DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and BRPF1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_024309509.1	Gene:	BRPF1 / 7862	HGNCID:	14255	Length:	1254	Species:	Homo sapiens

Alignment Length:	1223	Identity:	245/1223 - (20%)
Similarity:	372/1223 - (30%)	Gaps:	400/1223 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KIPSSFNAKLELDSSKDDTIHSTSLNKKL---------VKIKKFKLD--------------DMKE 56
            |.....:.::|.|..::|.|....:|::.         .:|.::.:|              |...
Human   204 KSAEELDEEVEYDMDEEDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNA 268

  Fly    57 MV---GGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRC 118
            :|   ..||:|:|......|.:::||  .|.:||||.|||:..:|.|.|.||:| .|..:..|.|
Human   269 LVDEDAVCCICNDGECQNSNVILFCD--MCNLAVHQECYGVPYIPEGQWLCRRC-LQSPSRAVDC 330

  Fly   119 ELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPI-ILSLIPQERYSKTCYICQEIGKP 182
            .|||::.||.|:||:..||||||||:||||.|.|...:||| .:..||..|:..|||||::.|.
Human   331 ALCPNKGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGS- 394

  Fly   183 NRANVGACMQCNKSNCKQQFHVTCAQSLGL------LCEEAGNYLD-NVKYCGYCQHHYSKLKKG 240
                 |||:||:|:||...|||||||..||      :.|...|... :|:...||..|    ...
Human   395 -----GACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIH----TPP 450

  Fly   241 GNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAG 305
            |:.:.:|   .:.|....:.....|.|                     |....|..|..|.:.:.
Human   451 GSARRLP---ALSHSEGEEDEDEEEDE---------------------GKGWSSEKVKKAKAKSR 491

  Fly   306 IS--------AGSSSGSGVSS---------------SAKQRKSNASSKSSSSSSSSSSSSTGGAP 347
            |.        |...:.:.|.|               ...||||....: ..|..:....|..|.|
Human   492 IKMKKARKILAEKRAAAPVVSVPCIPPHRLSKITNRLTIQRKSQFMQR-LHSYWTLKRQSRNGVP 555

  Fly   348 NPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSS-------------------- 392
            .......|..|..|          ...:|..|...|..|.....|
Human   556 LLRRLQTHLQSQRN----------CDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRK 610

  Fly   393 -----------------------------------TSSAGNVPGGSGGIISASSGGATQSTSSQS 422
                                               ....||:          .|.....|..::.
Human   611 REKLKRETIKVQQIAMEMQLTPFLILLRKTLEQLQEKDTGNI----------FSEPVPLSEVTEL 665

  Fly   423 STAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDK--------DGKDSSTNSANNNFTNSSA 479
            ...|               .|.:...|.:...|..::.        |..:...|...:|....:|
Human   666 DEVP---------------DYLDHIKKPMDFFTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNA 715

  Fly   480 SSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSS 544
            ..|....::.|.:........:...|.........|...|   |.|.       :|...||.:..
Human   716 KDTIFYRAAVRLREQGGAVLRQARRQAEKMGIDFETGMHI---PHSL-------AGDEATHHTED 770

  Fly   545 AASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVN 609
            ||...........:|......|..          .|:.:..::.|....|...|:.......|
Human   771 AAEEERLVLLENQKHLPVEEQLKL----------LLERLDEVNASKQSVGRSRRAKMIKKEMT-- 823

  Fly   610 DSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTS 674
                       :.|..|:....:..:.|....|.:.|  |......:.:|.|.:.|.|...:|..
Human   824 -----------ALRRKLAHQRETGRDGPERHGPSSRG--SLTPHPAACDKDGQTDSAAEESSSQE 875

  Fly   675 TSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSS 739
            ||.|...|.|               ||....:....|::  :..|:.:.|..|     |...:..
Human   876 TSKGLGPNMS---------------STPAHEVGRRTSVL--FSKKNPKTAGPP-----KRPGRPP 918

  Fly   740 KRQRTELSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSS 804
            |.:.:::: |:|..|.......|:.||      :.......|..|                |:||
Human   919 KNRESQMT-PSHGGSPVGPPQLPIMSS------LRQRKRGRSPRP----------------SSSS 960

  Fly   805 GNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQA 869
            .:.|..|                ||.......|:..||.......|...:.::.....|||:.::
Human   961 DSDSDKS----------------TEDPPMDLPANGFSGGNQPVKKSFLVYRNDCSLPRSSSDSES 1009

  Fly   870 STASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGP 934
            |::|||||                                  ||.|:|...|:..:       |.
Human  1010 SSSSSSSA----------------------------------ASDRTSTTPSKQGR-------GK 1033

  Fly   935 PMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTES 999
            |      :|..||....||   :..||..:.|    .|..:|..:..:|.||.|...:..|
Human  1034 P------SFSRGTFPEDSS---EDTSGTENEA----YSVGTGRGVGHSSKFPCPRPGMLGT---- 1081

  Fly  1000 GNLKISYEKQTTRVQQLQEQEAPPA-------------RRSRSRSGESGSSHHH----------- 1040
                           |.|...:|||             |:|..| |....|...
Human  1082 ---------------QCQGLASPPAADPPPLPHSCEVVRKSLGR-GAGWLSEDEDSPLDALDLVW 1130

  Fly  1041 AHAHHHHHHPT-------------HHNSHHQQNPQQQQQLHQQQQQNASSHMH 1080
            |....:..:|.             ||.......|.:..:|.:|..|.|..|::
Human  1131 AKCRGYPSYPALIIDPKMPREGMFHHGVPIPVPPLEVLKLGEQMTQEAREHLY 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/46 (43%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	57/122 (47%)
BRPF1	XP_024309509.1	SFP1	<20..52	CDD:227516
		COG5141	174..657	CDD:227470	123/510 (24%)
		ePHD_BRPF1	330..450	CDD:277171	58/129 (45%)
		Bromo_brd1_like	632..735	CDD:99944	14/127 (11%)
		BR140_related	1123..1238	CDD:99900	10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950