DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and Kdm4c

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001165566.1	Gene:	Kdm4c / 76804	MGIID:	1924054	Length:	1071	Species:	Mus musculus

Alignment Length:	277	Identity:	90/277 - (32%)
Similarity:	133/277 - (48%)	Gaps:	43/277 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DSSKD--DTIHSTSLNKKLVKIKKFKLDDMKEMVGGCCVCSDER--GWPENPLVYCDGQN----- 82
            ||||:  |:...|::|:.:...:|.| ..:.||   |.:.|:|.  ..|.|..:..||.:
Mouse   673 DSSKEENDSRWETAVNEVVQSGRKTK-PIIPEM---CFIYSEENVDYSPPNAFLEEDGTSLLISC 733

  Fly    83 --CTVAVHQACYGIVT--VPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCAL 143
              |.|.||.:|||:.:  |..| |.|.:|:....|:  .|.||..|.||||:|.|:.||||:||:
Mouse   734 AKCFVRVHASCYGVPSHEVCDG-WLCARCKRNAWTA--ECCLCNLRGGALKQTKNNQWAHVICAV 795

  Fly   144 YIPEVRFGNVTTMEPIILSLIPQERYSKTCYICQ-EIGKPNRANVGACMQCNKSNCKQQFHVTCA 207
            .:|||||.||.....|.:..||.:|....|..|: .:.|.:    |||:||:...|...||||||
Mouse   796 AVPEVRFTNVPERTQIDVDRIPLQRLKLKCIFCRHRVKKVS----GACIQCSYGRCPASFHVTCA 856

  Fly   208 QSLGLLCE-EAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQHDTSSDSCSSPEKEIDST 271
            .:.|:|.| :...|:.|:.    |..|    :...|.|:         .|...:.|..:..|...
Mouse   857 HAAGVLMEPDDWPYVVNIT----CFRH----RVNSNAKS---------KTCEKAISVGQTVITKH 904

  Fly   272 MNSATTSATIIKITSSS 288
            .|:...|..:|.:||.:
Mouse   905 RNTRYYSCRVIDVTSQT 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	18/57 (32%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	48/116 (41%)
Kdm4c	NP_001165566.1	JmjN	33..74	CDD:301729
		JmjC	194..310	CDD:202224
		PHD_SF	660..761	CDD:304600	29/92 (32%)
		PHD_SF	770..879	CDD:304600	48/116 (41%)
		TUDOR	892..948	CDD:197660	7/30 (23%)
		TUDOR	950..1005	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910