DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and zfp-1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_001379957.1	Gene:	zfp-1 / 176237	WormBaseID:	WBGene00006975	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	1062	Identity:	287/1062 - (27%)
Similarity:	415/1062 - (39%)	Gaps:	311/1062 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 MKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQE------- 111
            |||||||||||:||.||.:|||:||||:||.|||||.||||..||.|.|:|.||....
Worm     1 MKEMVGGCCVCADENGWTDNPLIYCDGENCEVAVHQGCYGIQEVPEGEWFCAKCTKASAMMPGSI 65

  Fly   112 RTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPIILSLIPQERYSKTCYIC 176
            ..:...|:|||...|||||||.:|||||:|||||||||||||.:|||:||:.:|.::::|.||||
Worm    66 NEATFCCQLCPFDYGALKKTDRNGWAHVICALYIPEVRFGNVHSMEPVILNDVPTDKFNKLCYIC 130

  Fly   177 QEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGG 241
            .| .:||.|..||||.||||.||:.|||||||..|||||| |....||||||||::|..|.....
Worm   131 NE-ERPNDAKKGACMSCNKSTCKRSFHVTCAQRKGLLCEE-GAISRNVKYCGYCENHLKKAINDP 193

  Fly   242 NVKTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTS-------------ATIIKITSSSGSAGG 293
            .:|.||...|:|.         ..||.|.......||             |..:.|.|:.
Worm   194 AIKVIPACPPVQR---------LSKEQDKKKTVLLTSLPLPPPAPRLHMLADPLPIKSNK----- 244

  Fly   294 SSNVL---NASSSAGISAGSSSGSGVSS--------------SAKQRKSNASSKSSSSSSSSSSS 341
            .:|||   :|.::..:....:|||.|:|              :...|.|.|...|...:.:.:|.
Worm   245 VNNVLGLGSAINAVSLEERPASGSTVNSGIFVPPPTAFSPPLTTSSRSSVAQDPSPPLTINKNSL 309

  Fly   342 STGGAPNPSSS--SVHSGSASNMTGGGSVLPGSS--NIG--------------------NISNSL 382
            |:.|...||::  |..:.||:.:...||.||.||  .:|                    .|..|.
Worm   310 SSSGPLIPSTAHLSATTASATPIMANGSTLPPSSETTVGTHCLQQLQIQSAAAAAITQNQIGPSE 374

  Fly   383 NNNLPGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKH 447
            .|..|..|..:|....:|             |..:||..|...||..:...:.|..     :||.
Worm   375 LNGYPAASQLSSFMHEIP-------------ARNTTSVASLLPPGAAEYHLNGSGD-----EEKT 421

  Fly   448 SKSLSKSTSSKDKDGKDSSTNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSS 512
            .|::..:..:|.|..:||..:..:                        |..|...:|..|
Worm   422 VKAVLTAPLTKAKRIRDSKNDMMD------------------------KTHKRPRANARP----- 457

  Fly   513 LSTTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAA 577
                      |:...|.::..||||                                       .
Worm   458 ----------PAVLGSMSSGSSGGT---------------------------------------V 473

  Fly   578 GKLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAP 642
            ||..|:..|.|          .|:...|.||.|    |..:..::|.......::|.:.|.|...
Worm   474 GKSPSMQRLQN----------LVAPIVSETVTD----FQRDRVADRTAAERRAAAAQSQPSTSTN 524

  Fly   643 GTGGVSSSAATNLSTNKGGSSSSTANSLT-----STSTSSGSSSNSSSKKRKADSAKSTSSISTS 702
            |...|:..|...:.||...|::...|.||     |||..:|:|||.....:...|:.|.|:....
Worm   525 GGPNVTIPAVVEVHTNSTNSTNHQNNGLTQNAPASTSMQAGTSSNDGVISQNGTSSTSQSNRLNL 589

  Fly   703 GSALE--------DNNSLI---SRYDIKDVQVALTPLTDFEKEIEKS------------------ 738
            .|.:|        ..:||:   :.:|:..:...|..|......:|::
Worm   590 PSFMEQLLERQWDQGSSLLMANAHFDVAQLLSCLFQLKSENFRLEENLSGLRKRRDHLFALNSRL 654

  Fly   739 --------SKRQRTE-----------LSPPTHQTSATAEVNAPLASSTSASIAVTASATAASAPP 784
                    |||||::           |.|.:....|......||::.||..:            |
Worm   655 AEVNTLDVSKRQRSDGLLLQQQIAHHLDPTSIVPKAEVHKQEPLSAPTSVPL------------P 707

  Fly   785 ATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQSAVGSGGYPKTESSKSSGTASAGSGSGSSSNT 849
            |..:::|...|.....:.|....|.:..|           .|.:.::.:..|.:|.| ||:..|:
Worm   708 ANHSSSLFEDIKAPKATYSRKTPSNIPLT-----------VPLSTAATALTTTTAAS-SGAPVNS 760

  Fly   850 SSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPTSSTSSSTTSESHSASS 914
            :...|              .:|.|::.||  ..:.|:.||               .||.:..|:.
Worm   761 NIQNH--------------RATPSTAGAP--MAATPIMTA---------------VTSANELAAL 794

  Fly   915 RSSGAQSQHQQQLSNALVGPPMGGSAGAFHGGTTSAGSSSVIQQQSGKSSPAL-GTLVSGNSGGS 978
            ....||:     |.| :...|:..:.         |...|:|....|:.:|:| ..|::.|....
Worm   795 SPERAQA-----LLN-MYRMPLDANV---------AAQLSMITNFPGQVNPSLFSRLLAVNMMNG 844

  Fly   979 IISASGFPLPSGNLTATTTESG 1000
            .:..:|.||.:.....:.|.:|
Worm   845 GLQPNGQPLSALPPPTSATPNG 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	32/46 (70%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	76/114 (67%)
zfp-1	NP_001379957.1	PHD_AF10_AF17	7..54	CDD:277049	32/46 (70%)
		ePHD_AF10_like	72..185	CDD:277142	76/114 (67%)
		CC_AF10	593..654	CDD:411015	7/60 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166786
Domainoid	1	1.000	171	1.000	Domainoid score	I2255
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3355
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	1	1.000	-	-		FOG0004366
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105638
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X3088
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.920