Protein Alignment Alh and T19D12.1

DIOPT Version :9

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001293517.1
• Gene: T19D12.1 / 24104905
• WormBaseID: WBGene00020576
• Length: 1844
• Species: Caenorhabditis elegans
• Alignment Length: 1919
• Identity: 401/1919 - (20%)
• Similarity: 688/1919 - (35%)
• Gaps: 503/1919 - (26%)

  Fly    96 TVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII 160
            |.|:.|..|..|.:|............::...||..|:  :.:.....||..|:  |:|:.....
 Worm    41 TTPSPPPVCPTCPTQTAQCNTNLFSISTQVNNLKWNDD--YNNTNSPAYIDAVK--NITSALTAT 101

  Fly   161 LSLIPQERYSKTCYICQEIGKPNRANV--GACMQCNKSNCKQ--QFHVTCAQSLGLL-CEEAGNY 220
            |:.......|...|....:...|..||  .|..|.:.::...  ...::....||.: .::..|.
 Worm   102 LNTGLNTASSSGFYRVLAVSTTNNVNVQISALRQGSDNSVVAIGNGAISSTSDLGQMPTDKNVNS 166

  Fly   221 L---DNVKYCGYCQHHYSKLKKGGNVKTIP---PYKPIQHDTSSD----SCS------------S 263
            :   ||..|              .:|.|.|   ....||.|..|.    :||            |
 Worm   167 VITSDNTTY--------------SDVTTAPQACDKTIIQSDCPSTVAPVTCSTMPMPTTQPLVTS 217

  Fly   264 PEKEIDSTMNSATTSATIIK--------ITSSSGSAGGSSNVLNASSSAGISAGSSSGS--GVSS 318
            ...|:.:|: :.||:|.|:.        :|:::|.....:...|::.:|..:|.|::.:  ||::
 Worm   218 TAPEVTTTV-AQTTTAPIVTTANTTTQGVTTTAGVTTTVTRAQNSTLAATTTAPSTNTTTQGVTT 281

  Fly   319 SAKQRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSG---SASNMTGGGSVLPGSSNIGNISN 380
            :..:..:..::::|:.::::::|:|...|..::|:...|   :.:..|...||:|
 Worm   282 TVGKTTTVTTAQNSTWAATTTASNTTTQPVVTTSTSTQGISTTTAQATPSSSVIP---------- 336

  Fly   381 SLNNNLPGGSSSTSSAGNVPGGSG--GIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSY 443
                       :|:.....|..:|  ..:|.|.|      :|.:|..|.||::|:|:.|:.::::
 Worm   337 -----------TTTQTTQRPTSTGIPSTVSTSQG------TSSTSPIPSTTQTSSSAPSTYTSNF 384

  Fly   444 KEKHSKSLSKSTSSKDKDGKDSSTNSANNN------FTNSSASSTSSNSSSTREKSSSKLSKNKD 502
            ....:.:|..||.:....|..:|:.|::.|      .|..:.|||..:||||...::...|..|.
 Worm   385 TPSPTTTLLTSTIAPSTQGVPTSSKSSSPNSTPTTTITPGAPSSTLGSSSSTIVSTTITPSTPKV 449

  Fly   503 S----NQVPSATSSLSTTSSINTQPSSS--TSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHS- 560
            |    :|.|:.||:....||.::..||:  |||.|..:.|..|..|:      ...|||:|..:
 Worm   450 STLTLSQSPTPTSTPLVVSSSSSGSSSTVVTSTITPSTQGVPTSTSN------QPTPSTSNPTTP 508

  Fly   561 NHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSEREN 625
            ....|.|.:.|||.|.|......|:...|.|      .|.|::.:||| ..|..|
 Worm   509 KSTVTASPSTTGATSTASPSTITSSAPTSQS------HSPSSTMTSTV-PVTSTF---------- 556

  Fly   626 LSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNKGGS---------------------------- 662
                .|:.:.:|.|:|||.....|:.|.......|.|
 Worm   557 ----ASTTTTVPITVAPGQCYCQSNVAVAFELTSGTSDLDLDIQNFIANYLFFYSGAPYILGDLT 617

