DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and jade3

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_970614.2	Gene:	jade3 / 322209	ZFINID:	ZDB-GENE-030131-928	Length:	795	Species:	Danio rerio

Alignment Length:	647	Identity:	164/647 - (25%)
Similarity:	233/647 - (36%)	Gaps:	139/647 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRV-----RCEL 120
            |.||........|.:|:||  .|.:.|||||||||.||.|.|.||.|        |     :|.|
Zfish   204 CDVCRSPDSEEGNDMVFCD--KCNICVHQACYGIVKVPDGNWLCRTC--------VLGITPQCLL 258

  Fly   121 CPSRDGALKKT-DNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPN 183
            ||...||:|.| ..:.||||.|||:||||.......||||. :|.||..|:|..|.:|
Zfish   259 CPKTGGAMKATRAGTKWAHVSCALWIPEVSIACPERMEPITKVSHIPPSRWSLICSLC------- 316

  Fly   184 RANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPP 248
            :...|||:||:..||...||||||....|..:...:..|.||:..||..| ||.|.|.     |.
Zfish   317 KLKTGACIQCSVKNCTIPFHVTCAFEHSLEMKTILDEGDEVKFKSYCLKH-SKPKAGE-----PG 375

  Fly   249 YKPIQH--DTSSDSCS-------SPEKEIDSTMNSATTSATI---------------IKITSSSG 289
            ..|.:|  .|.:|..|       ..|:|..:.::....:..:               :|..|:..
Zfish   376 LSPARHKPPTETDKLSLRAQKLQELEEEFYTYVHPEEVAHDLSLPLHLLDFIFQYWKMKRKSNFN 440

  Fly   290 SA-----GGSSNVLNASSSAGISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNP 349
            .|     ....|:|.......|.........:....::.::.....|.......|.|..    ..
Zfish   441 KALLPPKEDEENLLLQPQEDSIHTRMRMFMHLRQDLERVRNLCYMVSRREKLKLSQSKA----QE 501

  Fly   350 SSSSVHSGSASNMTGGGSVLPGSSNIGNI------SNSLNNNLP----GGSSSTSSAGNVP---- 400
            ...::|....:.....|  ||.||:|.|:      ..:|...:|    |...|:|.:||.|
Zfish   502 QIFNLHVKLVNQELSAG--LPVSSSIENLLFHPPPRITLKLKMPKVQLGNGKSSSKSGNGPLCPD 564

  Fly   401 ----------GGSG------------------GIISAS----SGGATQSTSSQSSTAPGTTKSSA 433
                      ||.|                  ||:.||    ..|.|...:.:.|..|....::.
Zfish   565 NSCNLYDTSEGGIGQGKPQLHLGRQRIEERINGILPASIYIRRDGGTPPLAVKQSGKPLALHAAL 629

  Fly   434 SSSSSSSNSYKEKHSKSLSKSTSSKDKD--GKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSK 496
            ...||:..:..|.......||....||.  .:|:|..:|:.....|..|..|..|      ...|
Zfish   630 HGQSSNGKTKNEAEKTRQIKSNGILDKPILQRDTSCLAASEKDPRSEISGKSQPS------GFHK 688

  Fly   497 LSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSN 561
            .|....|..:..||.||..|..:.|...:|..     |.|....:|:....|...|...::.:..
Zfish   689 TSLEHFSRSLKEATVSLVRTEDLRTFEKNSRK-----SSGFSKPLSTERPQGGGRASQESDGYCP 748

  Fly   562 HAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSER 623
            .|....:.    ..|.||.:......|..   |..::|.|.:..|        :||.::.:|
Zfish   749 DAELSDSE----PEAKGKCRQGGRTQNQR---GDYVKSASRAKHS--------YGSRTSVQR 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/45 (51%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	49/116 (42%)
jade3	NP_970614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		EPL1	<89..178	CDD:287484
		COG5141	139..555	CDD:227470	108/379 (28%)
		PHD_JADE3	203..252	CDD:277151	25/57 (44%)
		ePHD_JADE3	256..366	CDD:277176	49/116 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..654		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..687		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..795		17/100 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940