DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaTub84B and alphaTub67C

DIOPT Version :9

Sequence 1:	NP_476772.1	Gene:	alphaTub84B / 40848	FlyBaseID:	FBgn0003884	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_524009.2	Gene:	alphaTub67C / 39130	FlyBaseID:	FBgn0087040	Length:	462	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	317/460 - (68%)
Similarity:	383/460 - (83%)	Gaps:	14/460 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVG--------GGDDSFN---TFFS 54
            |||.:||.:||.|:||||||||||.|||||..||.:.:.:.:.        |.|.|.|   |||:
  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65

  Fly    55 ETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVL 119
            |||.||.|||::||||||||:|:||.|..|:|:||||||:||||||||||||.|:||||::|.|.
  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130

  Fly   120 DRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEP 184
            .|::|:|:||..|||||||||.||||||||||||:||||.||.||.||:||:||:|:||||||||
  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195

  Fly   185 YNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALN 249
            ||::||||:|::||||.||||||||||||..:|.::||.|.||||||.|||||.||||||.|::|
  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260

  Fly   250 VDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMA 314
            |||.||||||||:||||||||.|||::|||::.|||.::..:||||||.:|.|||||||.||:||
  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITTLTNACFESSNMMVKCDPRAGKFMA 325

  Fly   315 CCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLS 379
            |||||||||||||||||::.||:||.||||||||||||:||||:.|..||.|||||..||.||||
  Fly   326 CCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLS 390

  Fly   380 NTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEG 444
            |||||:.|::.|.:|||||:.||||||||||||||||||:||||::|.||:|:||||:|:.:
  Fly   391 NTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAE--- 452

  Fly   445 EGAEE 449
            ||.:|
  Fly   453 EGGDE 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	313/448 (70%)
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	309/443 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S25
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D275336at33208
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100108
Panther	1	1.100	-	-	P	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.700