DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and HKR1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_010708.1	Gene:	HKR1 / 852030	SGDID:	S000002828	Length:	1802	Species:	Saccharomyces cerevisiae

Alignment Length:	1489	Identity:	338/1489 - (22%)
Similarity:	568/1489 - (38%)	Gaps:	386/1489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 SSDS--CSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSSGSGVSSS 319
            |:|:  .:|....|:||.:.:|::      .||:||: ...|.:.:||.....||....||.::.
Yeast    23 SNDTIYSTSYNNGIESTPSYSTSA------ISSTGSS-NKENAITSSSETTTMAGQYGESGSTTI 80

  Fly   320 AKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLP----GSSNIGNISN 380
            ..::::..||:..|.::::.:|.|       .|||.. |....|...|::|    ..|:...||.
Yeast    81 MDEQETGTSSQYISVTTTTQTSDT-------MSSVKK-STEIATPSSSIVPTPLQSYSDESQISQ 137

  Fly   381 SLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQ-------STSSQSSTAPGTTKSSASSSSS 438
            :|::|....:.|.|...:....|..|||.|...|..       :|.||.|...||...::|.|.:
Yeast   138 TLSHNPKSVAESDSDTTSSESSSSVIISTSDSSAVPREISPIITTDSQISKEEGTLAQTSSISET 202

  Fly   439 SSNSYKEKHSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREK---SSSKLSKN 500
            :..:........:|..|::...||  .|:.|...:|:|     |.|..:|..|:   |.|:||:
Yeast   203 TRIAQMVTRVSQISSITAASTIDG--FSSESTQTDFSN-----TVSFENSVEEEYAMSKSQLSE- 259

  Fly   501 KDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHT 565
                                    |.:|::|..|||      .|.|...:|:| .|:..|:::.|
Yeast   260 ------------------------SYSSSSTVYSGG------ESTADKTSSSP-ITSFSSSYSQT 293

  Fly   566 LSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVND-STGGFGSN--------SNS 621
            .||..:.:...|..:...|:::.::|   .|..|:|....||..| |.|.:...        ::|
Yeast   294 TSTETSESSRVAVGVSRPSSITQTTS---IDSFSMSEVELSTYYDLSAGNYPDQELIVDRPATSS 355

  Fly   622 ERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSK 686
            ..|..|.|....|....|.|     |||.:.||...:   |:|.|..|.:||:|...||.:|:..
Yeast   356 TAETSSEASQGVSRESNTFA-----VSSISTTNFIVS---SASDTVVSTSSTNTVPYSSVHSTFV 412

  Fly   687 KRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTH 751
            ...:.|...:||:.:|.|.   :.|:.|.:.:.....|....:.....:..            |:
Yeast   413 HATSSSTYISSSLYSSPSL---SASVSSHFGVAPFPSAYISFSSVPVAVSS------------TY 462

  Fly   752 QTSATAEVNAPLASSTSASIAVTASATAASAP--PATGTTTLGSSISGNAGSTSSGNSSGVSATG 814
            .:|.:|.|..|.|.::|.|:.|..|:|..|:|  ||..::|..||.|... :.||..:|..||..
Yeast   463 TSSPSASVVVPSAYASSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPV-AVSSTYTSSPSAPA 526

  Fly   815 GAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPS 879
            ...|...|.  |....:.||...|:.|...:.|:|.:          ||.|...|.:::.:|:||
Yeast   527 AISSTYTSS--PSAPVAVSSTYTSSPSAPAAISSTYT----------SSPSAPVAVSSTYTSSPS 579

  Fly   880 LYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFH 944
            ..|::..:..:.|.:.:..|||.:|:.|...:.||.
Yeast   580 APVAISSTYTSSPSVPVAVSSTYTSSPSAPAAISST----------------------------- 615

  Fly   945 GGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQ 1009
              .||:.|:.|....:..|||:....:|                     :|.|.|.::.::....
Yeast   616 --YTSSPSAPVAVSSTYTSSPSAPAAIS---------------------STYTSSPSVPVAVSST 657

  Fly  1010 TTRVQQLQEQEAPPARRSRSRSGESGSSHHHAHAHHHHHHPTHHNSHHQQNPQQQQQLHQQQQQN 1074
            .|     ....||.|..|...|..|              .|...:|.:..:|            :
Yeast   658 YT-----SSPSAPAAISSTYTSSPS--------------VPVAVSSTYTSSP------------S 691

