DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp84B and Lima1

DIOPT Version :9

Sequence 1:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001107017.1	Gene:	Lima1 / 65970	MGIID:	1920992	Length:	753	Species:	Mus musculus

Alignment Length:	209	Identity:	53/209 - (25%)
Similarity:	67/209 - (32%)	Gaps:	69/209 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FQPIEAPKCPRCGKSVYAAEERLAGGYVFHKNCFKCGMCNKSLD-STNCTEHERELYCKTCHGRK 67
            ||......|..|.|:||..|..||...|||.:||:|..||..|. .|..:.|.| :|||....:.
Mouse   380 FQAPAKESCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGR-IYCKPHFNQL 443

  Fly    68 FGPKG---YGFG-------------------------------------------TGAGTLSMDN 86
            |..||   .|||                                           .|....||:.
Mouse   444 FKSKGNYDEGFGHKQHKDLWASKSDNEETLGRPAQPPNAGESPHSPGVEDAPIAKVGVLAASMEA 508

  Fly    87 GSQFLRENGDVPSVRNGARLEPRAIARAPEGEGCPRCGGYVYAAEQMLARGR-SWHKECFKCGTC 150
            .:...||..|.|     |..:...||..|..|    .||...|.|:.:...: .|..|
Mouse   509 KASSQREREDKP-----AETKKLRIAWPPPAE----LGGSGSALEEGIKVSKPKWPPE------- 557

  Fly   151 KKGLDSILCCEAPD 164
                |.:...|||:
Mouse   558 ----DDVCKTEAPE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788	23/53 (43%)
		LIM_CRP_like	120..173	CDD:188712	10/46 (22%)
		LIM_CRP_like	222..275	CDD:188712
		LIM_CRP_like	325..378	CDD:188712
		LIM_CRP_like	421..474	CDD:188712
Lima1	NP_001107017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..186
		Required for interaction with NPC1L1. /evidence=ECO:0000269\|PubMed:29880681	164..166
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..379
		LIM_Eplin_alpha_beta	388..440	CDD:188869	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..493		0/25 (0%)
		Required for interaction with MYO5B. /evidence=ECO:0000269\|PubMed:29880681	491..511		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..669		21/83 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810