DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and Brpf3

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001074784.1	Gene:	Brpf3 / 268936	MGIID:	2146836	Length:	1204	Species:	Mus musculus

Alignment Length:	367	Identity:	106/367 - (28%)
Similarity:	151/367 - (41%)	Gaps:	78/367 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KIPSSFNAKLELDSSKDDTIHSTSLNKK-------LVKIKKFKL--------DDMKEMVGG---- 60
            |.|...:|::|.|..::|......:|:|       .|....|:|        ..::....|
Mouse   143 KPPEDLDAEVEYDMDEEDIAWLDMVNEKRRADGHSSVSADTFELLVDRLEKESYLESRSSGAQQS 207

  Fly    61 -------CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRC 118
                   ||||.|:.....|.:::||  .|.:||||.|||:..:|.|.|.||.| .|..:..|.|
Mouse   208 LIDEDAFCCVCLDDECHNSNVILFCD--ICNLAVHQECYGVPYIPEGQWLCRCC-LQSPSRPVDC 269

  Fly   119 ELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKP 182
            .|||::.||.|:|.:..|||||||::||||.|.|...:|||. :..||..|:..|||||::.|
Mouse   270 VLCPNKGGAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKG-- 332

  Fly   183 NRANVGACMQCNKSNCKQQFHVTCAQSLGLLCE-------EAGNYLDNVKYCGYCQHHYSKLKKG 240
                :||.:||:|.||...|||||||..||..:       ........|:...||:.|
Mouse   333 ----LGAAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTTFTVRKTAYCEAH------- 386

  Fly   241 GNVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSG-SAGGSSNVLNASSSA 304
                             |.|.:...::.||       ..::.::....| ..||.......:...
Mouse   387 -----------------SPSVAVARRKGDS-------PRSLSEVGDEDGPKEGGGEEEQEEAEEE 427

  Fly   305 GISAGSSSGS---GVSSSAKQRKSNASSKSSSSSSSSSSSST 343
            |.......||   |||...|........|....:...:.|.|
Mouse   428 GQEGQGGVGSPLKGVSKKGKMSLKQKIKKEPEEAGREAPSIT 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	22/57 (39%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	52/122 (43%)
Brpf3	NP_001074784.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..127
		COG5141	117..>603	CDD:227470	106/367 (29%)
		ePHD_BRPF3	269..386	CDD:277173	52/122 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..464		13/77 (17%)
		Bromo_brd1_like	592..689	CDD:99944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..879
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..1015
		BR140_related	1073..1188	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950