Protein Alignment Alh and mllt10

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_017209395.2
• Gene: mllt10 / 492342
• ZFINID: ZDB-GENE-041114-176
• Length: 1162
• Species: Danio rerio
• Alignment Length: 1322
• Identity: 386/1322 - (29%)
• Similarity: 540/1322 - (40%)
• Gaps: 346/1322 - (26%)

  Fly     1 MCERNNNKQVTSSNKIPSSFNAKLELDSS------KDDTIHSTSLNKKLVKIKKFKLDDMKEMVG 59
            ||...:.:.|:|......|:..:.|:.||      :||...|                :||||:|
Zfish     1 MCAYFSQRIVSSKFDEEDSYFRECEMVSSELYLAEEDDDSPS----------------NMKEMIG 49

  Fly    60 GCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSR--------- 115
            |||||||||||.|||||||||..|.|||||||||||.||||||:|||||||||.:|
Zfish    50 GCCVCSDERGWAENPLVYCDGHGCNVAVHQACYGIVQVPTGPWFCRKCESQERAARVIKGWRGRK 114

  Fly   116 ---------------------------------VRCELCPSRDGALKKTDNSGWAHVVCALYIPE 147
                                             |||||||.:|||||:|||.|||||||||||||
Zfish   115 PSWQTPEGGGQSTTCNKEEEDSRLSRSLKTLNIVRCELCPQKDGALKRTDNGGWAHVVCALYIPE 179

  Fly   148 VRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGL 212
            |.|.||:|||||:|..:|.|||:||||||:|.|:.::|..||||.|||..|:|.|||||||..||
Zfish   180 VEFANVSTMEPIVLQSVPHERYNKTCYICEEQGRESKAATGACMTCNKHGCRQAFHVTCAQLAGL 244

  Fly   213 LCEEAGNYLDNVKYCGYCQHHYSKLK----KGGNVKTIPPYKPIQHDTSSDSCSSPEKEID---- 269
            ||||.|:..|||||||||::||:||:    :|...:::........|...|......||.|
Zfish   245 LCEEQGSDADNVKYCGYCKYHYNKLRRSKGRGSRAQSLSDSSTHSLDKHHDKEKKKHKERDRHKP 309

  Fly   270 ---------------------STMNSATTSATIIKITSS------SGSAGGSSN---VLNASSSA 304
                                 .:.|::::..::..|:|:      ||:...::|   |...|||:
Zfish   310 KHKKPLELSPSLVPALMVTPEKSYNNSSSGGSVSSISSTQKRLDDSGARFTNANFQEVPPHSSSS 374

  Fly   305 GISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPN------------PSSSS---- 353
            ....|||.|.  ||.:|.:||  |..:||||.|....|..|.|:            |||:|
Zfish   375 SKDGGSSDGK--SSDSKSKKS--SHSTSSSSGSRGRKSVAGKPHGPVVTTATSSTAPSSTSPFQQ 435

  Fly   354 ---VHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGAT 415
               :.|.|:|.....|||:..:|:..:.|:.   :|..|.|.|      |...|   .....|..
Zfish   436 GHLLGSNSSSKSATSGSVVQPTSDFLSFSDP---SLRAGDSYT------PPSFG---RCHMKGGA 488

  Fly   416 QSTSSQSSTAPGTTKS---SASSSSSSSNSYKEKHSK-SLSKSTSSKDKDGKDSSTNSANNNFTN 476
            :|.:|:|..|..|...   |.|||||||..|:..|:. .|....|:..|..:.||::|
Zfish   489 ESGASESMVALNTFSMIPLSQSSSSSSSKHYENCHTTGELGSLASASYKRPQPSSSSS------- 546

  Fly   477 SSASSTSSNSSSTREKS------------SSKLSKNKDSNQ----VPSATS-SLSTTSSINTQPS 524
            |:.||:|:.....::|.            :::.||..|:.:    :||:|| |.|:.|::..:.|
Zfish   547 SATSSSSTGEDGVKKKKRGNWRNRYGPCFTTQDSKTTDAGEHISTMPSSTSPSPSSMSNMVCRGS 611

