Protein Alignment Alh and Brd1

DIOPT Version :10

• Sequence 1: NP_001262332.1
• Gene: Alh / 40850
• FlyBaseID: FBgn0261238
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001028446.2
• Gene: Brd1 / 223770
• MGIID: 1924161
• Length: 1189
• Species: Mus musculus
• Alignment Length: 1115
• Identity: 235/1115 - (21%)
• Similarity: 355/1115 - (31%)
• Gaps: 339/1115 - (30%)

  Fly    22 AKLEL--DSSKDDTIHSTSLNKKLVKIKKF---------KLDDMKEMV---GGCCVCSDERGWPE 72
            |.||:  :..|.|.:.:.|.|.....:.:|         |..:.:.::   ..||:|.|......
Mouse   164 AWLEIINEKRKGDCVSAVSQNMFEFLMDRFEKESYCENQKQGEQQSLIDEDAVCCICMDGECQNS 228

  Fly    73 NPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWA 137
            |.:::||  .|.:||||.|||:..:|.|.|.||.| .|.|.....|.|||::.||.||||:..|.
Mouse   229 NVILFCD--MCNLAVHQECYGVPYIPEGQWLCRHC-LQSRARPADCVLCPNKGGAFKKTDDDRWG 290

  Fly   138 HVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQ 201
            ||||||:||||.|.|...:|||. :..||..|:..|||:|::.|      ||||:||:|:||...
Mouse   291 HVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG------VGACIQCHKANCYTA 349

  Fly   202 FHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIQHDTSSDSCSSPEK 266
            |||||||..||                     |.|::                         |.|
Mouse   350 FHVTCAQKAGL---------------------YMKME-------------------------PVK 368

  Fly   267 EIDSTMNSATTSATIIKITSSSGSAGGSSNVLN----ASSSAGISAGSSSGSGVSSSAKQRKSNA 327
            |:  |..|||.|.............|.:...||    .....|:....||...|.|::|.||...
Mouse   369 EL--TGGSATFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAK 431

  Fly   328 SSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSS 392
            .:|.:.:...                             :|||
Mouse   432 KAKKTLAEPC-----------------------------AVLP---------------------- 445

  Fly   393 TSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASS-SSSSSNSYKEK-HSKSLSKST 455
            |..|..:|                         |......|:. :......:.|: ||..|.|..
Mouse   446 TVCAPYIP-------------------------PQRLNRIANQVAIQRKKQFVERAHSYWLLKRL 485

  Fly   456 SSKDKDGK------DSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKN-------------- 500
            |   ::|.      .||..|..|  |....:.....::..:.|...:|..:
Mouse   486 S---RNGAPLLRRLQSSLQSQRN--TQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKR 545

  Fly   501 ----KDSNQVPSATSSLSTT------------------SSINTQPSSSTSTATAGSGGTGTHVSS 543
                ::..:|......|..|                  :.|..||.|
Mouse   546 EKLKREQVKVEQMAMELRLTPLTVLLRSVLEQLQEKDPAKIFAQPVS------------------ 592

  Fly   544 SAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFGSDLRSV-----STS 603
                 |...|... :|..|....:|.....     :.|...||    ..|..|...:     ..:
Mouse   593 -----LKEVPDYL-DHIKHPMDFATMRKRL-----EAQGYKNL----HAFEEDFNLIVDNCMKYN 642

  Fly   604 SSSTV--------NDSTGGFGSNSNSERENLSGAGSSASNMP-GTIAPGTGGVSSSAATNLSTNK 659
            :..||        .|..|.....:..|.|::....:|..::| ..||......|......|....
Mouse   643 AKDTVFYRAAVRLRDQGGVVLRQARREVESIGLEEASGMHLPERPIAAPRRPFSWEEVDRLLDPA 707

  Fly   660 GGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSALEDNNSLISRYDIKDVQVA 724
            ..:..|....|                :...|....|.|:.:|||..:       |..:...::|
Mouse   708 NRAHMSLEEQL----------------RELLDKLDLTCSMKSSGSRSK-------RAKLLKKEIA 749

  Fly   725 LTPLTDFEKEIEKSSKRQRTELSPPTHQ-TSATAEVNAPLASST-------------SASIAVTA 775
            |.          ::...|:...:|||.. |....:..||||..|             |.::.:.:
Mouse   750 LL----------RNKLSQQHSQAPPTGAGTGGFEDEAAPLAPDTAEEGANSPPKLEPSDALPLPS 804

  Fly   776 SATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAG 840
            ::...|.||......|....|......:..|.|..:.|   |||:.| |:|...:..|||...|.
Mouse   805 NSETNSEPPTLNPVELHPEQSKLFKRVTFDNESHSTCT---QSALVS-GHPPEPTLASSGDVPAA 865

  Fly   841 SGSGSSSNTSSTKHGSNIKDISSSS-NQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSS 904
            :.|..:..:|.....:::....|.| :...|..::.:.|:   |..|.|.....:.||...|...
Mouse   866 AASAVAEPSSDVNRRTSVLFCKSKSVSPPKSAKNTETQPT---SPQLGTKTFLSVVLPRLETLLQ 927

  Fly   905 TTSESHSASSRSSGAQSQHQQQLSNALVG---------PPMGGSAGAFHGGTTSAGSSSVIQQQS 960
            ....|.|....|...:....::|...|..         .|.||...........|..||:....|
Mouse   928 PRKRSRSTCGDSEVEEESPGKRLDTGLTNGFGGARSEQEPGGGPGRKAAPRRRCASESSICSSNS 992

  Fly   961 ------------GKSSPAL---------GTLVSGNSGGSIISASGFPLPSG--NLTATTTESGN- 1001
                        |:..|||         ..|:|....|:...|:......|  |:..:|..:.:
Mouse   993 PLCDSSFSTPKCGRGKPALVRRHTLEDRSELISCIENGNYAKAARIAAEVGQSNMWISTDAAASV 1057

  Fly  1002 ---LKISYEK 1008
               ||:.:.|
Mouse  1058 LEPLKVVWAK 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/46 (43%)
		ePHD_AF10_like	118..233	CDD:277142	52/115 (45%)
		CC_AF10	1636..1699	CDD:411015
Brd1	NP_001028446.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Interaction with KAT7/HBO1 and histones. /evidence=ECO:0000250|UniProtKB:O95696	31..80
		EPL1	47..196	CDD:463128	8/31 (26%)
		COG5141	139..>572	CDD:227470	131/545 (24%)
		ePHD_BRPF2	271..388	CDD:277172	62/170 (36%)
		Bromo_brd1_like	566..663	CDD:99944	18/129 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..776		5/21 (24%)
		PWWP_BRPF2	1058..1177	CDD:438985	3/10 (30%)