DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mlp84B and MICAL2

DIOPT Version :9

Sequence 1:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001380866.1	Gene:	MICAL2 / 9645	HGNCID:	24693	Length:	1957	Species:	Homo sapiens

Alignment Length:	190	Identity:	42/190 - (22%)
Similarity:	62/190 - (32%)	Gaps:	60/190 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSFQPIEAPKCPRCGKSVYAA-----EERLAGGYVFHKNCFKCGMCNKSLDSTNCTEHERELYCK 61
            ||..|...|.......:|.:|     |::...|:.||.:                       :.:
Human   903 PSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPS-----------------------HLR 944

  Fly    62 TCHGR-KFGPKGYGFGTGAGTLSMDNGSQFLRENGDVPSVRNGARLEPRAIARAPEGEG------ 119
            |.|.: ..|....|.|..|..|              |....|..|  |:|.|.:|:.|.
Human   945 TVHPQLTVGKVSSGIGAAAEVL--------------VNLYMNDHR--PKAQATSPDLESMRKSFP 993

  Fly   120 --------CPRCGGYVYAAEQMLARGRSWHKECFKCGTCKKGLD-SILCCEAPDKNIYCK 170
                    |..|...||..|::.|.|..:|:|||:|..|...|. :....:..:...|||
Human   994 LNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCK 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788	7/57 (12%)
		LIM_CRP_like	120..173	CDD:188712	17/52 (33%)
		LIM_CRP_like	222..275	CDD:188712
		LIM_CRP_like	325..378	CDD:188712
		LIM_CRP_like	421..474	CDD:188712
MICAL2	NP_001380866.1	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	2..494
		UbiH	87..>226	CDD:357568
		CH	522..617	CDD:214479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..714
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24440334	660..681
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..942		10/61 (16%)
		LIM_Mical	1002..1056	CDD:188823	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1094
		PHA03247	<1087..1624	CDD:223021
		ProQ	1628..1718	CDD:198013
		DUF5401	<1773..>1944	CDD:375164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810