DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and Jade1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_006500847.1	Gene:	Jade1 / 269424	MGIID:	1925835	Length:	849	Species:	Mus musculus

Alignment Length:	739	Identity:	166/739 - (22%)
Similarity:	242/739 - (32%)	Gaps:	219/739 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            |.||....|...|.:|:||  .|.:.||||||||:.||.|.|.||.|....:.   :|.|||.:.
Mouse   222 CDVCQSPDGEDGNEMVFCD--KCNICVHQACYGILKVPEGSWLCRTCALGVQP---KCLLCPKKG 281

  Fly   126 GALKKTDNSG--WAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANV 187
            ||:|.| .||  |.||.|||:||||..|:...||||. :|.||..|::..|.:|.|       ..
Mouse   282 GAMKPT-RSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNE-------KF 338

  Fly   188 GACMQCNKSNCKQQFHVTCAQSLGL-----LCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIP 247
            ||.:||:..||:..||||||...||     |.|.     |.||:..||..|.|..|
Mouse   339 GASIQCSVKNCRTAFHVTCAFDRGLEMKTILAEN-----DEVKFKSYCPKHSSHRK--------- 389

  Fly   248 PYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSS 312
                            ||:                                      |:..|::.
Mouse   390 ----------------PEE--------------------------------------GLGEGAAQ 400

  Fly   313 GSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSAS---------------NM 362
            .:|...|:.|                |.....|:..|:....|..|..               |:
Mouse   401 ENGAPESSPQ----------------SPLEPYGSLEPNREEAHRVSVRKQKLQQLEDEFYTFVNL 449

  Fly   363 TGGGSVLPGSSNI-------GNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSS 420
            ......|.....:       ..:...:|.|.|..:.......|:......::.......|.....
Mouse   450 LDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQD 514

  Fly   421 ----QSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSSTNSANNN--FTNSSA 479
                ::.|...|.:.....|..   ..:|:.....:|....:...|..||.:||..|  |.||.:
Mouse   515 LERVRNLTYMVTRREKIKRSVC---KVQEQIFTQYTKLLEQEKVSGVPSSCSSALENMLFFNSPS 576

  Fly   480 SSTSS-----------------------------------NSSSTREKSSSK---LSKNKDSNQV 506
            ...::                                   |||.|..|:|.|   |...::..:|
Mouse   577 VGPNAPKIEDLKWHSAFFRKQMGTSLVHPLKKSHKRDAVQNSSGTEGKTSHKQPGLCGRREGLEV 641

  Fly   507 PSATSSLSTTSS-----INTQPSSSTSTATAG------------SGGTGTHVSSSAASGLNSAPS 554
            ..:..||..|.:     .:.|..:...|...|            .|.........:...|.|. .
Mouse   642 SESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRST-D 705

  Fly   555 TTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNS 619
            |:..|.::....::.|.|. ||.|..:.:....|.|      |..|..:.:|.|. |.|||....
Mouse   706 TSQRHLDNTRAATSPGVGQ-SAPGTRKEIVPKCNGS------LVKVPITPASPVK-SWGGFRIPK 762

  Fly   620 NSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGSSSSTANSLTSTSTSSG------ 678
            ..||:....|...|.:            ..|..::|..::..:.....:.|.:.|.:.|
Mouse   763 KGERQQQGEAHDGACH------------QHSDCSHLGVSRAPAKERAKSRLRADSENDGYAPDGE 815

  Fly   679 -SSSNSSSKKRKADSAKSTSSIST 701
             |.|.|.:.::|...|.||.|..|
Mouse   816 MSDSESEASEKKCIHASSTISRRT 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	23/45 (51%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	53/122 (43%)
Jade1	XP_006500847.1	COG5141	115..>543	CDD:227470	103/420 (25%)
Jade1	XP_006500847.1	ePHD_JADE	274..384	CDD:277141	53/122 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870