Protein Alignment Alh and Brpf1

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_006506845.1
• Gene: Brpf1 / 78783
• MGIID: 1926033
• Length: 1253
• Species: Mus musculus
• Alignment Length: 1113
• Identity: 231/1113 - (20%)
• Similarity: 358/1113 - (32%)
• Gaps: 340/1113 - (30%)

  Fly    15 KIPSSFNAKLELDSSKDDTIHSTSLNKKL---------VKIKKFKLD--------------DMKE 56
            |.....:.::|.|..::|.|....:|::.         .:|.::.:|              |...
Mouse   203 KSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNA 267

  Fly    57 MV---GGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRC 118
            :|   ..||:|:|......|.:::||  .|.:||||.|||:..:|.|.|.||:| .|..:..|.|
Mouse   268 LVDEDAVCCICNDGECQNSNVILFCD--MCNLAVHQECYGVPYIPEGQWLCRRC-LQSPSRAVDC 329

  Fly   119 ELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPI-ILSLIPQERYSKTCYICQEIGKP 182
            .|||::.||.|:||:..||||||||:||||.|.|...:||| .:..||..|:..|||||::.|.
Mouse   330 ALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGS- 393

  Fly   183 NRANVGACMQCNKSNCKQQFHVTCAQSLGL------LCEEAGNYLD-NVKYCGYCQHHYSKLKKG 240
                 |||:||:|:||...|||||||..||      :.|...|... :|:...||..|    ...
Mouse   394 -----GACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIH----TPP 449

  Fly   241 GNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAG 305
            |:.:.:|   .:.|       |..|:|.|.              ....|.:..|..|..|.:.:.
Mouse   450 GSARRLP---ALSH-------SEGEEEEDE--------------EEDEGKSWSSEKVKKAKAKSR 490

  Fly   306 IS--------AGSSSGSGVSS---------------SAKQRKSNASSKSSSSSSSSSSSSTGGAP 347
            |.        |...:.:.|.|               ...||||....: ..|..:....|..|.|
Mouse   491 IKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQR-LHSYWTLKRQSRNGVP 554

  Fly   348 NPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSS-------------------- 392
            .......|..|..|          ...:|..|:..|..|.....|
Mouse   555 LLRRLQTHLQSQRN----------CEQVGRDSDDKNWALKEQLKSWQRLRHDLERARLLVELIRK 609

  Fly   393 -----------------------------------TSSAGNVPGGSGGIISASSGGATQSTSSQS 422
                                               ....||:          .|.....|..::.
Mouse   610 REKLKRETIKIQQIAMEMQLTPFLILLRKTLEQLQEKDTGNI----------FSEPVPLSEVTEL 664

  Fly   423 STAPG------------TTKSSASS-------------SSSSSNSYK----------------EK 446
            ...|.            |.|.:..:             :...||..|                |:
Mouse   665 DEVPDYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQ 729

  Fly   447 HSKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATS 511
            ....|.::....:|.|.|..|.....:  |.:....|.::....|:....|.:|:....|.....
Mouse   730 GGAVLRQARRQAEKMGIDFETGMHIPH--NLAGDEVSHHTEDAVEEERLVLLENQKHLPVEEQLK 792

  Fly   512 SLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSA 576
            .|     :......:.|..:.|        .|..|..:....:.......|......:|......
Mouse   793 LL-----LERLDEVNASKQSVG--------RSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGP 844

  Fly   577 AGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSS---ASNMPG 638
            :|:    .||:...:....|.::.|.:..|:..:::.|.|.|.:|...:..|..:|   :...|.
Mouse   845 SGR----GNLTPHPAACDKDGQTDSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPK 905

  Fly   639 TIAP--GTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSIST 701
            |..|  ..|....:..:.::.:.|||...........|.        ..:||......|:||.|.
Mouse   906 TAGPPKRPGRPPKNRESQMTPSHGGSPVGPPQLPIMGSL--------RQRKRGRSPRPSSSSDSD 962

  Fly   702 SGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSATAEVNAPLASS 766
            |..:.||     ...|:        |...|      ||..|..:.|...::.    :.|.|.:||
Mouse   963 SDKSTED-----PPMDL--------PANGF------SSGNQPVKKSFLVYRN----DCNLPRSSS 1004

  Fly   767 TSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESS 831
            .|.|   ::|:::::|...|.||.                    |..|..:.:...|.:|:..|.
Mouse  1005 DSES---SSSSSSSAASDRTSTTP--------------------SKQGRGKPSFSRGTFPEDSSE 1046

  Fly   832 KSSGT------ASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTAN 890
            .:|||      ...|.|.|.||.....|.|     :..:..|                   ..|:
Mouse  1047 DTSGTENEAYSVGTGRGVGHSSKYPHPKSG-----VLGTQFQ-------------------GLAS 1087

  Fly   891 VPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNAL-----------------VGPPMGG 938
            .|..:.|..|.|.....:|   ..|.:|..|:.:....:||                 :.|.| .
Mouse  1088 PPAADPPPLSRSCEVVRKS---LGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKM-P 1148

  Fly   939 SAGAFHGG 946
            ..|.||.|
Mouse  1149 REGMFHHG 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/46 (43%)
		ePHD_AF10_like	118..233	CDD:277142	57/122 (47%)
		CC_AF10	1636..1699	CDD:411015
Brpf1	XP_006506845.1	SFP1	<20..50	CDD:227516
		COG5141	173..656	CDD:227470	125/510 (25%)
		ePHD_BRPF1	329..449	CDD:277171	58/129 (45%)
		Bromo_brd1_like	631..734	CDD:99944	11/112 (10%)
		PWWP_BRPF1	1122..1241	CDD:438984	8/36 (22%)