DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alh and BRD1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001291737.1	Gene:	BRD1 / 23774	HGNCID:	1102	Length:	1189	Species:	Homo sapiens

Alignment Length:	213	Identity:	85/213 - (39%)
Similarity:	112/213 - (52%)	Gaps:	36/213 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            ||:|.|......|.:::||  .|.:||||.|||:..:|.|.|.||.| .|.|.....|.|||::.
Human   217 CCICMDGECQNSNVILFCD--MCNLAVHQECYGVPYIPEGQWLCRHC-LQSRARPADCVLCPNKG 278

  Fly   126 GALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVGA 189
            ||.||||:..|.||||||:||||.|.|...:|||. :..||..|:..|||:|::.|      |||
Human   279 GAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG------VGA 337

  Fly   190 CMQCNKSNCKQQFHVTCAQSLGLLCE-------EAGNYLDNVKYCGYCQHH------------YS 235
            |:||:|:||...|||||||..||..:       ..|....:|:...||..|            |.
Human   338 CIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYG 402

  Fly   236 KL-------KKGGNVKTI 246
            .:       :|..:|||:
Human   403 DVEMKNGVCRKESSVKTV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/45 (44%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	56/122 (46%)
BRD1	NP_001291737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Interaction with KAT7/HBO1 and histones. /evidence=ECO:0000269\|PubMed:28334966	31..80
		EPL1	47..196	CDD:287484
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..116
		PHD_BRPF2	214..267	CDD:277147	23/52 (44%)
		ePHD_BRPF2	271..388	CDD:277172	56/122 (46%)
		Bromo_brd1_like	566..663	CDD:99944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..776
		BR140_related	1058..1173	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950