DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and brpf1

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_012815976.1	Gene:	brpf1 / 100127652	XenbaseID:	XB-GENE-995817	Length:	1273	Species:	Xenopus tropicalis

Alignment Length:	1022	Identity:	222/1022 - (21%)
Similarity:	358/1022 - (35%)	Gaps:	258/1022 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            ||:|:|......|.:::||  .|.:||||.|||:..:|.|.|.||:| .|..:..|.|.|||::.
Frog   277 CCICNDGECQNSNVILFCD--MCNLAVHQECYGVPYIPEGQWLCRRC-LQSPSRAVDCALCPNKG 338

  Fly   126 GALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPI-ILSLIPQERYSKTCYICQEIGKPNRANVGA 189
            ||.|:||:..||||||||:||||.|.|...:||| .:..||..|:..|||||::.|.      ||
Frog   339 GAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRGS------GA 397

  Fly   190 CMQCNKSNCKQQFHVTCAQSLGL------LCEEAGNYLD-NVKYCGYCQHHYSKLKKGGNVKTIP 247
            |:||:|:||...|||||||..||      :.|...|... :|:...||..|    ...|:|..:|
Frog   398 CIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIH----TPPGSVCKLP 458

  Fly   248 PYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKITSSSGSAGGSSNVLNASSSAGISAGS-- 310
            .....:.:...|     |:|.|   ....:|..:.|..:.|......:..:.|...|.....|
Frog   459 ALSHSEGEEEDD-----EEEED---GKGWSSEKVKKAKAKSRIKMKKARKILAEKRAAAPVVSVP 515

  Fly   311 ----------------------------------SSGSGVS-----SSAKQRKSNASSKSSSSSS 336
                                              .|.:||.     .:..|.:.|...|:|||.|
Frog   516 CIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQRNCDQKASSSES 580

  Fly   337 SSSSSSTGGAPNPSSSSVHSGSASNMTGGGSVLPGSSNIGNISNSLNNNLPGGSSSTSSAGNVPG 401
            .::.|:.                  ::..|:|           ..:...:|       .:.:.||
Frog   581 ETTYSAC------------------LSAFGTV-----------QEMKWRIP-------ISDDTPG 609

  Fly   402 GSGGIISASSGGATQSTSSQSSTAPGTTKSSASSSSSSSNSYKEKHSKSLSKSTSSKDKDGKDSS 466
            ..|.|..::.....|:..:..:......|....|.....:..  :.::.|.:....::|..:::.
Frog   610 HLGTIAISNEEPGDQANKNDPTDKNWVLKEQLKSWQRLRHDL--ERARLLVELIRKREKLKRETI 672

  Fly   467 TNSANNNFTNSSASSTSSNSSSTREKSSSKLSKNKDSNQVPSATSSLSTTSSINTQPSSSTSTAT 531
            .       ....|............:.:.:|.:.||::.:.:....||..:.|...|........
Frog   673 K-------VQQMALEMQLTPFLILLRKTLELLQEKDTSNIFTEPVPLSEVTEIYEVPDYLEHVKK 730

  Fly   532 AGSGGT-GTHVSSSAASGLNSAPSTTNEHSNHAHTLSTNGTGAGSAAGKLQS-----VSNLSNSS 590
            .....| ..::.:......:......|...|:....:...|....||.:|:.     :......:
Frog   731 PMDFQTMKRNLEAFRYQNFDQFEEDFNLIVNNCIKYNAKDTIFYRAASRLREQGAALLRQARKQA 795

  Fly   591 SGFGSDLRSVSTSSSSTVNDSTGGFGSNSNSERENLSGAGSSASNMP--GTIAPGTGGVSSSAAT 653
            ...|.|..:..........:..|..|..::.||.:||   .|...:|  ..:......:....|:
Frog   796 EKIGIDFETGMHIHPVITGNEIGRHGRENDFERAHLS---DSRKQLPLEEQLKVQLARLDEVNAS 857

  Fly   654 NLSTNKGGSSSSTANSLTS---------TSTSSGSSSNSSSKKRKA-------------DSAKST 696
            ..|..:...:......:||         .|...|.|...||..|.|             |||...
Frog   858 KQSIGRARRAKMIRKEITSIRRKMVYQQESRRDGGSERHSSAGRGALPLHGPSEKDGQTDSAAEE 922

  Fly   697 SSISTSGSALEDNNSLISRYDIKDVQVALTPLTDFEKEIEKSSKRQRTELSPPTHQTS--ATAEV 759
            ||...:|..|..|.|..:.:::......|     |.|:..|::...:....||.::.:  ::.::
Frog   923 SSSQETGKGLGPNTSSTNAHEVGRRTSVL-----FSKKNPKTAGPPKRPGRPPKNRDNQLSSGQI 982

  Fly   760 NAPLASSTSASIAVTASATAASAPPATGTTTLGSSISGNAGSTSSGNSSGVSATGGAQ--SAVGS 822
            ::|:                  .||.                        :|.|||:|  ..|.|
Frog   983 SSPI------------------GPPQ------------------------LSVTGGSQRRKRVRS 1005

  Fly   823 GGYPKTESSKSSGTASAGSG---------SGSSSNTSSTK-----HGSNIKDISSSSNQQASTAS 873
               |:..||..|.:.|..|.         :|.||:|...|     :.::.....|||:.::||.|
Frog  1006 ---PRPTSSSDSDSDSEKSAEEPSLDLPTNGFSSSTQQVKKSFLVYRTDCNLPRSSSDSESSTTS 1067

  Fly   874 SSSAPSLYVSVPLSTANVPGINLP----------TSSTSSSTTSESHSASSR------SSGAQSQ 922
            ||||.|...|   :|.:..|...|          :|..:|.|.:||:|...|      ..|.:|:
Frog  1068 SSSAASDRTS---TTPSKQGRGKPSFSRDNFADYSSEDTSGTENESYSVGGRVGHGLVRKGLESR 1129

  Fly   923 HQQQLSN-----------------------ALVGPPMGGSAGAFHGG 946
            ....||.                       ||:..|.....|.||.|
Frog  1130 GAGWLSEDEDSPLEALDLVWAKCRGYPSYPALIIDPKMPREGVFHHG 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	20/45 (44%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	57/122 (47%)
brpf1	XP_012815976.1	SFP1	<21..53	CDD:227516
		COG5141	180..>558	CDD:227470	97/301 (32%)
		ePHD_BRPF1	331..451	CDD:277171	58/129 (45%)
		Bromodomain	685..788	CDD:383021	14/102 (14%)
		BR140_related	1142..1257	CDD:99900	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920