DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and jade3

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_012812727.1	Gene:	jade3 / 779948	XenbaseID:	XB-GENE-978173	Length:	824	Species:	Xenopus tropicalis

Alignment Length:	780	Identity:	168/780 - (21%)
Similarity:	258/780 - (33%)	Gaps:	238/780 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            |.||........|.:|:||  .|.:.||||||||:.||.|.|.||.|   ......:|.|||...
Frog   212 CDVCRSPDSEEGNDMVFCD--RCNICVHQACYGILKVPEGSWLCRTC---VLGLHPQCILCPKTG 271

  Fly   126 GALKKT-DNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVG 188
            ||:|.| ..:.||||.|||:||||.......||||. :|.||..|::..|.:|       :...|
Frog   272 GAMKATRTGTKWAHVSCALWIPEVSIACPERMEPITKVSHIPPSRWALVCSLC-------KLKTG 329

  Fly   189 ACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQ 253
            ||:||:..:|...||||||....|..:...:..|.||:..||..| ||.|.|...:...|
Frog   330 ACIQCSVKSCITAFHVTCAFEHSLEMKTILDEGDEVKFKSYCLKH-SKNKHGLISEQEEP----- 388

  Fly   254 HDTSSDSCSSPE----------KEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISA 308
            |.|.||:..:..          ||::...      .|::|:...:...|.....::.
Frog   389 HKTHSDNRPTESERTSLRAQKLKELEEDF------YTLVKVEDVAAELGLPMLTVDF-------- 439

  Fly   309 GSSSGSGVSSSAK-QRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSG--------------- 357
                   :.|..| :||||.:....:......:    |...|...|:|:.
Frog   440 -------IYSFWKLKRKSNFNKPLLTPKEDEQN----GLVQPKEDSIHTRMRMFMHLRQDLERVR 493

  Fly   358 --------------SASNMTGGGSVLPGSSNIGNISNSL-NNNLPGGSSSTSSAGNV-------- 399
                          |.|.|         ...|.|:...| |..:..|...:::..|.
Frog   494 NLCYMVNRREKLKLSHSKM---------HEEIFNLQVQLVNQEVAAGQPLSNALENTLFYPPPRI 549

  Fly   400 --------PGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTS 456
                    |......||:...|...|..:|:|:|      :........:....:|:|..|...|
Frog   550 TLKLKMPKPRTRDCRISSVKAGTMSSPDNQNSSA------TYHGMGGEVHRQSSEHTKLYSTYAS 608

  Fly   457 SKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINT 521
            .:..:|........:..|..:..      ..|:|.:||.|               .:|..:.|:.
Frog   609 EQRNNGLLGGITRFHKEFQGTGC------KPSSRFRSSGK---------------PMSLQAVIHG 652

  Fly   522 QPSSSTSTATAGSGGT-GTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSN 585
            |.|:       |||.. ..|||.:.|:|
Frog   653 QSSN-------GSGKVQHEHVSLARANG------------------------------------- 673

  Fly   586 LSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSS 650
                          |.:|...|..||:.......|||                 |.....|.|:.
Frog   674 --------------VLSSGDRTQRDSSSQTSPGQNSE-----------------IICHIAGQSTF 707

  Fly   651 AATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADS------AKSTSSISTSGSALEDN 709
            ...|:.........:|.|.:.:|     ....||.|.::..|      :|..:...|||:..:||
Frog   708 RKANMEHFSRSFKEATNNLVRTT-----EDLRSSEKPQRRQSVKERLWSKQPADTQTSGTPYQDN 767

  Fly   710 NSLISRYDIKDVQVALTPLTDFEKEIEKSSKR---QRTELSPPTHQTSATAEVNAPLASSTSASI 771
            :..     ..|::     |:|.|.|.:::...   :|.....|...:...:.:......::.:|:
Frog   768 DGY-----CPDLE-----LSDSEAESDENKDHMLLRRNSRESPNRDSCRNSRIRGKRKMTSHSSV 822

Fly 772 771
Frog 823 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	22/45 (49%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	47/116 (41%)
jade3	XP_012812727.1	COG5141	<172..543	CDD:227470	104/382 (27%)
		PHD_JADE3	211..260	CDD:277151	23/52 (44%)
		ePHD_JADE3	264..374	CDD:277176	47/116 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940