DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and Mllt10

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_006497436.2	Gene:	Mllt10 / 17354	MGIID:	1329038	Length:	1101	Species:	Mus musculus

Alignment Length:	1450	Identity:	392/1450 - (27%)
Similarity:	551/1450 - (38%)	Gaps:	471/1450 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SSKDDTIHSTSLNKKLVKIKKFKLDDMKEMVGGCCVCSDERGWPENPLVYCDGQNCTVAVHQACY 92
            |.:|:..||                 ||||:||||||||||||.|||||||||..|:||||||||
Mouse     9 SLEDEVSHS-----------------MKEMIGGCCVCSDERGWAENPLVYCDGHGCSVAVHQACY 56

  Fly    93 GIVTVPTGPWYCRKCESQERTSRVRCELCPSRDGALKKTDNSGWAHVVCALYIPEVRFGNVTTME 157
            |||.||||||:|||||||||.:||||||||.:|||||:|||.||||||||||||||:|.||:|||
Mouse    57 GIVQVPTGPWFCRKCESQERAARVRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTME 121

  Fly   158 PIILSLIPQERYSKTCYICQEIGKPNRANVGACMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLD 222
            ||:|..:|.:||:||||||.|.|:.::|..||||.|||..|:|.|||||||..||||||.||..|
Mouse   122 PIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGAD 186

  Fly   223 NVKYCGYCQHHYSKLKK---GGNVKTIPPYKPIQHDTSSDSCSSPE-------KEID-------- 269
            ||:|||||::|:|||||   |.|    ..|:....|:||.|.....       ||.|
Mouse   187 NVQYCGYCKYHFSKLKKSKRGSN----RSYEQSLSDSSSHSQDKHHEKEKKKYKEKDKHKQKHKK 247

  Fly   270 ------STMNSATTSATIIKITSSSGSAGGSSNVLNASSS-------AGISAGSSSGSGVSSSAK 321
                  :.:.|.|.:......::|:.|..||...|..:::       ..:||.:|||..||.:
Mouse   248 QPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDVSEA-- 310

  Fly   322 QRKSNASSKSSSSSSSSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNL 386
             |.|....|.||:.||.......||.....::|                          |.::..
Mouse   311 -RGSEGKGKKSSAHSSGQRGRKPGAGRNPGTAV--------------------------SASSPF 348

  Fly   387 PGGSSSTSSAGNVPGGSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSL 451
            |.||.|         |:.|.:.:|||.:.||.....|......:|.:.:.:...:|.|:.|.
Mouse   349 PQGSFS---------GTPGSVKSSSGSSVQSPQDFLSFTDSDLRSDSYTHTQQPSSTKDVHK--- 401

  Fly   452 SKSTSSKDKDGKDSSTNSANNNFTN---SSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSL 513
                      |:..|..:|.|:|::   ...:||..:...:.:.|..:|.    |:.:|:|....
Mouse   402 ----------GESGSQEAAVNSFSSLVGHPVTSTVISQPKSFDNSPGELG----SSSLPTAGYKR 452

  Fly   514 STTSSINTQPSSSTSTATAGSGGTGTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAG 578
            :.||.|..:.                 |......|        |:.|.|         |.|...|
Mouse   453 AQTSGIEEEA-----------------VKEKKRKG--------NKQSKH---------GPGRPKG 483

  Fly   579 KLQSVSNLSNSSSGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMPGTIAPG 643
                                                     |..:||:|....|:::...::|..
Mouse   484 -----------------------------------------NKNQENVSHLSVSSASPTSSVASA 507

  Fly   644 TGGVSSSA---ATNLSTNKGGSSSSTANSLTSTSTSSGSSSNSSSKKRKADSAKSTSSISTSGSA 705
            .|.|:||:   :..|..|         .||.|.|..|....:..|.:.:.|.|..|::.|...:|
Mouse   508 AGSVTSSSLQKSPTLLRN---------GSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNA 563

  Fly   706 LEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTSATAEVNAPLASSTSAS 770
            :  :|.:   |:..||.|                                              |
Mouse   564 I--HNGI---YNSNDVAV----------------------------------------------S 577

  Fly   771 IAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSA-TGGAQSAVGSGGYPKTESSKSS 834
            .....|.:.:|.|.:          |.:....|||:...|.| :..|.|:|          :.::
Mouse   578 FPNVVSGSGSSTPVS----------SSHIPQQSSGHLQQVGALSPSAASSV----------TPAA 622