  Fly   663 SSSTANSLT---------------STSTSSGSSSNSSSKKRKADSAKSTSSISTSGSA-LEDNNS 711
            .:.||.||.               :..|.||.|           :|..|.:|...|:| :.|..:
 Worm   618 DNRTAISLVPFPNDDTLSDLMTYGAEQTPSGIS-----------AALDTFNILARGNAVISDAFN 671

  Fly   712 LISRYDIKDVQVALTPLTDFEKEIE---------------------KSSKRQRTELSPPTHQTSA 755
            :|.....|..|..:..:.:.::.::                     |||.:.....|.|::..:.
 Worm   672 IIPNITRKGYQGFVILVANSDESVQASVDSATNLKAQGFNVITVAFKSSGKFDVLASQPSYNYTI 736

  Fly   756 ------------------TAEVNAPLASST-------SASIAVTASATAASAP------PATGTT 789
                              |...|...||||       |:::.||...:::.||      |.||||
 Worm   737 VQDADKRYVATLIGNVLNTTYCNNLAASSTTMTSGVYSSTVTVTTQGSSSQAPSSTVTVPTTGTT 801

  Fly   790 TLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGS-----SSNT 849
            :..:|.:|:..||....|:....|.|:.||      |::.::.||.|.|..:.:||     ||..
 Worm   802 SGAASTTGSITSTQQATSTSSVITTGSTSA------PQSSTAVSSTTTSPSTTTGSTPAPQSSTV 860

  Fly   850 SSTKHGS----------NIKDISSSSNQQASTASSS-SAPSLYVSVPLSTANVP------GINLP 897
            :||...|          .:.:...:|..|..|:||: |..|..||...|:..:|      ....|
 Worm   861 ASTTTVSPYTTTECICTTVSNTFGTSTTQGLTSSSAQSTASTGVSTVASSTTIPQGSSSSSPQSP 925

  Fly   898 T-------SSTSSSTTSESHSASSRSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSV 955
            |       ||||::|.:.|.|.|..||.||.                        .:|.||||:|
 Worm   926 TSAQPAQSSSTSAATVTVSSSQSPTSSPAQQ------------------------SSTPAGSSTV 966

  Fly   956 -IQQQSGKSSPALGTLVSGNSGGSIISASGFPLPSGNLTAT-------TTESGNLKISYEKQTTR 1012
             :||.|...||...|.:  .|..::.|.......||..|.|       |...|.:.:.||.....
 Worm   967 TVQQSSSFQSPQSTTQI--GSSTTVPSTQAPSSTSGGPTTTQICPNQQTVFKGQVGVIYEMLPAS 1029

  Fly  1013 VQQLQEQEAPPARRSRSRSGESGSSHHHAHAHHHHH----------HPTHHNSHHQQNPQQQQQL 1067
            .||       .|..:...:....|:.:.....:..|          :||....:.|.....:...
 Worm  1030 TQQ-------NAINAFVENVLLNSNFYGLALDNLTHDNRTLVTAIPYPTTDKYNVQGYGSARSVD 1087

  Fly  1068 HQQQQQNASSHMHACTNSSSSTSTS----TTSSSLSGGTAPATSSSNSK------GPSRSGKKR- 1121
            ..:.|..|.:.|....:.|||.|.:    |||....|..:......||.      .|..:.:.|
 Worm  1088 EFRNQVIAFNGMIQPISQSSSISDALLYVTTSLPAGGVKSSLIIVGNSAAMIDNIAPILTNQLRS 1152

  Fly  1122 -----------GAA--MNKSESTSVATTATPATVAATPAEKQSRHSSPHYSATPTP----PPTST 1169
                       ||.  ...|..|..:.|.....||.....|.:..:...|...|.|    |.|||
 Worm  1153 DFDIYTVGVGSGAVDLSPLSSGTGFSFTGDTQQVADQIGLKMASSNPSVYCPPPVPSTAAPSTST 1217

  Fly  1170 LPPVVSSPVVML----------------------------QSLSSSSIDSPPATAAAGATSNS-- 1204
            ..|..:.||...                            .:::..:|.:..:.:.|...||:
 Worm  1218 AVPTTTVPVTTTIATTTRVTTVRPTVGPCQCTGRWVYNGDLAIAFENIKTNGSQSVANFLSNTLL 1282

