DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and Mllt6

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_038943652.1	Gene:	Mllt6 / 303504	RGDID:	1306689	Length:	1111	Species:	Rattus norvegicus

Alignment Length:	1608	Identity:	428/1608 - (26%)
Similarity:	561/1608 - (34%)	Gaps:	622/1608 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRC 118
            |||||||||||||||||.|||||||||..|:|||||||||||.||||||:|||||||||.:||||
  Rat     1 MKEMVGGCCVCSDERGWAENPLVYCDGHACSVAVHQACYGIVQVPTGPWFCRKCESQERAARVRC 65

  Fly   119 ELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPIILSLIPQERYSKTCYICQEIGKPN 183
            ||||.:|||||:|||.||||||||||||||:|.||.|||||:|..:|.:|::||||||:|.|:.:
  Rat    66 ELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVLTMEPIVLQYVPHDRFNKTCYICEEQGRES 130

  Fly   184 RANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPP 248
            :|..||||.||:..|:|.|||||||..||||||....:|||||||||::|:||:|
  Rat   131 KAASGACMTCNRHGCRQAFHVTCAQMAGLLCEEEVLEVDNVKYCGYCKYHFSKMK---------- 185

  Fly   249 YKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSSG 313
                                                ||...|.||          .|...|.|.|
  Rat   186 ------------------------------------TSRHSSGGG----------GGAGGGGSGG 204

  Fly   314 SGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNI 378
            ||                      |.:|..||.                ||||    |||
  Rat   205 SG----------------------SGTSGGGGG----------------TGGG----GSS----- 222

  Fly   379 SNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSY 443
                 |:...|..|.|:                     |.|:|....|...:.....|.......
  Rat   223 -----NSFLSGRRSRSA---------------------SPSTQQEKHPTHHEKGQKKSRKDKERL 261

  Fly   444 KEKHSKSLSKSTS--------SKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKN 500
            |:||.|......|        :.|   |.|:|.|:::.      :||...|.|:|:....|.|.:
  Rat   262 KQKHKKRPESPPSILAPPVVPTAD---KVSATTSSHHE------ASTQETSESSRDSKGRKSSSH 317

  Fly   501 KDSNQVPSATSSLSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHT 565
            ..|::.....|....:|..:...|||:|::::.|||.    ...|.|.|.|:|..
  Rat   318 SLSHKGKKLGSGKGVSSFTSASSSSSSSSSSSSSGGP----FQPAGSSLQSSPDF---------- 368

  Fly   566 LSTNGTGAGSAAGKLQSVSNLSNSS-----------------------------SGFGSDLRSVS 601
                     :|..||:...:...|.                             ||||..:|..:
  Rat   369 ---------AAFPKLEQPEDDKYSKPPAPTPPAPPSPTIPEPPKADLFEQKVVFSGFGPIMRFTT 424

  Fly   602 TSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSST 666
            |:|||    |.....|..:.:..::||:|:||
  Rat   425 TTSSS----SRARAPSPGDYKSPHVSGSGTSA--------------------------------- 452

  Fly   667 ANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVALTPLTDF 731
                            .|.|:..|.||       |.|.|.|                  .|.|..
  Rat   453 ----------------GSHKRMPALSA-------TLGPAEE------------------APETTL 476

  Fly   732 EKEIEKSSKRQRTELSPPTHQTSATAE-VNAPLASSTSASIAVTASATAASAPPATGTTTLGSSI 795
            :::..|:|||.|.  .|...:.|...| ...|.||..:|.:   |..||.:|.|.:|.:.:.|.:
  Rat   477 KEKKHKASKRSRH--GPGRPKGSRGKEGATGPTASLPAAQL---AGFTATAASPFSGGSLVSSGL 536

  Fly   796 SGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNTSSTKHGSN-IK 859
            .|.|..| .|.|..:.:.......:|:|.|                    :||.....||.. ::
  Rat   537 GGLAPRT-FGPSGSLPSLSLESPLLGAGIY--------------------TSNKDPISHGGGMLR 580

  Fly   860 DISSS--SNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASSRSSGAQSQ 922
            .:.|:  |:.......:|:.|.|..|...||       ||:||.|.|||.....|.|..|...|.
  Rat   581 AVCSTPLSSSLLGPTGTSALPRLSRSPFTST-------LPSSSASISTTQVFSLAGSTFSLPASH 638

