DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and brd1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001073031.1	Gene:	brd1 / 733743	XenbaseID:	XB-GENE-949377	Length:	1185	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	108/327 - (33%)
Similarity:	155/327 - (47%)	Gaps:	69/327 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NKIPSSFNAKLELDSSKDDTIHSTSLNKKLVK---------IKKFKLD--------------DMK 55
            :|.|...:.::|.|..::|......:|:|...         |.:|.:|              |.:
Frog   144 DKSPEELDKEVEYDMDEEDYAWLEIINEKRKSEGFSAVSQDIFEFLMDRFEKESYCENQKQGDQQ 208

  Fly    56 EMV---GGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVR 117
            .::   ..||:|.|......|.:::||  .|.:||||.|||:..:|.|.|.||.| .|.|...:.
Frog   209 SLIDEDAVCCICMDGECQNSNVILFCD--MCNLAVHQECYGVPYIPEGQWLCRHC-LQSRNIPID 270

  Fly   118 CELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGK 181
            |.|||::.||.||||:..|.||||||:||||.|.|...:|||. :..||..|:..|||:|::.|
Frog   271 CVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG- 334

  Fly   182 PNRANVGACMQCNKSNCKQQFHVTCAQSLGL------LCEEAGNYLD-NVKYCGYCQHHYSKLKK 239
                 ||||:||:|:||...|||||||..||      :.|.||:... :||...||..|
Frog   335 -----VGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKEVAGSITTFSVKKTAYCDAH------ 388

  Fly   240 GGNVKTIPP---YKPI----QHDTSSDSC-SSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSN 296
                  .||   .:|:    :.::.:..| .|.:|.|.||..:..      |.|.:......:.|
Frog   389 ------TPPGCVRRPLNIYEEPESKNGICRKSSDKNIRSTSKARR------KTTKAKKELNETCN 441

  Fly   297 VL 298
            ||
Frog   442 VL 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/46 (43%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	59/122 (48%)
brd1	NP_001073031.1	EPL1	47..196	CDD:371106	10/51 (20%)
		COG5141	139..>571	CDD:227470	108/327 (33%)
		Bromo_brd1_like	565..662	CDD:99944
		BR140_related	1054..1169	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950