DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and MLLT10

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_024303947.1	Gene:	MLLT10 / 8028	HGNCID:	16063	Length:	1102	Species:	Homo sapiens

Alignment Length:	1471	Identity:	393/1471 - (26%)
Similarity:	557/1471 - (37%)	Gaps:	470/1471 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SSKDDTIHSTSLNKKLVKIKKFKLDDMKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACY 92
            |.:|:..||                 ||||:||||||||||||.|||||||||..|:||||||||
Human     9 SLEDEVSHS-----------------MKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACY 56

  Fly    93 GIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTME 157
            |||.||||||:|||||||||.:||||||||.:|||||:|||.||||||||||||||:|.||:|||
Human    57 GIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTME 121

  Fly   158 PIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLD 222
            ||:|..:|.:||:||||||.|.|:.::|..||||.|||..|:|.|||||||..||||||.||..|
Human   122 PIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGAD 186

  Fly   223 NVKYCGYCQHHYSKLKK---GGNVKTIPPYKPIQHDTS-SDSCSSPE-----------KEID--- 269
            ||:|||||::|:|||||   |.|         ..:|.| |||.|..:           ||.|
Human   187 NVQYCGYCKYHFSKLKKSKRGSN---------RSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHK 242

  Fly   270 -----------STMNSATTSATIIKITSSSGSAGGSSNVLNASSS-------AGISAGSSSGSGV 316
                       :.:.|.|.:......::|:.|..||...|..:::       ..:||.:|||..|
Human   243 QKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTTARFTNANFQEVSAHTSSGKDV 307

  Fly   317 SSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNS 381
            |.:  :.......|||:.||.......||..||                |:.:..:|
Human   308 SET--RGSEGKGKKSSAHSSGQRGRKPGGGRNP----------------GTTVSAAS-------- 346

  Fly   382 LNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEK 446
               ..|.||.|         |:.|.:.:|||.:.||.....|......::.:.|.|..|::.|:.
Human   347 ---PFPQGSFS---------GTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYSHSQQSSATKDV 399

  Fly   447 HSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATS 511
            |.             |:..|.....|:|                                 |...
Human   400 HK-------------GESGSQEGGVNSF---------------------------------STLI 418

  Fly   512 SLSTTSSINTQPSS---------STSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLS 567
            .|.:||::.:||.|         ::|..|||       ...:..||:..  .|..|.....:..|
Human   419 GLPSTSAVTSQPKSFENSPGDLGNSSLPTAG-------YKRAQTSGIEE--ETVKEKKRKGNKQS 474

  Fly   568 TNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSS 632
            .:|.|........::||:||.||:           |.:|:|..:.|...|:|..:...|...||.
Human   475 KHGPGRPKGNKNQENVSHLSVSSA-----------SPTSSVASAAGSITSSSLQKSPTLLRNGSL 528

  Fly   633 ASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRK-------A 690
            .|     ::.|:..|.|..:.....:....:::.:..|.:.....|.||..:.::.|       .
Human   529 QS-----LSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNDRGDSSTLTKQELKFIVYLEFI 588

  Fly   691 DSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSA 755
            ..|.|:.::...|.           |:..||.|:      |...:..|.              |:
Human   589 KWAYSSQNLRNEGI-----------YNSNDVAVS------FPNVVSGSG--------------SS 622

  Fly   756 TAEVNAPLASSTSASI----AVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGA 816
            |...::.|...:|..:    |::.||.:::||..  .||..:::||::.|.:..:..|
Human   623 TPVSSSHLPQQSSGHLQQVGALSPSAVSSAAPAV--ATTQANTLSGSSLSQAPSHMYG------- 678

  Fly   817 QSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKD-ISSSSNQQASTASSSSAPSL 880
                           ..|.::.|...:.|.:|.:....|.|.:: :...|:.:.|.:..|...||
Human   679 ---------------NRSNSSMAALIAQSENNQTDQDLGDNSRNLVGRGSSPRGSLSPRSPVSSL 728

  Fly   881 YVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHG 945
            .:..     :.||                              ...|.|.   ||:..|......
Human   729 QIRY-----DQPG------------------------------NSSLENL---PPVAASIEQLLE 755

  Fly   946 GTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQT 1010
            ...|.|...:::|  |..|..||.|.|                   |.....|:..|:...:..|
Human   756 RQWSEGQQFLLEQ--GTPSDILGMLKS-------------------LHQLQVENRRLEEQIKNLT 799

  Fly  1011 T---RVQQLQEQEAPPARRSRSRSGESGSSHHHAHAHHHHHHPTHHNSHHQQNPQQQQQLHQQQQ 1072
            .   |:|.|..|.:.|                         .||     ...||....|:|
Human   800 AKKERLQLLNAQLSVP-------------------------FPT-----ITANPSPSHQIH---- 830

  Fly  1073 QNASSHMHACTNSSSSTSTSTTSSSLSGGTAPATSSSNSKGPSRSGKKRGAAMNKSESTSVATTA 1137
                                    :.|..|||.|.|                :|.|:|..:..:.
Human   831 ------------------------TFSAQTAPTTDS----------------LNSSKSPHIGNSF 855

  Fly  1138 TPATVAATPAEKQ----SRHSSPHYSATPTPPPTSTLPPVVSSPVVMLQSLSSSSI--------- 1189
            .|..  :.|...|    |..|:...||..||||....|....|.|..:|.::..::
Human   856 LPDN--SLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGALASGMQP 918

  Fly  1190 --DSPPATAAAGATSNSRNTRNNSSNGNHNGEQTSSSSSSSSSSSSGGGGTSGAANVVNLLDSPV 1252
              .:.||.:|.|...           |...|.|.:.:            |..||.|  .::.:||
Human   919 VTSTIPAVSAVGGII-----------GALPGNQLAIN------------GIVGALN--GVMQTPV 958

  Fly  1253 NMSASGNYRSSSNSTGNA---LPAASSNASQAKPLNKKMLRAQQTQLYQQQQQQQQYAPPARSIS 1314
            .||.:....:.:....||   :||..:|::....|    |..||.|:...|||.||..
Human   959 TMSQNPTPLTHTTVPPNATHPMPATLTNSASGLGL----LSDQQRQILIHQQQFQQLL------- 1012

  Fly  1315 PTNLSSASASNSASLTHLQQQ-------QQSHQQHEDLEILQFTNTNTTASSNTPTSKPNNRTLD 1372
                      ||..||..|.|       |..||||...|:.|.....       ||..|.|..|
Human  1013 ----------NSQQLTPEQHQAFLYQLMQHHHQQHHQPELQQLQIPG-------PTQIPINNLL- 1059

  Fly  1373 LSTASASSSSPSAVPATTSPLVVLSNQLPLNSVA-ASSSTG 1412
                 |.:.:|....|||:|.:.:........|| .|..||
Human  1060 -----AGTQAPPLHTATTNPFLTIHGDNASQKVARLSDKTG 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	40/46 (87%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	80/114 (70%)
MLLT10	XP_024303947.1	PHD_AF10_AF17	24..71	CDD:277049	40/46 (87%)
		RanBP2-type Zn finger	66..85	CDD:275375	15/18 (83%)
		ePHD_AF10	78..206	CDD:277178	89/127 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	388	1.000	Inparanoid score	I2025
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004366
OrthoInspector	1	1.000	-	-		otm40544
orthoMCL	1	0.900	-	-		OOG6_105638
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.050