DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alh and brpf3b

DIOPT Version :9

Sequence 1:	NP_001262332.1	Gene:	Alh / 40850	FlyBaseID:	FBgn0261238	Length:	1717	Species:	Drosophila melanogaster
Sequence 2:	XP_005166793.1	Gene:	brpf3b / 100003354	ZFINID:	ZDB-GENE-081104-468	Length:	1222	Species:	Danio rerio

Alignment Length:	255	Identity:	89/255 - (34%)
Similarity:	125/255 - (49%)	Gaps:	46/255 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CCVCSDERGWPENPLVYCDGQNCTVAVHQACYGIVTVPTGPWYCRKCESQERTSRVRCELCPSRD 125
            ||||.|:.....|.:::||  .|.:||||.|||:..:|.|.|.||.| .|..:..|.|.|||:|.
Zfish   252 CCVCLDDECLNSNVILFCD--ICNLAVHQECYGVPYIPEGQWLCRCC-LQSPSRPVDCVLCPNRG 313

  Fly   126 GALKKTDNSGWAHVVCALYIPEVRFGNVTTMEPII-LSLIPQERYSKTCYICQEIGKPNRANVGA 189
            ||.|:|.:..|||||||::||||.|.|...:|||. :..||..|:..|||:|::.|      .||
Zfish   314 GAFKQTSDGRWAHVVCAIWIPEVCFANTVFLEPIEGVDNIPPARWKLTCYLCKQKG------CGA 372

  Fly   190 CMQCNKSNCKQQFHVTCAQSLGLLCEEAGNYLD------------NVKYCGYCQHHYSKL----- 237
            .:||:|:||...|||||||..||..:     :|            :||...:|:.|...:
Zfish   373 SIQCHKANCYTAFHVTCAQRAGLFMK-----IDPVRETTVNGTTFSVKKTAFCEAHSPAVNGSDD 432

  Fly   238 -KKGGNV------------KTIPPYKPIQHDTSSDSCSSPEKEIDSTMNSATTSATIIKI 284
             :.||.|            ...|..|..:.....|| ..|:|:......|..|:..::.:
Zfish   433 EETGGRVLGCRANRGRSAYMQTPELKKQKGSNKVDS-KQPQKKGKKEEVSKKTTTLLVTV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alh	NP_001262332.1	PHD_AF10_AF17	60..107	CDD:277049	21/45 (47%)
Alh	NP_001262332.1	ePHD_AF10_like	118..233	CDD:277142	53/127 (42%)
brpf3b	XP_005166793.1	EPL1	63..231	CDD:287484
		PHD_BRPF	249..302	CDD:277047	23/52 (44%)
		PHD_SF	306..423	CDD:304600	53/127 (42%)
		Kinesin-relat_1	535..>594	CDD:289481
		Bromo_brd1_like	608..705	CDD:99944
		BR140_related	1091..1206	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D566217at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1726
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950