DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and kdm4b

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001076274.1	Gene:	kdm4b / 556504	ZFINID:	ZDB-GENE-060503-664	Length:	1134	Species:	Danio rerio

Alignment Length:	260	Identity:	79/260 - (30%)
Similarity:	113/260 - (43%)	Gaps:	52/260 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LVYCDGQNCTVAVHQACYGI--VTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWA 137
            |:.|.|  |.:.||.:|||:  .|...| |.|.:|.:...|:  .|.||..|.||||||.:..|.
Zfish   743 LLSCSG--CNLQVHASCYGVNPQTKQEG-WMCSRCTTVAWTA--ACCLCSLRGGALKKTTDERWV 802

  Fly   138 HVVCALYIPEVRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQF 202
            ||:||:.:.||||.|....||:.::.:|:.|.|..|..|.   |..:...|||:||::.||...|
Zfish   803 HVICAIAVAEVRFVNAIEREPVDVTAVPETRKSLKCVYCH---KTTKQIFGACIQCSQDNCSTSF 864

  Fly   203 HVTCAQSLGLLCEEAG-NYLDNVKYCGYCQHH---YSKLKKGGNVKTI----------------- 246
            |||||...|::.:.|. .|:.:|.    |..|   ..|.|.|....::
Zfish   865 HVTCALLAGVVMKPADWPYVVSVT----CHKHKLTNQKAKSGSRDLSLGQEVIGRNSNGWFYRCV 925

  Fly   247 ------PPYKPIQHDTSSDSCSS--PEKEI--DSTMNSATTSATIIKITSSSGSAGGSSNVLNAS 301
                  ..|..:..|..| .|.:  ||..:  |...|.......::.:.:..|      .|||||
Zfish   926 ITGTGTQTYYEVNFDDGS-YCDNIFPENLLSHDCLRNGPPELGELVVVKTVDG------RVLNAS 983

Fly 302 301
Zfish 984 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	13/33 (39%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	46/115 (40%)
kdm4b	NP_001076274.1	JmjN	95..136	CDD:128818
		JmjC	256..372	CDD:202224
		YscO	<408..512	CDD:284686
		PHD_JMJD2B	676..774	CDD:277051	13/33 (39%)
		PHD_SF	783..892	CDD:304600	46/115 (40%)
		TUDOR	905..953	CDD:197660	6/48 (13%)
		tatB	<978..1099	CDD:166942	5/6 (83%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910