Protein Alignment Alh and brd1a

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_698063.6
• Gene: brd1a / 569574
• ZFINID: ZDB-GENE-041008-168
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1002
• Identity: 207/1002 - (20%)
• Similarity: 332/1002 - (33%)
• Gaps: 316/1002 - (31%)

  Fly     3 ERNNNKQVTSSNKI-----------------------PSSF-----------NAKLELDSSKDDT 33
            :.||.|:.||.:.|                       ||::           :.::|.|..::|.
Zfish    81 KNNNQKKNTSDSSIQGSILPEPKFHTVDYNLPVIPSRPSTYYKYEQKTVEELDQEVEYDMDEEDF 145

  Fly    34 IHSTSLNKK-------LVK-------IKKFKLDDMKEMVGG------------CCVCSDERGWPE 72
            .....:|:|       ||.       :.:|:.:...|..|.            ||:|.|......
Zfish   146 AWLDLVNEKRKDEGLNLVSFDDFEFLLDRFEKESFLESQGQHTLQSIDDEDAVCCICMDGDCMDS 210

  Fly    73 NPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWA 137
            |.:::||  .|.:||||.|||:..:|.|.|.||.| ....|....|.|||::.||:|:|::..|.
Zfish   211 NVILFCD--MCNLAVHQDCYGVPYIPEGQWLCRHC-LHSPTQPANCILCPNKGGAVKQTEDDRWG 272

  Fly   138 HVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQ 201
            ||||||::|||.|.|...:|||. :|.||..|:..|||:|:|.|      ||||:||:|:||...
Zfish   273 HVVCALWVPEVGFSNTVFIEPIDGVSNIPPARWKLTCYLCKEKG------VGACIQCHKANCYTA 331

  Fly   202 FHVTCAQSLGLLCE--------EAGNYLDNVKYCGYCQHHYSKLKKGGNVK-TIPPYKPIQHDTS 257
            |||:|||..||..:        ::|....:||...||..|    ...|:|| .:..||  .::|:
Zfish   332 FHVSCAQKSGLFMKMEPIKVLTDSGIPTFSVKKTAYCGAH----TPNGSVKRPLAIYK--DNETN 390

  Fly   258 SDSCS-----------SPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSS 311
            ...|.           :.:|.:.....:..|  ||..::..|.|:...|.:||..|
Zfish   391 YGLCQLVDRKSSRIGFNKQKRLKKNEEAIVT--TIPPLSVPSFSSERLSPILNQVS--------- 444

  Fly   312 SGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAP---------NPSSSSVHSGSASNMTG--- 364
                      .:|..|..:...|..:....|..|.|         :|..:|....:......
Zfish   445 ----------LQKKTAFGELVLSYWTLKRQSRNGVPLNRRLQTRLHPPKNSQRKQTEEETQALKE 499

  Fly   365 --------------------------------------------------------------GGS 367
                                                                          ...
Zfish   500 QLKEWHQLRHDLERARILLELIRKREKLKREEVLLQQTLMEFQLTPFTVILRAVLDQLQEKDQAH 564

  Fly   368 VLPGSSNIGNISNSLNNNL-PGGSSSTSSAGNVPG------------------------------ 401
            :.....||..:.:.:::.| |...|:.|......|
Zfish   565 IFAEPVNIKEVPDYMDHVLHPMDFSTMSKRIEAQGYKYLDEFEADFNLITDNCMKYNGKDTFFYR 629

  Fly   402 ------GSGGIISASSGGATQSTSSQSSTA-----PGTTKSSASSS-----------SSSSNSYK 444
                  ..||.|...:....|.......|.     |...:.|...|           :....|::
Zfish   630 AAVKLRDQGGAILRKTRRDVQRIGLDLETGLHLLEPPKIEPSVPFSWEDVDRLLVPANREHMSFE 694

  Fly   445 EKHSKSLSK---STSSKDKDGKDSSTNSANNNFT------NSSASSTSSNSSSTREKSSSKLSKN 500
            |:..:.|.|   :|:.|....:.........|.:      :...:.|:....:..|:....:.:.
Zfish   695 EQLRELLEKLDMTTAMKSSPSRSRRLKLLKKNISDVRLELSLRKALTAVKLKNAAEEEVGHIHQK 759

  Fly   501 KDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHT 565
            .|.:..|....|:|....||.:..|...|                   |.......::||:....
Zfish   760 GDKSVPPKLEPSVSVLPLINAESHSEPPT-------------------LKPIEPNPDKHSHQKDG 805

  Fly   566 LSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSS----SSTVNDSTGGFGSNSNSERENL 626
            :|.:          |...|:|....    ||:..|:||:    ||.||..|......|.|....|
Zfish   806 ISQS----------LNGDSHLLLED----SDINVVATSTLAEPSSPVNRRTSVLFRKSKSSTSPL 856

  Fly   627 SGAGSSASNMPGTIAPGTGGVSSSAATNLST-------NKGGSSSSTANSL------TSTSTSSG 678
            ... .....:.|:...||....|.....|.|       .:..|..|..:.|      |..|.|.|
Zfish   857 RTL-KDDETLKGSSQIGTKTFLSVVIPRLETLLHTRKRPRSASGDSCKDELPIKRLDTELSNSFG 920

  Fly   679 SSS----NSSSKKRKADSAKSTSSISTSGSAL------EDNNSLISRYDIKDVQ--VALTPLTDF 731
            .||    :|||:.|:..:::|:.|.|.|..||      :...:||.|..::|..  :|.....:|
Zfish   921 LSSERELSSSSQPRQRCTSESSMSSSNSSIALNLMKCGKGKPALIRRNTVEDKSEIIACIESRNF 985

  Fly   732 EKEIEKSSKRQRTELSPPTHQTSATAE 758
            .|....:::...:.:..|::..:...|
Zfish   986 AKAARIAAEVNSSSIWMPSNAATVLLE 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/58 (34%)
		ePHD_AF10_like	118..233	CDD:277142	55/123 (45%)
		CC_AF10	1636..1699	CDD:411015
brd1a	XP_698063.6	None