DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and kdm4b

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_989064.2	Gene:	kdm4b / 394661	XenbaseID:	XB-GENE-1012886	Length:	1025	Species:	Xenopus tropicalis

Alignment Length:	258	Identity:	76/258 - (29%)
Similarity:	109/258 - (42%)	Gaps:	56/258 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 STSLNKKLVKIKKFKLDDMKEMVGGCCVCSDERGWPENPL---VYC--DGQN-------CTVAVH 88
            |..|::.::...| |....|.::...|..:.  |...:||   .|.  ||.:       |.:.||
Frog   638 SACLSEYMIPSSK-KGQKTKALIPEMCFAAS--GGNTDPLPVSTYTLEDGTSILLSCAKCCLQVH 699

  Fly    89 QACYGIVTVPTGP------WYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPE 147
            .:|||:     .|      |.|.:|.:  ......|.||..|.|||..|.:..|.|:|||:.:||
Frog   700 ASCYGV-----NPDLVEDNWTCSRCTA--CAWNADCCLCNLRGGALHITTDKRWVHIVCAVVVPE 757

  Fly   148 VRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGL 212
            .||.|.....|:.:..||::|....|..|:   :..|..||||:||:...|...||||||.:.|:
Frog   758 ARFINPVERHPVDVRTIPEQRCKLKCVYCR---RKIRKEVGACVQCSVDRCSTSFHVTCAYTAGI 819

  Fly   213 LCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQHDTSSDSCS-SPEKEIDSTMNS 274
            ..|.     |:..|                |.:|..:|   |..|:.|.| |.|..|..|:.|
Frog   820 TMEP-----DDWPY----------------VVSITCFK---HGASNQSSSFSREVSIGQTVIS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	16/64 (25%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	42/114 (37%)
kdm4b	NP_989064.2	JmjN	14..55	CDD:128818
		JmjC	175..291	CDD:396791
		PHD_JMJD2B	624..719	CDD:277051	21/88 (24%)
		ePHD_JMJD2B	728..837	CDD:277184	45/135 (33%)
		Tudor_JMJD2B_rpt1	850..903	CDD:410535	3/9 (33%)
		Tudor_JMJD2B_rpt2	907..962	CDD:410538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910