFGAQDPVRILPRFQTQVDRRHSLYRGHQAA 365

  Fly   297 LHKLHSQRKPAALEHLRSLELSCVDELNNYFS-LQDHASDELDELLKDCVEAEVKFY 352
            |..:..|.:....:..:|||...::.|....: .|..|..||..|.:..||.|.:.|
  Rat   366 LGLMDEQEQAQLRQEQQSLEQEGLEALRGLLTGEQTPAPQELGSLFQAFVEREHQVY 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10098	NP_649694.1	Ntn_hydrolase	73..>169	CDD:294319	36/110 (33%)
Scrn2	NP_001012142.1	Ntn_hydrolase	11..399	CDD:412394	106/422 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I4835
OMA	1	1.010	-	-		QHG47750
OrthoDB	1	1.010	-	-		D322959at2759
OrthoFinder	1	1.000	-	-		FOG0002049
OrthoInspector	1	1.000	-	-		otm45684
orthoMCL	1	0.900	-	-		OOG6_105994
Panther	1	1.100	-	-	LDO	PTHR12994
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.770