DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10098 and Scrn2

DIOPT Version :9

Sequence 1:	NP_649694.1	Gene:	CG10098 / 40851	FlyBaseID:	FBgn0037472	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	XP_017169969.1	Gene:	Scrn2 / 217140	MGIID:	1343092	Length:	443	Species:	Mus musculus

Alignment Length:	452	Identity:	113/452 - (25%)
Similarity:	158/452 - (34%)	Gaps:	144/452 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DCFVVLPENCAEGTLIIGRNAE---DEKNVNVASEVCFYDATEVLEGKTDGGA-------SAETG 59
            ||||.:|...|...:|..:|::   ||     ..||.|..|     |....|:       ..|..
Mouse    31 DCFVSVPPASAIPAVIFAKNSDRPRDE-----VQEVVFIPA-----GTHVPGSRLQCTYIEVEQV 85

  Fly    60 GDMLRVILQKPQPGLWGGDFGANERGVALG--LTWA---AGENEAKDSDSLLGTDIVRLTLAVAK 119
            |....|||.:|. .|||.:.||||.||.:|  ..|.   .|:.||     |||.|::||.|..:.
Mouse    86 GKTHAVILSRPS-WLWGAEMGANELGVCIGNEAVWTKEPVGQGEA-----LLGMDLLRLALERSS 144

  Fly   120 DVDDAVDRIGALVASHGHDNS----------KLNFIACDAAAAWLVSCSGKVWAAEKLEASFLRL 174
            ...:||..|..|:..:|...|          ...|:..|...||::..:|.:|||::::
Mouse   145 TAQEAVHVIAGLLDRYGQGGSCREDPEPFCYHNTFLLADRTEAWVLETAGSLWAAQRIQ------ 203

  Fly   175 PSGGLAVTTVVNKSSEGLDDAASFAAAH-DAEAQAPAVDW------------------------- 213
              ||  ...:.|:.|.|.|    .:|.| :..:.|.|..|
Mouse   204 --GG--ARNISNQLSIGTD----ISAEHPELRSHAKAQGWWTGQGLFDFAEVFSLTQQPVRMEAA 260

  Fly   214 -------CGPKPAGDGTYTQHDMFETLRSA-------SNASSSRAATVSVLSVKGIS-C-HWFTG 262
                   |.......|..|...|...||..       |....:.|:.||||...... | |:.|.
Mouse   261 KARFRAGCEMLQRHQGNITAEVMMGILRDKESGICMDSGGFRTTASMVSVLPQDPTKPCVHFLTA 325

  Fly   263 TPNAAESVFKPFVF----------------APNP-RISPLTQVQAEADLTL-------------- 296
            ||:.:.||||||:|                |.:| ||.|..|.:.:...:|
Mouse   326 TPDPSRSVFKPFIFEVGVSQSPQVLSPTFGAQDPVRILPRFQTRVDRRHSLYRGHQAALGLMEDE 390

  Fly   297 ------LHKLHSQRKPAALEHLRSLELSCVDELNNYFSLQDHASDELDELLKDCVEAEVKFY 352
                  |.|...:.:...||.||.|          ....|...:..|..|.:..||.|.:.|
Mouse   391 QEQAQQLRKKQQRLEQEGLEALRGL----------LTGEQTPPAQGLGSLFQAFVEREEQAY 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10098	NP_649694.1	Ntn_hydrolase	73..>169	CDD:294319	35/110 (32%)
Scrn2	XP_017169969.1	Ntn_hydrolase	29..419	CDD:382028	106/427 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4929
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47750
OrthoDB	1	1.010	-	-		D322959at2759
OrthoFinder	1	1.000	-	-		FOG0002049
OrthoInspector	1	1.000	-	-		otm43611
orthoMCL	1	0.900	-	-		OOG6_105994
Panther	1	1.100	-	-	LDO	PTHR12994
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.800