DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and phf-15

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	NP_497691.1	Gene:	phf-15 / 175435	WormBaseID:	WBGene00021810	Length:	741	Species:	Caenorhabditis elegans

Alignment Length:	561	Identity:	120/561 - (21%)
Similarity:	194/561 - (34%)	Gaps:	181/561 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KQVTSSNKIPSSFNAKL--ELDSSKDDTIHSTSLNKKLVKIKKFKLDDMKEMVGG----CCVC-- 64
            |.:|....:|.:...::  ||::.....||:..|:...|...:...|      ||    |.||
Worm   228 KLLTGDTYLPMATFIRIIKELETEAFKQIHNHLLDSLHVVYCRPPED------GGEDAECDVCRI 286

  Fly    65 -----SDERGWPENPLVYCDGQNCTVAVHQACYGIVTV--PTGPWYCRKCESQERTSRVRCELCP 122
                 :||       :|:||  .|...||..|.||..:  |..||.|.|| :...|....|.|||
Worm   287 SDCDVADE-------MVFCD--MCNTCVHMVCAGIEELPDPAEPWKCAKC-AHMGTPCPPCVLCP 341

  Fly   123 SRDGALK-KTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRA 185
            :..|::. ..|.:.|||..|||:|||:.|.|.....|:. ...:.:||:|:.|.:|.       .
Worm   342 ALGGSMTYSADKTQWAHHSCALFIPEIIFENEELRAPMTSFERVAEERWSQMCSVCD-------T 399

  Fly   186 NVGACMQCNKSNCKQQFHVTCAQSLGLL--CEEAGNYLD-NVKYCGYCQHH-------------- 233
            ..|||:.|:..:|::.:||.||...|:.  .:|..|..: ||....||..|
Worm   400 RQGACVTCSWVDCEETYHVCCALRAGMTVRIQEVPNDPEHNVTRVTYCHKHTHPQDVIIEDKYRT 464

  Fly   234 --------------------------------------YSKLKKGGNVKTIPPY-------KPIQ 253
                                                  |.|.::.....::.|:       :|:.
Worm   465 YRNPWLAKMETVFFLMTDYEMIAERLQMEEIIVSDVYEYWKQRRMSRGTSLIPHLHDHVLIEPVI 529

  Fly   254 HDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNAS----------------- 301
            |..:        :::...:::|..:|.|     |:||...::...|.:
Worm   530 HRVA--------RKVGENLDAAMKTAGI-----STGSCPSTTTNTNGAQFFRPAALMVTEFRQYN 581

  Fly   302 ---SSAGISAGSSSGSGVSSSAKQRKSNASSKSSSSSSSSSSSSTGGAPNP-------SSSSVH- 355
               ::..|.......|.:....:.:|...|:::.....:......|.||..       |.|.:.
Worm   582 LKRAAESIQRDLQMFSMLQRREQLKKEQISAENRQFHVAWQLLQRGLAPGAVLEAMKISKSEIRK 646

  Fly   356 --SGSASNMTGGGSVL---------PGSSNIGNISNSLNNNLPGGSSSTSSAGNVPGGSGGIISA 409
              |.||.|..  .|||         ||.|:|.::.:         ..|.....|.|...|    |
Worm   647 FTSESAKNSM--FSVLAEPSLKRKHPGISHIPHMEH---------QKSPLRPRNAPAHHG----A 696

  Fly   410 SSGGATQSTSSQSSTAPGT------------TKSSASSSSS 438
            |:||.......:|.:|.|.            ||..|..|::
Worm   697 SNGGRAPREDERSPSARGAQNIEVMGVSKRITKKPARISTN 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	19/59 (32%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	39/119 (33%)
phf-15	NP_497691.1	PHD_BRPF_JADE_like	281..327	CDD:276967	18/54 (33%)
phf-15	NP_497691.1	zf-HC5HC2H_2	336..450	CDD:290544	39/120 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940