  Fly   923 HQQQLSNALVGPPMG------GSAGAFH------------GGTTSAGSSSVIQQQSGKSSPALGT 969
                    :.|.|||      ..|.:.|            .||:...|.|.:...|  |.|||..
  Rat   639 --------IFGTPMGTVNPLLTQAESSHTEPDLEDCSFRCHGTSPQESLSSMSPIS--SLPALFD 693

  Fly   970 LVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAPPARRSRSRSGES 1034
            ..|...||            |.|.:|.           ..||.::||.|::.         .||:
  Rat   694 QTSAPCGG------------GQLDSTA-----------PGTTNMEQLLEKQG---------DGEA 726

  Fly  1035 GSSHHHAHAHHHHHHPTHHNSHHQQNPQQQQQLHQQQQQNASSHMHACTNSSSSTSTSTTSSSLS 1099
            |.:                      ..:..:.||..|::|                 ......:.
  Rat   727 GVN----------------------IVEMLKALHALQKEN-----------------QRLQEQIL 752

  Fly  1100 GGTAPATSSSNSKGPSRSGKKRGAAMNKSESTSVATTATPATVAATPAEKQSRHSSPHYSATPTP 1164
            ..||.              |:|...:|...|...     ||..||.||           :..|.|
  Rat   753 SLTAK--------------KERLQILNVQLSVPF-----PALPAALPA-----------ANGPVP 787

  Fly  1165 PPTSTLPPVVSSPVVMLQSLSSSSIDSPPATAAAGATSNSRNTRNNSSNGNHNGEQTSSSSSSSS 1229
            .|...||...||     .|||.|.  |||.....|..    ||.:.||...|:|..:.||||.|.
  Rat   788 GPYGLLPQAGSS-----DSLSISK--SPPGKNCLGLD----NTLSTSSEDPHSGCPSRSSSSLSF 841

  Fly  1230 SSS------------------------------SGGGGTSGAANVVNLLDSPVNMSASGNYRSSS 1264
            .|:                              :|.|...|||.:..:   |:.....|....|.
  Rat   842 HSTPPPLPLLQQSPATLPLALPGAPAPLPPQPQNGLGRAPGAAGLGAM---PMAEGLLGGLAGSG 903

  Fly  1265 NSTGNAL-----------PAASSNASQAKPLN----KKMLRAQQTQLYQQQQQQQQYAPPARSIS 1314
            :...|.|           ||..|.|..|..|.    ...|..||..|.|||:||.|
  Rat   904 SLPLNGLLGGLNGAAAPNPAGLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQ--------- 959

  Fly  1315 PTNLSSASASNSASLTH---LQQQQQSHQQHEDLEILQFTN------TNTTASSNTPTSKPNNRT 1370
              .|....||...:..|   :.|..|..||..:|:.||...      .:..|.|:||.
  Rat   960 --QLQQLLASPQLTPEHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPL------- 1015

  Fly  1371 LDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQMDVPMMPVSAIK 1435
                   .|:.:|..:|..::|                                  |::|..|:
  Rat  1016 -------LSAGTPGLLPTASAP----------------------------------PLLPAGAL- 1038

  Fly  1436 DSPPSSPGSEIGSAMHSATTAPGSLTGASTAATAQPGNVRKRGRKAKDATIAAAAAAAAAAA--- 1497
                               .||.  .|::|:..|                 |||||||.|||
  Rat  1039 -------------------VAPS--LGSNTSLMA-----------------AAAAAAAVAAAGGP 1065

  Fly  1498 ----ALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVS 1541
                |.:|....|.       ||..:.....|...|.|..|..|...|
  Rat  1066 PVLTAQTNPFLSLP-------GADASGNGSKGGVSTGPGPPIYSYGTS 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	40/46 (87%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	77/114 (68%)
Mllt6	XP_038943652.1	PHD_AF10_AF17	7..54	CDD:277049	40/46 (87%)
		ePHD_AF17	61..185	CDD:277179	83/123 (67%)
		CC_AF10	714..768	CDD:411015	15/115 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4291
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004366
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105638
Panther	1	1.100	-	-	O	PTHR13793
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3088
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.050