Protein Alignment Alh and Jade3

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001393168.1
• Gene: Jade3 / 382207
• MGIID: 2148019
• Length: 850
• Species: Mus musculus
• Alignment Length: 697
• Identity: 163/697 - (23%)
• Similarity: 233/697 - (33%)
• Gaps: 241/697 - (34%)

  Fly    34 IHSTSLNKKLVKIKKFKLDDMK---EMVGG----------CCVCSDERGWPENPLVYCDGQNCTV 85
            |..|.:.|.:..:::...::|.   |.|.|          |.||........|.:|:||  .|.|
Mouse   190 IDETLMEKTIEVLERHCHENMNHAIETVEGLGIEYDEDVICDVCRSPDSEEGNDMVFCD--KCNV 252

  Fly    86 AVHQACYGIVTVPTGPWYCRKCESQERTSRV-----RCELCPSRDGALKKT-DNSGWAHVVCALY 144
            .||||||||:.:|.|.|.||.|        |     :|.|||.:.||:|.| ..:.||||.|||:
Mouse   253 CVHQACYGILKIPEGSWLCRSC--------VLGIYPQCVLCPKKGGAMKTTRTGTKWAHVSCALW 309

  Fly   145 IPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQ 208
            ||||.......|||:. :|.||..|::..|.:|       :...|||:||:..:|...||||||.
Mouse   310 IPEVSIACPERMEPVTKISHIPPSRWALVCNLC-------KLKTGACIQCSVKSCITAFHVTCAF 367

  Fly   209 SLGLLCEEAGNYLDNVKYCGYC---------------QHH------------------------- 233
            ..||..:...:..|.||:..:|               .||
Mouse   368 EHGLEMKTILDEGDEVKFKSFCLKHSQNKPKLGDAEYHHHRVAEQSQAKSEKTSLRAQKLRELEE 432

  Fly   234 ---------------------------YSKLKKGGNVKTIPPYKPIQHDTSSDSCSSPEKEIDST 271
                                       |.|||:..|..  .|..|.:.:..:......|:.|.:.
Mouse   433 EFYTLVQVEDVAKEMELSAFTVDFIYNYWKLKRKSNFN--KPLIPPKEEEENGLVQPKEESIHTR 495

  Fly   272 M---------------------------------------------NSATTSATII--------- 282
            |                                             |...|....:
Mouse   496 MRMFMHLRQDLERVRNLCYMISRREKLKLSHTKVQEQIFGLQVQLINEEITEGLSLTNALENSLF 560

  Fly   283 ----KIT-------SSSGSAGGSSNVLNASSSAGISAGSSSGSGVSSSAKQ-------------- 322
                :||       |:|.....||    ..:...:|:..||..|.|..:.|
Mouse   561 YPPPRITLKLKMPKSTSEDCKDSS----TETEHQLSSPGSSSPGHSKRSPQMPEEPLDMNVKIYP 621

  Fly   323 -----RKSNA--SSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISN 380
                 .|||.  :|:|.|...:.|||.|..|  ||:...|..|........:.|.|..:|||..|
Mouse   622 RYPLESKSNCLQTSRSHSRCETKSSSPTPRA--PSAEFYHGQSLGKPLALQAALHGQVSIGNGKN 684

  Fly   381 SLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQ----------SSTAPGTTKSSASS 435
            ..|:.:   |||....||           .||..||..:|.          ||..|.......||
Mouse   685 QPNSRV---SSSNGLEGN-----------WSGNITQKVNSSEVCYDQESMLSSHLPSPGNIRKSS 735

  Fly   436 SSSSSNSYKE------KHSKSL------SKSTSSKDK-DGKD---SSTNSANNNFTNS---SASS 481
            ....|.|:||      |.::.|      :|:.|||:: .|:.   ..|..|:...|:.   ....
Mouse   736 MEHFSRSFKEATNTWVKPTEDLQYCVKPTKNVSSKEQLWGRQLLRRPTGRASYQETDGYCPDLEP 800

  Fly   482 TSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTS 528
            :.|.:.....|.:.::.:.....:.||..|:........|.|.|.:|
Mouse   801 SDSEAEGEGSKETPRVKRESSDRENPSHDSARECHGKTKTHPHSHSS 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/56 (41%)
		ePHD_AF10_like	118..233	CDD:277142	46/131 (35%)
		CC_AF10	1636..1699	CDD:411015
Jade3	NP_001393168.1	EPL1	<74..204	CDD:463128	3/13 (23%)
		COG5141	165..>536	CDD:227470	89/364 (24%)
		PHD_SF	282..392	CDD:473978	46/116 (40%)