DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and Brpf3

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_006256191.1	Gene:	Brpf3 / 309647	RGDID:	1306868	Length:	1328	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	109/373 - (29%)
Similarity:	156/373 - (41%)	Gaps:	85/373 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KIPSSFNAKLELDSSKDDTIHSTSLNKK-------LVKIKKFKL--------DDMKEMVGG---- 60
            |.|...:|::|.|..::|......:|:|       .|....|:|        ..::....|
  Rat   272 KPPEDLDAEVEYDMDEEDMAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQS 336

  Fly    61 -------CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRC 118
                   ||||.|:.....|.:::||  .|.:||||.|||:..:|.|.|.||.| .|..:..|.|
  Rat   337 LIDEDAFCCVCLDDECHNSNVILFCD--ICNLAVHQECYGVPYIPEGQWLCRCC-LQSPSRPVDC 398

  Fly   119 ELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKP 182
            .|||::.||.|:|.:..|||||||::||||.|.|...:|||. :..||..|:..|||||::.|
  Rat   399 VLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDSIPPARWKLTCYICKQKG-- 461

  Fly   183 NRANVGACMQCNKSNCKQQFHVTCAQSLGLLCE-------EAGNYLDNVKYCGYCQHHYSKLKKG 240
                :||.:||:|.||...|||||||..||..:       .....:..|:...||:.|
  Rat   462 ----LGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAH------- 515

  Fly   241 GNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSG-SAGGSSNVLNASSSA 304
                             |.|.::..::.||       ..::.::....| ..||...    ....
  Rat   516 -----------------SPSVATARRKGDS-------PRSLSEVGDEDGLKEGGGEE----EQEE 552

  Fly   305 GISAGSSSGSGVSSSAK--QRKSNASSKSSSSSSSSSSSSTGGAPNPS 350
            |...|.....||.|..|  .:||..:||.........:    |...||
  Rat   553 GEEEGQEGQGGVGSPLKGVSKKSKMTSKQKIKKELEEA----GRETPS 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	22/57 (39%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	52/122 (43%)
Brpf3	XP_006256191.1	EPL1	177..323	CDD:287484	11/50 (22%)
		PHD_BRPF	341..394	CDD:277047	23/55 (42%)
		ePHD_BRPF3	398..515	CDD:277173	52/122 (43%)
		Bromo_brd1_like	721..818	CDD:99944
		DUF2890	909..>1004	CDD:287991
		BR140_related	1197..1312	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920