  Fly  1075 ASSHMHACTNSSSSTSTSTTSSSLSGGTAPAT-SSSNSKGPSRSGKKRGAAMNKSESTSVATTAT 1138
            |.:.:.:...||.|...:.:|:..|..:|||. ||:.:..||        |.....||..::.:.
Yeast   692 APAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPS--------APVAVSSTYTSSPSA 748

  Fly  1139 PATVAATPAEKQSRHSSPHYSATPTPP----PTSTLPPVVSSPVVMLQSLSSSS---IDSPPATA 1196
            ||.:::|            |:::|:.|    .|.|..|   |.:|:|.|.|:||   |...|:|.
Yeast   749 PAAISST------------YTSSPSAPVAVSSTYTSSP---SALVVLSSTSTSSPYDIVYSPSTF 798

  Fly  1197 AAGATSNSRNTRNNSSNGNHNGEQTSSSSSSSSSSSSGGGGTSGAANVVNLLDSPVNMSASGNYR 1261
            ||            .|:|.......|.:.||:||||        ..::|..|.|..:.|:...|.
Yeast   799 AA------------ISSGYTPSPSASVAMSSTSSSS--------PYDIVYSLSSSASRSSIATYE 843

  Fly  1262 SSSNSTGNALPAAS------------------SNASQAKP--LNKKMLRAQ----QTQLYQQQQQ 1302
            .|. |...:||.:|                  |..|...|  ::..:.|..    ||.:..|...
Yeast   844 FSP-SPSTSLPTSSTYTYFSSAYAFEFSSERYSTTSTIAPTQIHSTLSRITDFLLQTSMAIQSIV 907

  Fly  1303 QQQ------------------YAPPARS-------ISPTNLSSASASNSASLTHLQQQQQSHQQH 1342
            .||                  :.|.|.:       ||.|..|..|..|||.::.||.|..|..:
Yeast   908 SQQISTSSTLNDEIHSSALSVFNPSASNLVETSLIISSTQASITSPKNSAKISSLQSQLSSSTK- 971

  Fly  1343 EDLEILQFTNTNTTASSNTPTS----------------KPNNRTL-----DLSTASASSSSPS-A 1385
                     |...||:.||.||                ||:|...     :::|.|:||.:.| :
Yeast   972 ---------NPYDTANKNTETSGRSTVVSNFLYTSSAAKPDNEKFSATPTEITTISSSSHAYSLS 1027

  Fly  1386 VPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIKDSPPSSPGSEIGSAM 1450
            :|::.:.:..||:....:|.:|:|      |.|.|.:        :|:||.|..:.|.|:
Yeast  1028 IPSSHNSVTGLSHNFVDSSKSATS------FGYSSSS--------ISSIKLSKETIPASK----- 1073

  Fly  1451 HSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAAALSNSQQDLKDVRILQNG 1515
             |.:.....:|..::...|...:.:..||.:..:..::..::..:.:  :|::.|.|.:....:.
Yeast  1074 -SVSNTQERITSFTSTLRANSQSEKSEGRNSVGSLQSSHISSNPSLS--TNTKVDSKSLSRKVSK 1135

  Fly  1516 ASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTAAHMLGNQINPNSSVAQKLSEQLHMEVQDH 1580
            .....|...|.|.|.....:||....|.|...|..:       |.|.::..|       .:...:
Yeast  1136 TMGENGEETGLTTTKTQYKSSSETSGSYSRSFTKIS-------IGPATTAVQ-------TQASTN 1186

  Fly  1581 SIYTPDSMNSQYAGVPFPGKQRNSTA-------VPSNATPAQNPLQSMFSGGGMNGNMP 1632
            |::|..:: |.|...|:|..  ||.|       |.|:.|   .|..:.|: ..:.|::|
Yeast  1187 SVFTAPAL-STYPTTPYPSP--NSYAWLPTAIIVESSET---GPTTASFN-PSITGSLP 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142
HKR1	NP_010708.1	PLN02217	<397..506	CDD:215130	30/123 (24%)
HKR1	NP_010708.1	PHA03307	452..>776	CDD:223039	95/454 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000