DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and jade1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_956099.1	Gene:	jade1 / 327437	ZFINID:	ZDB-GENE-030131-5648	Length:	829	Species:	Danio rerio

Alignment Length:	687	Identity:	164/687 - (23%)
Similarity:	252/687 - (36%)	Gaps:	200/687 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            |.||....|...|.:|:||  .|.:.||||||||:.||.|.|.||.|   ......:|.|||.:.
Zfish   199 CDVCQSPDGEDGNEMVFCD--KCNICVHQACYGILKVPEGSWLCRTC---ALGIFPKCHLCPKKG 258

  Fly   126 GALKKTDNSG--WAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANV 187
            ||:|.| .||  |.||.|||:||||..||...||||. :|.||..|::..|.:|:|       ..
Zfish   259 GAMKPT-RSGTKWVHVSCALWIPEVSIGNPEKMEPITNVSHIPSNRWALICCLCKE-------KT 315

  Fly   188 GACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKL----KKGGNVKTIPP 248
            |||:||:..:|:..|||||....||.........|.||:..:|..| |.|    ::|.:.:  |.
Zfish   316 GACIQCSAKSCRVAFHVTCGLHCGLKMNTILTEADEVKFKSFCPKH-SGLDWNEEEGDDDR--PV 377

  Fly   249 YKPIQHDTSSD-----SCSS--------------------------------------------- 263
            ..|.:.|.|.:     |.||
Zfish   378 KVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSERKLRVQQLEDEFYRFVAADEVAEHLQLPLE 442

  Fly   264 -----------------------PEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAG 305
                                   |:||.:.::........:.::...:........|.|.:....
Zfish   443 MVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARREQEVLLRRLRLFTHLRQDLERVRNLTYMVS 507

  Fly   306 -----------------------ISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAP 347
                                   :..|..  :||||:.:..::....:::....:|        |
Zfish   508 RRERIKRTLCRVQEQIFHHHVRLLEQGRV--TGVSSTRRLEEAMFYFRTTPPVPAS--------P 562

  Fly   348 NPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSG 412
            .|...  |.|..|.::        ||..|:.|...:.::.....:......||         |||
Zfish   563 QPLKG--HCGQNSTLS--------SSEKGSNSYRSSKHIEADKPAKMLMDGVP---------SSG 608

  Fly   413 GATQS---TSSQSSTAPGTTKSSASSSSSSSN-----------------SYKEK--HSKSLSKST 455
            .:.:|   .|:.|..:.|.|:|..|......:                 |.|:|  |:||:..:.
Zfish   609 DSVRSETVMSASSRRSEGRTRSGESHRKEEESERPLEDRRRKSKLWDQVSIKDKLRHAKSMEDTL 673

  Fly   456 SSK-DKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATS-------- 511
            ||: :.|..|.....::.| .||.|::.:..|.|.|:.::|...|     .||:.||
Zfish   674 SSETELDTMDDRLLLSHTN-ANSVATAPNMYSGSPRKTNASHQGK-----LVPNGTSGRHLKNWG 732

  Fly   512 -------SLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTN 569
                   |..|::...|:...:.:||...| ...|..:|.::..:.:...|.:|:..|   |..:
Zfish   733 SFRIPKRSERTSAGRQTERQEADNTADQNS-SLKTFSTSPSSPQIRTRLRTGSENRRH---LEES 793

  Fly   570 GTGAGSAAGKLQSVSNL-SNSSSGFGSDL--RSVSTS 603
            ..|. |..||......| |..:..:|||:  |.|..|
Zfish   794 DLGQ-SEQGKRCHTQRLPSPMTRRYGSDVIQRGVLAS 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/45 (51%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	50/117 (43%)
jade1	NP_956099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		EPL1	<104..173	CDD:287484
		PHD_JADE1	198..243	CDD:277149	23/45 (51%)
		ePHD_JADE	251..361	CDD:277141	50/117 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..408		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..651		22/121 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..829		33/141 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592485
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.870