DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub84B and Tubd1

DIOPT Version :9

Sequence 1:	NP_476772.1	Gene:	alphaTub84B / 40848	FlyBaseID:	FBgn0003884	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001185974.1	Gene:	Tubd1 / 56427	MGIID:	1891826	Length:	486	Species:	Mus musculus

Alignment Length:	555	Identity:	114/555 - (20%)
Similarity:	198/555 - (35%)	Gaps:	196/555 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ISIHVGQAGVQIG----------------------NACWELYCLEHGIQPDGQMPSDKTVGGGDD 47
            :::.:||.|.|||                      |..::..|.|.
Mouse     4 VTVQLGQCGNQIGFEVFDALFRDSHCSQGLCSKRDNEAYQASCRER------------------- 49

  Fly    48 SFNTFFSETGAGKHVPRAVFVDLEPTVVDE-----VRTGTYRQLFHPEQLITGKEDAANNYARGH 107
                ||.|...|..|.|||.||:||.|:::     .::|.:....|..  ...|:.:.||:|.|:
Mouse    50 ----FFREEENGVPVARAVLVDMEPKVINQTLSKAAQSGRWNYGQHTS--FCQKQGSGNNWAYGY 108

  Fly   108 YTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIY 172
            ...|.:..:.:::.|:...::|..|.||.|..|..||||||..:.:.::|...|....|:...|:
Mouse   109 SVHGPKHEESIMNLIQTEVEKCDSLSGFFIIMSMAGGTGSGLGAFVTQKLQDQYSSSLKMNQIIW 173

  Fly   173 PAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSS 237
            |. .....:|:.||||||.......||...:.:|:|::.||.:.::|::.::.:||:::...:.|
Mouse   174 PY-GTGEVIVQNYNSILTLSHLYRSSDALLIHENDAVHKICAKRMNIKQISFRDLNQVLAHQLGS 237

  Fly   238 I-------TASLRFD------------------------GALNV-------DLTEFQTNLVPYP- 263
            :       .:|..:.                        .|.|:       ||.|   :|||:|
Mouse   238 VFQPTYSEDSSFHYRRNPLDSGTVGPQACLMPRIFVWSLSATNLSFYPQTGDLME---HLVPHPE 299

  Fly   264 -----------------------------------------------RIHFPLVTYAPV--ISAE 279
                                                           ::..||....|:  .||.
Mouse   300 FKMLGVRNIPQMSAASLAYSAFTWAGLLKHLRQMLISSAKMEEGINWQVRPPLTGLPPIGKASAH 364

  Fly   280 KAYHEQLSVA--------EITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIK 336
            |.:|...|:|        |:.:|..|...     ||         .||...:.|.|   |.:..|
Mouse   365 KEHHFNTSLANLVVLRGREVHSADVEGFK-----DP---------ALYTSWLEPVD---AFSVWK 412

  Fly   337 TKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAK 401
            |:|...                           |.:::..::||:..:.:....:..|...|::.
Mouse   413 TQRAFD---------------------------KYEKSAALVSNSQLLVKPLDMIVGKAWNMFSS 450

  Fly   402 RAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVG 436
            :||:|.|...||||.:|.::...|..:...|..:|
Mouse   451 KAFIHQYTKFGMEEEDFLDSFALLEQVVASYGSLG 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	114/555 (21%)
Tubd1	NP_001185974.1	delta_zeta_tubulin-like	2..483	CDD:276958	113/551 (21%)
Tubd1	NP_001185974.1	Tubulin	2..213	CDD:278518	59/234 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900