Protein Alignment Alh and JADE1

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_024309986.1
• Gene: JADE1 / 79960
• HGNCID: 30027
• Length: 857
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 159/680 - (23%)
• Similarity: 233/680 - (34%)
• Gaps: 181/680 - (26%)

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            |.||....|...|.:|:||  .|.:.||||||||:.||.|.|.||.|....:.   :|.|||.:.
Human   221 CDVCQSPDGEDGNEMVFCD--KCNICVHQACYGILKVPEGSWLCRTCALGVQP---KCLLCPKKG 280

  Fly   126 GALKKTDNSG--WAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANV 187
            ||:|.| .||  |.||.|||:||||..|:...||||. :|.||..|::..|.:|.|       ..
Human   281 GAMKPT-RSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNE-------KF 337

  Fly   188 GACMQCNKSNCKQQFHVTCAQSLGL-----LCEEAGNYLDNVKYCGYCQHHYS------KLKKG- 240
            ||.:||:..||:..||||||...||     |.|.     |.||:..||..|.|      .|.||
Human   338 GASIQCSVKNCRTAFHVTCAFDRGLEMKTILAEN-----DEVKFKSYCPKHSSHRKPEESLGKGA 397

  Fly   241 ---GNVKTIPPYKPIQ------------HDTS----------------------SDSCSSPEKEI 268
               .......|..|::            |..|                      :.:...||:.:
Human   398 AQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVV 462

  Fly   269 D------STMNSATTSATII--KITSSSGSAGGSSNVL------------NASSSAGISAGSSSG 313
            |      ........:..:|  |.......|....:||            :......::...:..
Human   463 DFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRR 527

  Fly   314 SGVSSSA----------------KQRKSNASSKSSSSSSSS----SSSSTG-GAPNPSSSSVHSG 357
            ..:..|.                ::|.|...|..||||..:    :|.|.| .||.......||.
Human   528 EKIKRSVCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSA 592

  Fly   358 SASNMTGGGSVLPGSSNIGNISNSLN--------NNLPGGSSST-SSAGNVPGGSGGIISASSGG 413
            ......|...|           :||.        .|.||....| ....::.|...|::...|..
Human   593 FFRKQMGTSLV-----------HSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPESFL 646

  Fly   414 ATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDS-----STNSANNN 473
            ..:.|.:::.......|:...............|...:....  |||..|.|     ||:.:..:
Human   647 GLEKTFAEARLISAQQKNGVVMPDHGKRRDNRFHCDLIKGDL--KDKSFKQSHKPLRSTDVSQRH 709

  Fly   474 FTNSSASST---SSNSSSTREKSSSKLSKNKDSNQVPSATSSL------STTSSINTQPSSSTST 529
            ..|:.|:::   ..::..||::.            ||....||      .|...:.|.|:|...
Human   710 LDNTRAATSPGVGQSAPGTRKEI------------VPKCNGSLIKVNYNQTAVKVPTTPASPVK- 761

  Fly   530 ATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNL--SNSSSG 592
               ..||..............:.....::||::.:      .|.|....|.::.|.|  .|.:.|
Human   762 ---NWGGFRIPKKGERQQQGEAHDGACHQHSDYPY------LGLGRVPAKERAKSKLKSDNENDG 817

  Fly   593 FGSDLRSVSTSS----------SSTVNDST 612
            :..|:....:.|          |||::..|
Human   818 YVPDVEMSDSESEASEKKCIHTSSTISRRT 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/45 (51%)
		ePHD_AF10_like	118..233	CDD:277142	53/122 (43%)
		CC_AF10	1636..1699	CDD:411015
JADE1	XP_024309986.1	COG5141	114..>544	CDD:227470	95/340 (28%)
		ePHD_JADE1	270..387	CDD:277174	55/132 (42%)