DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and lin-49

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_501475.1	Gene:	lin-49 / 177666	WormBaseID:	WBGene00003034	Length:	1042	Species:	Caenorhabditis elegans

Alignment Length:	819	Identity:	179/819 - (21%)
Similarity:	290/819 - (35%)	Gaps:	182/819 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 KFKLDDMKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQER 112
            |.|.::.:|:...|.:|.|......|.:||||  .|.::|||.||||..:|.|...||:| ....
Worm   185 KLKDENGEELDDVCNICLDGDTSNCNQIVYCD--RCNLSVHQDCYGIPFIPEGCLECRRC-GISP 246

  Fly   113 TSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPI-ILSLIPQERYSKTCYIC 176
            ..||.|.||||..||.|:.|...|.||:|.:::.|..|||...||.: .:.....:|.:.:|.:|
Worm   247 AGRVNCVLCPSTTGAFKQVDQKRWVHVLCVIWVDETHFGNTIFMENVQNVEKALHDRRALSCLLC 311

  Fly   177 QEIGKPNRAN--VGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKL-- 237
            :     ||.|  :|||:||:::.|...||||||:..||:..........|....:|..|...|
Worm   312 K-----NRQNARMGACIQCSETKCTASFHVTCARDSGLVMRINETEDGQVNRFVWCPKHAPPLTD 371

  Fly   238 ------------------KKG----------GNVKTIPPYKPIQHDTSSDSCSSPEKEIDS---- 270
                              :||          ..:.||...:|.. |.|.......||.::.
Worm   372 ADREMRQLMLRNARRENERKGPMISMPTLMKSMISTICVERPFS-DYSEIIYFWYEKRLNRLGAP 435

  Fly   271 -TMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGSSS-GSG------VSSSAKQRKSNA 327
             ..|....::...::...|...|...||........::|...| .||      :....:::|...
Worm   436 LLKNFTQGASKSRRLLPKSTICGQLKNVETCEMKKQVNAVKESLASGLEIFDMIVRREERKKDML 500

  Fly   328 SS---------------------------------------------------KSSSSSSSSSSS 341
            :|                                                   |..|..::|...
Worm   501 NSYIRMFERGFKPTELLCQEVIEALKTIDAGKVFAEPVELVGYTDIIENPICLKDMSEKAASGKY 565

  Fly   342 STGGAPNPSSSSVHSGSASNMTG-------GGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNV 399
            ||..|.:.....:.|..|:...|       |.:....|:.|..|:...........:.......:
Worm   566 STVAALSADVQLMLSNCATFNKGNRVYIKYGNTYRKDSTPILEIAEKEEVERLALKTDEKFMTQL 630

  Fly   400 PGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKD 464
            ..|    :.....|..||.:..:...|..|.|....:.      :.:.:..|.......| |.||
Worm   631 LNG----VMVEYNGWAQSRNEVAKEIPPPTPSRGRGTG------RRRQNPFLDVQELDTD-DSKD 684

  Fly   465 SSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTST 529
            |           |:.|....:|..:..|...:.:|.::..::..:||..:..:|:....||..|.
Worm   685 S-----------SALSEIPGSSKKSSRKRGIQDTKMEEDEEIKPSTSGTNAVASVPLLSSSRESK 738

  Fly   530 ATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQSVSNLSNSSSGFG 594
            ..:.|  :...|||..:|.|.| |||:..........|  |..:.....|..|..|.||
Worm   739 NKSKS--SDADVSSPKSSWLGS-PSTSQNLRRRVQGFS--GNESSPKVHKKLSTDNPSN------ 792

  Fly   595 SDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPGTGGVSSSAATNLSTNK 659
            |:||..:.         |..||:|..::::      .:.::|  |..|...|..:.:..:|....
Worm   793 SNLRQTTL---------TNFFGTNPKTQQQ------VTFADM--TATPSGSGNKNVSQRSLFDTP 840

  Fly   660 GGSSSSTANSLTSTSTSSGSSS-----NSSSKKRKADSA-----KSTSSISTSGSALEDNNSLIS 714
            ..|.:|:..||:||..|:.|:|     |..:..|.:.::     .:|..|.....|.:|..
Worm   841 STSKASSFTSLSSTRPSTRSTSIIPTINKKNAFRMSSASIQSPLPTTKKIGVRAMATDDEE---- 901

  Fly   715 RYDIKDVQVALTP--LTDFEKEIEKSSKRQRTELSPPTH 751
                :|:.:...|  :|..|.|.||....:...:|...|
Worm   902 ----EDIVIQPPPKEMTTQELEAEKLKSAENEAMSKFAH 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/46 (43%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	41/117 (35%)
lin-49	NP_501475.1	EPL1	<61..174	CDD:287484
		PHD_BRPF_JADE_like	197..242	CDD:276967	20/46 (43%)
		zf-HC5HC2H_2	251..365	CDD:290544	41/118 (35%)
		BROMO	508..610	CDD:197636	12/101 (12%)
		Sporozoite_P67	642..>1029	CDD:253298	75/349 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13793
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.050