DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp84B and MICAL3

DIOPT Version :9

Sequence 1:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_056056.2	Gene:	MICAL3 / 57553	HGNCID:	24694	Length:	2002	Species:	Homo sapiens

Alignment Length:	147	Identity:	39/147 - (26%)
Similarity:	51/147 - (34%)	Gaps:	28/147 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ENGDVPSVRNGARLEPRAIARAPEGEG----CPRCGGYVYAAEQMLARGRSWHKECFKCGTCKKG 153
            ||....|:  |.|.:.......|:..|    |..|...||..|::.|.|:.:|:.||||..|...
Human   735 ENAPAQSI--GIRRQGSMKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATT 797

  Fly   154 LD-SILCCEAPDKNIYCKGCYAKKFGPKGYGYGQ-------------GGGALQSDCYAHDDGAPQ 204
            |. |....:..|...|||..|..:..    ||.|             ..|.||.......:|
Human   798 LRLSAYAYDIEDGKFYCKPHYCYRLS----GYAQRKRPAVAPLSGKEAKGPLQDGATTDANG--- 855

  Fly   205 IRAAIDVDKIQARPGEG 221
             ||.......:..||.|
Human   856 -RANAVASSTERTPGSG 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788
		LIM_CRP_like	120..173	CDD:188712	19/53 (36%)
		LIM_CRP_like	222..275	CDD:188712	39/147 (27%)
		LIM_CRP_like	325..378	CDD:188712
		LIM_CRP_like	421..474	CDD:188712
MICAL3	NP_056056.2	Monooxygenase domain. /evidence=ECO:0000250\|UniProtKB:Q8VDP3	2..494
		FAD_binding_3	87..>274	CDD:279792
		NAD_binding_8	91..>119	CDD:290186
		CH	524..619	CDD:278723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..706
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:24440334	663..684
		LIM_Mical	764..818	CDD:188823	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..883		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	907..1313
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1335..1776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1791..1821
		DUF3585	1850..1971	CDD:288945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810