Protein Alignment Alh and Jade1

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_006232363.1
• Gene: Jade1 / 310352
• RGDID: 1306920
• Length: 847
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 162/677 - (23%)
• Similarity: 243/677 - (35%)
• Gaps: 185/677 - (27%)

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            |.||....|...|.:|:||  .|.:.||||||||:.||.|.|.||.|....:.   :|.|||.:.
  Rat   221 CDVCQSPDGEDGNEMVFCD--KCNICVHQACYGILKVPEGSWLCRTCALGVQP---KCLLCPKKG 280

  Fly   126 GALKKTDNSG--WAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANV 187
            ||:|.| .||  |.||.|||:||||..|:...||||. :|.||..|::..|.:|.|       ..
  Rat   281 GAMKPT-RSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNE-------KF 337

  Fly   188 GACMQCNKSNCKQQFHVTCAQSLGL-----LCEEAGNYLDNVKYCGYCQHHYSKLK--------- 238
            ||.:||:..||:..||||||...||     |.|.     |.||:..||..|.|..|
  Rat   338 GASIQCSVKNCRTAFHVTCAFDRGLEMKTILAEN-----DEVKFKSYCPKHSSHRKPEESLGEGA 397

  Fly   239 --KGGNVKTIP--PYKPI----QHDTSSDSCSSPEKEIDSTMNSATTSATIIKIT---------- 285
              :.|..:..|  |.:|.    |:...:...|..::::....:...|...::.:.
  Rat   398 AQENGATECSPQSPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVV 462

  Fly   286 -------------------------SSSGSAGGSSNVL------------------NASSSAGIS 307
                                     .....|....:||                  |.:..
  Rat   463 DFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYM---- 523

  Fly   308 AGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTG---GAPNPSSSSVHSGSASNMTGGGSVL 369
                    |:...|.::|....:....|..:.....|   |.|: |.||:.:....|....|..:
  Rat   524 --------VTRREKIKRSVCKVQEQIFSLYAKLLEQGKVSGVPS-SCSSLENMLLFNSPSVGPNV 579

  Fly   370 P----------------GSSNIGNISNSLNNNLPGGSSSTSSAG--NVPGGSGGIISASSGGATQ 416
            |                |::.:.::..|...:....||.|....  ..||.||   .....|..:
  Rat   580 PKIEDLKWHSAFFRKQMGTNLVHSLKKSHKRDALQNSSGTEGKTLLKQPGLSG---RREGSGVPE 641

  Fly   417 STSSQSST-APGTTKSSASSSSS--SSNSYKEKHSK---SLSKSTSSKDKDGKDS-----STNSA 470
            |..|...| |.....|||...:.  :.:..|.:.::   .|.|. ..|||..|.|     ||:::
  Rat   642 SLLSFEKTFAEARLISSAQQKNGVVTPDHGKRRDNRFHCDLVKG-DLKDKSFKQSHKPLRSTDTS 705

  Fly   471 NNNFTNSSASST---SSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTATA 532
            ..:..|:.|:::   ..::..||::.            ||....||   ..:.|.|:|...:
  Rat   706 QRHLDNTRAATSPGVGQSAPGTRKEI------------VPKCNGSL---VKVPTTPASPVKS--- 752

  Fly   533 GSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFG--- 594
             .||..............:.....::||:.:|      .|...|..|.:|.|.|...|...|
  Rat   753 -WGGFRIPKKGERQQQGEAHDGACHQHSDCSH------LGISRAPAKERSKSRLRTDSENDGYAP 810

  Fly   595 ----SDLRSVSTS-----SSSTVNDST 612
                ||..|.::.     :|||::..|
  Rat   811 DGEMSDSESEASEKKCIHASSTISRRT 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/45 (51%)
		ePHD_AF10_like	118..233	CDD:277142	53/122 (43%)
		CC_AF10	1636..1699	CDD:411015
Jade1	XP_006232363.1	COG5141	114..>544	CDD:227470	94/352 (27%)
		ePHD_JADE1	270..387	CDD:277174	55/132 (42%)