  Fly   835 GTASAGSGSGSS-SNTSSTKHGSNIKDISSSSNQQASTASSSSAPSLYVSVPLSTANVPGINLPT 898
            .|..|.:.|||| |...:..:||.:....|.:...|.:.||.:...|            |.|..:
Mouse   623 ATTQANTVSGSSLSQAPAHMYGSRLNQNPSMAVLIAQSESSQTDQDL------------GDNARS 675

  Fly   899 SSTSSSTTSESHSASSRSSGAQSQHQQQLSNAL-VGPPMGGSAGAFHGGTTSAGSSSVIQQQSGK 962
            .....|:...|.|..|..|..|.::.|..:::| ..||:..|.........|.|...:::|  |.
Mouse   676 LGGRGSSPRGSLSPRSPVSNLQLRYDQPSNSSLETVPPVAASIEQLLERQWSEGQQFLLEQ--GT 738

  Fly   963 SSPALGTLVSGNSGGSIISASGFPLPSGNLTATTTESGNLKISYEKQTTRVQQLQEQEAP----- 1022
            ....||.|.|                   |.....|:..|:...:..|.:.::||...|.
Mouse   739 PGDILGMLKS-------------------LHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPF 784

  Fly  1023 PARRSRSRSGESGSSHHHAHAHHHHHHPTHHNSHHQQNPQQQQQLHQQQQQNASSHMHACTNSSS 1087
            ||..:                                ||....|:|....|
Mouse   785 PAITT--------------------------------NPSPSHQMHTYTAQ-------------- 803

  Fly  1088 STSTSTTSSSLSGGTAPATSSSNSKGPSRSGKKRGAAMNKSESTSVATTATPATVAATPAEKQ-- 1150
                          |||...|                :|.|:|..:..:..|..  :.|...|
Mouse   804 --------------TAPPPDS----------------LNSSKSPHIGNSFLPDN--SLPVLNQDL 836

  Fly  1151 --SRHSSPHYSATPTPPPTSTLPPVVSSPVVMLQSLSSSSIDSPPATAAAGATSNSRNTRNNSSN 1213
              |..|:...||..||||....|...||.|..:|.::..::         ||.:
Mouse   837 TSSGQSTSSSSALSTPPPAGQSPAQQSSGVSGVQQVNGVTV---------GALA----------- 881

  Fly  1214 GNHNGEQTSSSSSSSSSSSSG------G-----GGTSGAANVVNLLDSPVNMS---ASGNYRSSS 1264
               :|.||.:|:..:.|:..|      |     .|..||.|  .::.:||.:|   |...:.|..
Mouse   882 ---SGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALN--GVIQTPVTISQNPAPLTHTSVP 941

  Fly  1265 NSTGNALPAASSNASQAKPLNKKMLRAQQTQLYQQQQQQQQYAPPARSISPTNLSSASASNSASL 1329
            .:..:.:|||:...| |..|.  :|..||.|::.||||.||..                 ||..|
Mouse   942 PNAAHPMPAAALTNS-ASGLG--LLSDQQRQMFIQQQQFQQLL-----------------NSQQL 986

  Fly  1330 THLQQQ----QQSHQQHE--DLEILQFTNTNTTASSNTPTSKPNNRTLDLSTASASSSSPSAVPA 1388
            |..|.|    |...|||.  :|:.||...         ||..|.|..|      |.:.:|....|
Mouse   987 TPEQHQAFLYQLMQQQHHPPELQQLQLPG---------PTQIPINNLL------AGAQAPPLHTA 1036

  Fly  1389 TTSPLVVLSNQLPLNSVAAS 1408
            ||:|.:.:........|..|
Mouse  1037 TTNPFLTIHGDSTSQKVTVS 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	40/46 (87%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	80/114 (70%)
Mllt10	XP_006497436.2	PHD_AF10_AF17	24..71	CDD:277049	40/46 (87%)
Mllt10	XP_006497436.2	ePHD_AF10	78..206	CDD:277178	89/127 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2019
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004366
OrthoInspector	1	1.000	-	-		otm42615
orthoMCL	1	0.900	-	-		OOG6_105638
Panther	1	1.100	-	-	LDO	PTHR13793
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	1	1.000	-	-		X3088
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.080