  Fly  1205 RNTRNNSSNGNHNGEQTSSSS-----SSSSSSSSGGGGTSGAANVVNLLD--SPVNMSASGNYRS 1262
            :|..:.....:.||.|.|..:     .|::..:...|......::.|.:|  ||:.::......|
 Worm  1283 KNPDSYGLTNDVNGNQPSQLTLIPYPDSNTYPTYPYGWIRSVNDIGNYIDAISPLPLATPDPQIS 1347

  Fly  1263 SS-------------------NSTGNALPAASSNASQAKPLNKKMLRAQQT---QLYQQQQQQQQ 1305
            .:                   .|.|..:.||..:|::.|.....::...||   .::|......|
 Worm  1348 DALTFISAQPTTLNSKVVLLVGSNGTDVNAAMDSANKLKNAGYLVITVAQTAAASVFQPLASGSQ 1412

  Fly  1306 YAPPARSISPTNLSSASASNSASLTHLQQQQQSHQQHEDLEILQFTNTNTTASSNTP-------- 1362
            :   |..|...| ..|.|:..||:                 :|.::.|.....|:||
 Worm  1413 F---ALHIGDGN-DDAVAAQIASM-----------------LLDYSFTCFDDGSSTPSPTTRCPG 1456

  Fly  1363 ---TSKPNNRTLDLSTASASSSSPSAVPATTSPLVVLSNQLPLNSVAASSSTGGLKFTYESQTQM 1424
               |::|......::...:|||..|..|..:|.:..:::...:.|.|.|||
 Worm  1457 TQGTTQPGTIGTTVTVPPSSSSIGSTAPQGSSSIQPIASSSTMGSTAGSSS-------------- 1507

  Fly  1425 DVPMMPVSAIKDSPPSSPGSEIGSAMHSATTAPGSLTGA---STAATAQPGNVRKRGRKAKDATI 1486
              |...||:  .|.|||.|:   ::..|:||...|..||   |.:::..| |....|....:.:.
 Worm  1508 --PQPTVSS--TSVPSSTGA---TSSGSSTTVGSSTVGATQTSVSSSTVP-NTGSTGSTVTNPST 1564

  Fly  1487 AAAAAAAAAAAALSNSQQDLKDVRILQNGASNTPGNPAGSTPTPPATPASSNAVSSASSIITHTA 1551
            :::.:.:::..::.:|        ...|..|:|.|....:|....:|..:||..|:..:......
 Worm  1565 SSSTSGSSSTQSIPSS--------TAANTGSSTSGPTVATTQGSSSTQTNSNTGSTTVATTVTQG 1621

  Fly  1552 AHMLGNQ----IN-PNSSVAQKL-SEQLHMEVQDHSIYTPDSMNSQYAGVPFPGKQRNSTAVPSN 1610
            :...||.    :| .:||||..: |...::|.....|.|..|        |:.||  .:|....|
 Worm  1622 SSTGGNSGSTTVNFQSSSVASTVASSTANIESSTTPIPTCAS--------PYSGK--IATVFELN 1676

  Fly  1611 ATPAQNPLQSMFSGGGMNGNMPIPQSLEQLLERQWEQGSQFLMEQAQHFDIASLLNCLHQLQSEN 1675
            |..|.|.:..:.:....:.|.....|.| .:...:.|...:..:..|:....||.|
 Worm  1677 ANSATNIVNFVSNNLYNSANYDFTNSTE-AINVPYGQTDHYATQILQYNGTKSLSN--------- 1731

  Fly  1676 LRLEEHVTSLIARRDHLLAVNARLQIPLSTIASN 1709
              |:::|:.|:.  ..:|.::|.:...|..:.:|
 Worm  1732 --LQDNVSDLLT--SAILLIDATISDGLQWLQTN 1761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	4/10 (40%)
		ePHD_AF10_like	118..233	CDD:277142	22/122 (18%)
T19D12.1	NP_001293517.1	SEA	64..>137	CDD:279699	16/76 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000