  Fly   525 SSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSN---- 585
            :.:|||:.|:.|.||     ::.|:..:||.....|....|:|:.....|.......|.|:
Zfish   612 TVSSTASVGAVGAGT-----SSLGIQKSPSLLRNGSLQGMTVSSPPAVPGEQKRSYPSSSDVACP 671

  Fly   586 -----LSNSSSGFGSDL---RSVSTSSSSTVND--STGGFGSNSNSERENLSGAGSSA------- 633
                 |..|.|...|:|   :||..:|..|:..  |...|.|..::...:|.|:.:.|
Zfish   672 LPSAVLGGSMSASNSELPAHQSVVVTSMPTLTSLPSAAPFTSTPSTHANSLPGSFNLAPSHMFGN 736

  Fly   634 -----SNMPGTIAPGTGGVSSSAATN--LSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKAD 691
                 |.|...||...|..:.....:  |..::.|:|..|  :|:..|..||......:......
Zfish   737 RLNPNSAMAALIAQSEGSPADQELGDGALGFSRRGNSPKT--NLSPRSPLSGLHIRYDAGPMVPG 799

  Fly   692 SAKSTSSISTSGSAL---------EDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELS 747
            ....:.::..:.:::         |....|:.:....||...|..|...:.|..:..::.||...
Zfish   800 LGSGSDTLPPAATSIDQLLERQWNEGQQFLLQQGSQGDVLAMLKSLHQLQVENRRLEEQIRTLTM 864

  Fly   748 PPTHQTSATAEVNAPLASSTSASIAVTASATAASAP--PATGTTTLGSSISGNAGSTSSGNSSGV 810
            ........:|:::.|.   |.||    .:||.||:|  |:...|.:..|.|...||.
Zfish   865 KKERLQLLSAQLSVPF---TPAS----TTATTASSPMYPSNTHTDMLHSKSIQLGSV-------- 914

  Fly   811 SATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSNQQASTASSS 875
                            .||||:...|....||..||.                     :||:|.|
Zfish   915 ----------------LTESSQPLPTQDPQSGGHSSG---------------------SSTSSLS 942

  Fly   876 SAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGP--PMGG 938
            :.||...|.|....|  |:.:..........:.|..|.:..:|        |..||.|.  .|.|
Zfish   943 TPPSAAHSPPQQQVN--GVGMAGVPVQPGNANSSLPAIAGVTG--------LMGALQGNHLAMSG 997

  Fly   939 SAGAFHGGTTSAGSSSVIQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLK 1003
            ..||.: |......||:.|..|                         |||.    :.|..|.:|.
Zfish   998 IVGALN-GVIQTSQSSLTQNSS-------------------------PLPQ----SATASSASLS 1032

  Fly  1004 IS-----YEKQTTRVQQLQEQEAPPARRSRSRSGESGSSHHHAHAHHHH-------HHPTHHNSH 1056
            :|     ....||:.:...||                  |.....|.|.       ..||.....
Zfish  1033 MSSSLTNSSMSTTKTRLFTEQ------------------HRQILLHQHQLQQLFGSQQPTPEQQQ 1079

  Fly  1057 --HQQNPQQQQQLHQQQQQNASSHMHACTNSSSSTSTSTTSSSLSGGTAPATSSSNSKGPSRSGK 1119
              ..|..|||||..||||||.........||....:..|||      |.|..:..|.....::|.
Zfish  1080 VLLYQLMQQQQQQQQQQQQNDIQFQQLPINSLLPGNQPTTS------TNPFLAHHNDNNTPKAGV 1138

  Fly  1120 KRGAAMNKSESTSVATTATPAT 1141
            ...|.   .::..:...|.|.|
Zfish  1139 NTAAI---KQTKRLGEKAVPVT 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	40/46 (87%)
		ePHD_AF10_like	118..233	CDD:277142	81/114 (71%)
		CC_AF10	1636..1699	CDD:411015
mllt10	XP_017209395.2	PHD_AF10_AF17	50..97	CDD:277049	40/46 (87%)
		ePHD_AF10	148..273	CDD:277178	87/124 (70%)
		CC_AF10	813..876	CDD:411015	10/62 (16%)