DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mlp84B and mical2b

DIOPT Version :9

Sequence 1:	NP_001303418.1	Gene:	Mlp84B / 40849	FlyBaseID:	FBgn0014863	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_005174396.1	Gene:	mical2b / 569564	ZFINID:	ZDB-GENE-061207-15	Length:	1679	Species:	Danio rerio

Alignment Length:	359	Identity:	72/359 - (20%)
Similarity:	112/359 - (31%)	Gaps:	101/359 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HKNCFKCGMCNKSLDSTNCTEHERELYCKTCHGRKFGPKGYGFGTGAGTLSMDNGSQFLRENGDV 97
            ||.|.:....:...|..  ||..|.........|..|......|..|.||::      |.|....
Zfish   920 HKQCSEASETHLKADKH--TEIRRVERLDPSKQRTVGKVSSAIGVKAATLAI------LYETDHR 976

  Fly    98 PSVRNGARLEPRAIARAPE----------------GEGCPRCGGYVYAAEQMLARGRSWHKECFK 146
            |:  |...|......|..|                .:.|..|...||..|::.|.|..:|:|||:
Zfish   977 PN--NPITLSLTEARRCAESGLVSVRKEFSASLGGSDTCVFCQKRVYIMERLSAEGFFFHRECFR 1039

  Fly   147 CGTC----KKGLDSILCCEAPDKNIYCKGCYAKKFGPKGYGYG--QGGGALQSDC----YAHDDG 201
            |..|    :.|..:.   ::.....|||..::::.....:..|  |.||...|..    :...||
Zfish  1040 CHICGCSLRLGAHTF---DSQQGTFYCKMHFSQRKTSTRHRRGEIQDGGIRSSSITISNHTSTDG 1101

  Fly   202 A--------------------PQIRAAIDVDKI-----QARPGEGCPRC-GGVVYAAEQKLSKGR 240
            .                    |..:..|.|.::     :|.|.:..|.| ...:...::..:||.
Zfish  1102 TRGQPSGGEFDSSTQQDLQTLPDSKEIISVSEVKDSSKKADPADSAPACPDSPLQKVKRSTAKGE 1166

  Fly   241 EWHKKCFNCKDCHKTLDSINASDGPDRDVYCRTCYGKKWGPHGYGFACGSGFLQTDGLTE----- 300
            ..:|.....|....||..:               ..||       |..|....:|:.|.|
Zfish  1167 ITNKNILWKKKIRSTLPLV---------------LMKK-------FHRGKPEDKTEVLAEEDGNS 1209

  Fly   301 ------DQISANRPFYNPDTTS--IKARDGEGCP 326
                  :.:|:.:| .||.|.|  :..:|....|
Zfish  1210 DFEEIHESLSSKKP-SNPSTDSNCLPTKDNSSTP 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mlp84B	NP_001303418.1	LIM1_MLP84B_like	11..64	CDD:188788	7/30 (23%)
		LIM_CRP_like	120..173	CDD:188712	17/56 (30%)
		LIM_CRP_like	222..275	CDD:188712	8/53 (15%)
		LIM_CRP_like	325..378	CDD:188712	1/2 (50%)
		LIM_CRP_like	421..474	CDD:188712
mical2b	XP_005174396.1	FAD_binding_3	86..>274	CDD:332373
		CH	522..623	CDD:306753
		LIM_Mical	1013..1067	CDD:188823	17/56 (30%)
		Atrophin-1	1080..>1344	CDD:331285	34/186 (18%)
		YesN	<1308..1371	CDD:330857
		DUF3585	1530..1665	CDD:314926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810