DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and Mllt10

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_038951869.1	Gene:	Mllt10 / 361285	RGDID:	1310874	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	1156	Identity:	355/1156 - (30%)
Similarity:	480/1156 - (41%)	Gaps:	320/1156 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SSKDDTIHSTSLNKKLVKIKKFKLDDMKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACY 92
            |.:|:..||                 ||||:||||||||||||.|||||||||..|:||||||||
  Rat     9 SLEDEVSHS-----------------MKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACY 56

  Fly    93 GIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTME 157
            |||.||||||:|||||||||.:||||||||.:|||||:|||.||||||||||||||:|.||:|||
  Rat    57 GIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTME 121

  Fly   158 PIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLD 222
            ||:|..:|.:||:||||||.|.|:.::|..||||.|||..|:|.|||||||..||||||.||..|
  Rat   122 PIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGAD 186

  Fly   223 NVKYCGYCQHHYSKLKK---GGNVKTIPPYKPIQHDTS-SDSCSSPE-----------KEID--- 269
            ||:|||||::|:|||||   |.|         ..:|.| |||.|..:           ||.|
  Rat   187 NVQYCGYCKYHFSKLKKSKRGSN---------RSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHK 242

  Fly   270 -----------STMNSATTSATIIKITSSSGSAGGSSNVLNASSS-------AGISAGSSSGSGV 316
                       :.:.|.|.:......::|:.|..||...|..:::       ..:||.:|||..|
  Rat   243 PKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDV 307

  Fly   317 SSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNP-----SSSSVHSGSASNMTG------GGSVLP 370
            |.:   |......|||:.||.......||..||     :||....||.|...|      |.||..
  Rat   308 SEA---RSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSASSPFPQGSFSGTPGSVKSSSGSSVQS 369

  Fly   371 GSSNIGNISNSLNNNL-----------------PG----GSSSTSSAGNVPGGSGGIISASSGGA 414
            ....:....:.|.|:.                 ||    |.:|.||....||        :||..
  Rat   370 PQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNSFSSLVGHPG--------TSGAT 426

  Fly   415 TQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSST----------NS 469
            :|..|..||  ||    ...|||..:..||...:..:.:..:.|:|..|.:..          |.
  Rat   427 SQPKSFDSS--PG----ELGSSSLPTAGYKRAQTSGVEEEEAVKEKKRKGNKQSKHGPGRPKGNK 485

  Fly   470 ANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQP----SSSTSTA 530
            ...|.::.|.||.|..||                  |.||..|: |:.|:...|    :.|..:.
  Rat   486 NQENVSHLSVSSASPTSS------------------VASAAGSV-TSCSLQKSPTLLRNGSMQSL 531

  Fly   531 TAGSGGTGTHVSSSAASGLNSAPSTT-NEHSNHAH---------TLSTNGTGAGSAAGKLQSVSN 585
            :.||...|:.:|...... .:.|:|| :|..|..|         .:|.....:||.:....|.|:
  Rat   532 SVGSSPLGSEISMQYRHD-GACPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSGSSTPVSSSH 595

  Fly   586 LSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSS 650
            :...|||....:.::|.|::|:|..:.....:|        :..|||.|..|..:.......:.|
  Rat   596 IPQQSSGHLQQVGALSPSAASSVTPAAATTQAN--------TAPGSSLSQAPAHVYGSRLNQNPS 652

  Fly   651 AATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSALE-------D 708
            .|..::.::...:.......|.:....|||...|...|...|.........|.|.||       .
  Rat   653 MAVLIAQSESSQTDQDLGDNTRSLVGRGSSPRGSLSPRSPVSNLQIRYDQPSSSGLESLPPVAVS 717

  Fly   709 NNSLISRY---------------DIKDVQVALTPLTDFEKEIEK-----SSKRQRTEL------- 746
            ...|:.|.               ||..:..:|..|....:.:|:     ::|::|.:|
  Rat   718 IEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSV 782

  Fly   747 -------SP-PTHQ----TSATAEVNAPLASSTSASIA---------------------VTASAT 778
                   :| |:||    |:.||.....|.||.|..|.                     .|:|::
  Rat   783 PFPAITTNPSPSHQIHTYTAQTAPTTDSLNSSKSPHIGNSFVPDNSLPVLNQDLTSSGQSTSSSS 847

  Fly   779 AASAPPATGTTTL--GSSISG-------NAGSTSSGNSSGVSATGGAQSAVGS--GGYPKTESSK 832
            |.|.||..|.:..  ||.:||       ..|..:||..: |::|..|.||||.  |..|..:.:
  Rat   848 ALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGPLASGMQT-VTSTIPAVSAVGGIIGALPGNQLA- 910

  Fly   833 SSGTASAGSGSGSSSNTSSTKHGSNIKDISSSSN---QQASTASSSSAPSLYVSVPLSTAN-VPG 893
                                     |..|..:.|   |...|.|.:.||..:.|||.:.|: :|.
  Rat   911 -------------------------INGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPA 950

  Fly   894 INLPTSST------------------------SSSTTSESHSASSRSSGAQSQH-----QQQL-- 927
            ..|..|::                        |...|.|.|.|.......|..|     |.||
  Rat   951 AALTNSASGLGLLSDQQRQMFLQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQMQLPG 1015

  Fly   928 ------SNALVGPPMGGSAGAFHGGTTSA-------GSSSVIQQQSGKSSP 965
                  :|.|.|||    |...|..||:.       .:|..:.:.|.|:.|
  Rat  1016 PTQIPINNLLAGPP----APPLHTATTNPFLTIHGDSTSQKVTRLSDKTGP 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	40/46 (87%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	80/114 (70%)
Mllt10	XP_038951869.1	PHD_AF10_AF17	24..71	CDD:277049	40/46 (87%)
		ePHD_AF10	78..206	CDD:277178	89/127 (70%)
		CC_AF10	717..780	CDD:411015	10/62 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3066
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4291
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004366
OrthoInspector	1	1.000	-	-		oto95874
orthoMCL	1	0.900	-	-		OOG6_105638
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3088
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.050